| UHGV-0025247_1 | PHROG | phrog_7168 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_1 | UniRef90 | UniRef90_A0A843GGY5 | GIY-YIG nuclease family protein | NA |
| UHGV-0025247_1 | eggNOG-mapper | 742735.HMPREF9467_00770 | GIY-YIG type nucleases (URI domain) | NA |
| UHGV-0025247_1 | PADLOC | HEase_00030 | homing endonuclease | RM |
| UHGV-0025247_1 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-0025247_1 | NCBIFam | TIGR01453.1 | group I intron endonuclease | NA |
| UHGV-0025247_1 | Structural annotation | PF19835, PF02796, TIGR01453 | NA | NA |
| UHGV-0025247_5 | KOfam | K01938 | fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] | NA |
| UHGV-0025247_5 | UniRef90 | UniRef90_R6RVJ9 | Formate--tetrahydrofolate ligase | NA |
| UHGV-0025247_5 | eggNOG-mapper | 1209989.TepiRe1_0600 | PFAM formate-tetrahydrofolate ligase FTHFS | NA |
| UHGV-0025247_5 | Pfam | PF01268 | Formate--tetrahydrofolate ligase | FTHFS |
| UHGV-0025247_5 | NCBIFam | NF010030.0 | formate--tetrahydrofolate ligase | NA |
| UHGV-0025247_5 | COG | COG2759 | Formyltetrahydrofolate synthetase | NA |
| UHGV-0025247_5 | HAMAP | MF_01543 | Formate--tetrahydrofolate ligase [fhs] | NA |
| UHGV-0025247_7 | PHROG | phrog_850 | RNA-binding protein | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_7 | UniRef90 | UniRef90_A0A843FJC6 | NA | NA |
| UHGV-0025247_7 | eggNOG-mapper | 1408312.JNJS01000007_gene1149 | NA | NA |
| UHGV-0025247_7 | Pfam | PF11443 | NA | DUF2828 |
| UHGV-0025247_7 | COG | COG2304 | Secreted protein containing bacterial Ig-like domain and vWFA domain | NA |
| UHGV-0025247_7 | Structural annotation | PF11443, MF_01340, COG2304 | NA | NA |
| UHGV-0025247_15 | PHROG | phrog_35541 | NA | unknown function |
| UHGV-0025247_15 | UniRef90 | UniRef90_A0A3D6B2G4 | Mtd_N domain-containing protein | NA |
| UHGV-0025247_15 | eggNOG-mapper | 753085.F4YCS2_9CAUD | NA | NA |
| UHGV-0025247_15 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-0025247_15 | Structural annotation | PF18454 | NA | NA |
| UHGV-0025247_16 | PHROG | phrog_38190 | NA | unknown function |
| UHGV-0025247_16 | eggNOG-mapper | 762211.BSTEL_0610 | NA | NA |
| UHGV-0025247_17 | Structural annotation | PF20010 | NA | NA |
| UHGV-0025247_18 | KOfam | K07313 | pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16] | NA |
| UHGV-0025247_18 | PHROG | phrog_246 | NinI-like serine-threonine phosphatase | other |
| UHGV-0025247_18 | UniRef90 | UniRef90_A0A143XVH8 | Serine/threonine-protein phosphatase 2 | NA |
| UHGV-0025247_18 | eggNOG-mapper | 1232449.BAHV02000002_gene245 | Calcineurin-like phosphoesterase superfamily domain | NA |
| UHGV-0025247_18 | Pfam | PF00149 | Calcineurin-like phosphoesterase | Metallophos |
| UHGV-0025247_18 | COG | COG0639 | Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family | NA |
| UHGV-0025247_18 | Structural annotation | PF14582, MF_01443, NF007425, COG0622 | NA | NA |
| UHGV-0025247_19 | eggNOG-mapper | 546271.Selsp_1706 | DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor | NA |
| UHGV-0025247_19 | COG | COG4465 | GTP-sensing pleiotropic transcriptional regulator CodY | NA |
| UHGV-0025247_20 | KOfam | K03086 | rpoD; RNA polymerase primary sigma factor | NA |
| UHGV-0025247_20 | PHROG | phrog_351 | RNA polymerase sigma factor | transcription regulation |
| UHGV-0025247_20 | UniRef90 | UniRef90_A0A6L5Y1Y2 | RNA polymerase sigma factor SigA | NA |
| UHGV-0025247_20 | eggNOG-mapper | 309803.CTN_1042 | Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth | NA |
| UHGV-0025247_20 | PADLOC | MzaA_00001 | NA | mzaABCDE |
| UHGV-0025247_20 | Pfam | PF00140 | Sigma-70 factor, region 1.2 | Sigma70_r1_2 |
