UHGV

Unified Human Gut Virome catalog

A comprehensive resource of human gut viruses with thoroughly annotated genes, protein structures, and novel hierarchical classification system for genomes.

873,994 Genomes 168,536 vOTUs 1,063,184 Protein clusters 56,832 Protein structures

Explore UHGV

Browse
Genomes

Virus genomes isolated from human gut microbiome samples.
Browse
vOTUs

Clusters of highly similar genomes that represent operational taxonomic units.
Browse
Protein clusters

Clusters of viral proteins featuring predicted structures and functional annotations.
Data
Download data

Retrieve genomes, protein sequences, structures, annotations, and metadata.
Tools
Genome search

Compare your viral genomes against the UHGV genome collection.
Tools
Protein search

Query your proteins against the UHGV collection of viral proteins.
Tools
Structure search

Perform structure searches against the UHGV's predicted protein structures.
Data
REST API

Programmatic access to UHGV datasets allowing automated querying.

Cite UHGV

bioRxiv preprint A genomic atlas of the human gut virome elucidates genetic factors shaping host interactions Camargo, A. P., Baltoumas, F. A., Ndela, E. O., Fiamenghi, M. B., Merrill, B. D., Carter, M. M., Pinto, Y., Chakraborty, M., Andreeva, A., Ghiotto, G., Shaw, J., Proal, A. D., Sonnenburg, J. L., Bhatt, A. S., Roux, S., Pavlopoulos, G. A., Nayfach, S., & Kyrpides, N. C. bioRxiv (2025) — doi:10.1101/2025.11.01.686033