| UHGV-0025247_20 | Pfam | PF04542 | Sigma-70 region 2 | Sigma70_r2 |
| UHGV-0025247_20 | Pfam | PF04539 | Sigma-70 region 3 | Sigma70_r3 |
| UHGV-0025247_20 | Pfam | PF04545 | Sigma-70, region 4 | Sigma70_r4 |
| UHGV-0025247_20 | NCBIFam | TIGR02937.1 | sigma-70 family RNA polymerase sigma factor | NA |
| UHGV-0025247_20 | COG | COG0568 | DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) | NA |
| UHGV-0025247_20 | Structural annotation | PF04542, PF04539, MF_00959, NF005920, COG0568 | NA | NA |
| UHGV-0025247_22 | KOfam | K07074 | NA | NA |
| UHGV-0025247_22 | PHROG | phrog_388 | nucleotidyltransferase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_22 | UniRef90 | UniRef90_A0A843FSU3 | Nucleotidyltransferase domain-containing protein | NA |
| UHGV-0025247_22 | eggNOG-mapper | 498761.HM1_0723 | Predicted nucleotidyltransferase | NA |
| UHGV-0025247_22 | Structural annotation | PF10127, NF000079, COG3541 | NA | NA |
| UHGV-0025247_23 | PHROG | phrog_968 | RNA ligase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_23 | UniRef90 | UniRef90_A0A843GTM3 | RNA_ligase domain-containing protein | NA |
| UHGV-0025247_23 | eggNOG-mapper | 5762.XP_002669268.1 | RNA ligase | NA |
| UHGV-0025247_23 | Pfam | PF21189 | PHA02142 OB-fold domain | PHA02142 |
| UHGV-0025247_23 | Pfam | PF09414 | RNA ligase | RNA_ligase |
| UHGV-0025247_23 | Structural annotation | PF21189, PF09511, MF_04150, TIGR02306, COG1423, COG0073 | NA | NA |
| UHGV-0025247_24 | PHROG | phrog_547 | phosphoesterase | other |
| UHGV-0025247_24 | UniRef90 | UniRef90_A0A1I0M725 | Calcineurin-like phosphoesterase superfamily protein | NA |
| UHGV-0025247_24 | eggNOG-mapper | 1392491.JIAE01000001_gene1129 | Calcineurin-like phosphoesterase | NA |
| UHGV-0025247_24 | Pfam | PF00149 | Calcineurin-like phosphoesterase | Metallophos |
| UHGV-0025247_24 | COG | COG4186 | NA | NA |
| UHGV-0025247_24 | Structural annotation | NF006988, COG4186 | NA | NA |
| UHGV-0025247_25 | Structural annotation | PF21662 | NA | NA |
| UHGV-0025247_26 | KOfam | K07175 | phoH2; PhoH-like ATPase | NA |
| UHGV-0025247_26 | PHROG | phrog_2765 | PhoH-like phosphate starvation-inducible | other |
| UHGV-0025247_26 | UniRef90 | UniRef90_A0A843GX46 | PhoH family protein | NA |
| UHGV-0025247_26 | eggNOG-mapper | 1123252.ATZF01000010_gene420 | PIN domain | NA |
| UHGV-0025247_26 | Pfam | PF13638 | PIN domain | PIN_4 |
| UHGV-0025247_26 | Pfam | PF02562 | PhoH-like protein | PhoH |
| UHGV-0025247_26 | COG | COG1875 | Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains | NA |
| UHGV-0025247_26 | Structural annotation | PF02562, PF13638, PF09142, MF_00265, NF007827, NF009148, COG1875 | NA | NA |
| UHGV-0025247_27 | PHROG | phrog_13712 | holin | lysis |
| UHGV-0025247_27 | Structural annotation | PF09682, TIGR01673 | NA | NA |
| UHGV-0025247_28 | KOfam | K03469 | rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] | NA |
| UHGV-0025247_28 | PHROG | phrog_531 | Rnase H | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_28 | UniRef90 | UniRef90_A0A354G2K2 | Ribonuclease H | NA |
| UHGV-0025247_28 | eggNOG-mapper | 377629.TERTU_2111 | RNase H | NA |
| UHGV-0025247_28 | Pfam | PF00075 | RNase H | RNase_H |
| UHGV-0025247_28 | COG | COG0328 | Ribonuclease HI | NA |
| UHGV-0025247_28 | Structural annotation | PF00075, MF_00042, NF001236, COG0328 | NA | NA |
| UHGV-0025247_30 | KOfam | K02470 | gyrB; DNA gyrase subunit B [EC:5.6.2.2] | NA |
| UHGV-0025247_30 | PHROG | phrog_543 | DNA topoisomerase II large subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_30 | UniRef90 | UniRef90_A0A3B9Z7X0 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-0025247_30 | eggNOG-mapper | 390874.Tpet_0094 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-0025247_30 | Pfam | PF00204 | DNA gyrase B | DNA_gyraseB |
| UHGV-0025247_30 | Pfam | PF01751 | Toprim domain | Toprim |
| UHGV-0025247_30 | COG | COG0187 | DNA gyrase/topoisomerase IV, subunit B | NA |
| UHGV-0025247_30 | Structural annotation | PF00204, MF_01898, NF004189, COG0187 | NA | NA |
| UHGV-0025247_31 | PHROG | phrog_5123 | homing endonuclease with GIY-YIG motif | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_31 | UniRef90 | UniRef90_A0A4V6KED1 | GIY-YIG domain-containing protein | NA |
| UHGV-0025247_31 | PADLOC | HEase_00030 | homing endonuclease | RM |
| UHGV-0025247_31 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-0025247_31 | NCBIFam | TIGR01453.1 | group I intron endonuclease | NA |
| UHGV-0025247_31 | COG | COG3860 | NA | NA |
| UHGV-0025247_31 | Structural annotation | PF19835, PF02796, TIGR01453 | NA | NA |
| UHGV-0025247_32 | KOfam | K02470 | gyrB; DNA gyrase subunit B [EC:5.6.2.2] | NA |
| UHGV-0025247_32 | PHROG | phrog_543 | DNA topoisomerase II large subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_32 | UniRef90 | UniRef90_A0A843FJ11 | Toprim domain-containing protein | NA |
| UHGV-0025247_32 | eggNOG-mapper | 1408436.JHXY01000008_gene2394 | DNA gyrase | NA |
| UHGV-0025247_32 | Pfam | PF00986 | DNA gyrase B subunit, carboxyl terminus | DNA_gyraseB_C |
| UHGV-0025247_32 | COG | COG0187 | DNA gyrase/topoisomerase IV, subunit B | NA |
| UHGV-0025247_32 | Structural annotation | PF00986 | NA | NA |
| UHGV-0025247_34 | KOfam | K02469 | gyrA; DNA gyrase subunit A [EC:5.6.2.2] | NA |
| UHGV-0025247_34 | PHROG | phrog_551 | DNA topoisomerase II | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_34 | UniRef90 | UniRef90_A0A832SNJ2 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-0025247_34 | eggNOG-mapper | 33035.JPJF01000072_gene4351 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-0025247_34 | Pfam | PF00521 | DNA gyrase/topoisomerase IV, subunit A | DNA_topoisoIV |
| UHGV-0025247_34 | Pfam | PF03989 | DNA gyrase C-terminal domain, beta-propeller | DNA_gyraseA_C |
| UHGV-0025247_34 | COG | COG0188 | DNA gyrase/topoisomerase IV, subunit A | NA |
| UHGV-0025247_34 | Structural annotation | PF00521, PF03989, MF_01897, NF004043, COG0188 | NA | NA |
| UHGV-0025247_36 | KOfam | K01972 | E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] | NA |
| UHGV-0025247_36 | PHROG | phrog_3869 | NAD-dependent DNA ligase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_36 | UniRef90 | UniRef90_A0A843FQD5 | DNA ligase | NA |
| UHGV-0025247_36 | eggNOG-mapper | 411470.RUMGNA_00017 | DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA | NA |
| UHGV-0025247_36 | Pfam | PF01653 | NAD-dependent DNA ligase adenylation domain | DNA_ligase_aden |
| UHGV-0025247_36 | Pfam | PF03120 | NAD-dependent DNA ligase OB-fold domain | DNA_ligase_OB |
| UHGV-0025247_36 | Pfam | PF00533 | BRCA1 C Terminus (BRCT) domain | BRCT |
| UHGV-0025247_36 | NCBIFam | TIGR00575.1 | NAD-dependent DNA ligase LigA | NA |
| UHGV-0025247_36 | COG | COG0272 | NAD-dependent DNA ligase | NA |
| UHGV-0025247_36 | HAMAP | MF_01588 | DNA ligase [ligA] | NA |
| UHGV-0025247_36 | Structural annotation | PF01653, PF03120, PF00533, MF_01588, NF005932, COG0272 | NA | NA |
| UHGV-0025247_38 | Structural annotation | PF04182, MF_01909, NF040939, COG1675 | NA | NA |
| UHGV-0025247_39 | PHROG | phrog_314 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_39 | UniRef90 | UniRef90_A0A843GN52 | GIY-YIG nuclease family protein | NA |
| UHGV-0025247_39 | eggNOG-mapper | 1427984.X271_00109 | NA | NA |
| UHGV-0025247_39 | PADLOC | HEase_00030 | homing endonuclease | RM |
| UHGV-0025247_39 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-0025247_39 | NCBIFam | TIGR01453.1 | group I intron endonuclease | NA |
| UHGV-0025247_39 | Structural annotation | PF19835, TIGR01453 | NA | NA |
| UHGV-0025247_40 | KOfam | K01358 | clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] | NA |
| UHGV-0025247_40 | PHROG | phrog_94 | head maturation protease | head and packaging |
| UHGV-0025247_40 | UniRef90 | UniRef90_A0A843GPG7 | ATP-dependent Clp protease proteolytic subunit | NA |
| UHGV-0025247_40 | eggNOG-mapper | 537007.BLAHAN_05297 | Clp protease | NA |
| UHGV-0025247_40 | Pfam | PF00574 | Clp protease | CLP_protease |
| UHGV-0025247_40 | COG | COG0740 | ATP-dependent protease ClpP, protease subunit | NA |
| UHGV-0025247_41 | KOfam | K03465 | thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] | NA |
| UHGV-0025247_41 | PHROG | phrog_85 | thymidylate synthase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_41 | UniRef90 | UniRef90_A0A348XSF2 | Thymidylate synthase | NA |
| UHGV-0025247_41 | eggNOG-mapper | 1282887.AUJG01000001_gene1906 | thymidylate synthase (FAD) activity | NA |
| UHGV-0025247_41 | Pfam | PF02511 | Thymidylate synthase complementing protein | Thy1 |
| UHGV-0025247_41 | COG | COG1351 | Thymidylate synthase ThyX, FAD-dependent family | NA |
| UHGV-0025247_41 | Structural annotation | PF02511, MF_01408, TIGR02170, COG1351 | NA | NA |
| UHGV-0025247_42 | UniRef90 | UniRef90_A0A345BPT4 | LexA repressor | NA |
| UHGV-0025247_42 | Pfam | PF13463 | Winged helix DNA-binding domain | HTH_27 |
| UHGV-0025247_42 | Structural annotation | PF03444, MF_00732, TIGR02337, COG1321 | NA | NA |
| UHGV-0025247_43 | PHROG | phrog_2367 | NA | unknown function |
| UHGV-0025247_43 | Structural annotation | PF00436, PF19649, MF_00984, NF004476, COG2965 | NA | NA |
| UHGV-0025247_44 | PHROG | phrog_124 | Sak4-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_44 | UniRef90 | UniRef90_A0A832SVD6 | ATP-binding protein | NA |
| UHGV-0025247_44 | eggNOG-mapper | 1541960.KQ78_01919 | Belongs to the helicase family. UvrD subfamily | NA |
| UHGV-0025247_44 | Pfam | PF13479 | AAA domain | AAA_24 |
| UHGV-0025247_44 | COG | COG2887 | RecB family exonuclease | NA |
| UHGV-0025247_44 | Structural annotation | PF13479, MF_00350, TIGR01618, COG0468 | NA | NA |
| UHGV-0025247_45 | PHROG | phrog_4680 | NA | unknown function |
| UHGV-0025247_45 | UniRef90 | UniRef90_A0A3S4N9I4 | NA | NA |
| UHGV-0025247_45 | eggNOG-mapper | 1280.SAXN108_2226 | NA | NA |
| UHGV-0025247_46 | KOfam | K02314 | dnaB; replicative DNA helicase [EC:5.6.2.3] | NA |
| UHGV-0025247_46 | PHROG | phrog_19 | DnaB-like replicative helicase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_46 | UniRef90 | UniRef90_A0A843FNV1 | DNA helicase | NA |
| UHGV-0025247_46 | eggNOG-mapper | 224308.BSU20370 | DnaB-like helicase C terminal domain | NA |
| UHGV-0025247_46 | Pfam | PF00772 | DnaB-like helicase N terminal domain | DnaB |
| UHGV-0025247_46 | Pfam | PF03796 | DnaB-like helicase C terminal domain | DnaB_C |
| UHGV-0025247_46 | COG | COG0305 | Replicative DNA helicase | NA |
| UHGV-0025247_46 | Structural annotation | PF03796, PF00772, MF_04155, TIGR00665, COG0305 | NA | NA |
| UHGV-0025247_47 | KOfam | K02316 | dnaG; DNA primase [EC:2.7.7.101] | NA |
| UHGV-0025247_47 | PHROG | phrog_47 | DNA primase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_47 | UniRef90 | UniRef90_A0A345BPU0 | DNA primase | NA |
| UHGV-0025247_47 | eggNOG-mapper | 176279.SERP1591 | DNA primase activity | NA |
| UHGV-0025247_47 | COG | COG0358 | DNA primase (bacterial type) | NA |
| UHGV-0025247_47 | Structural annotation | PF01807, PF19898, MF_00974, NF006382, COG0358 | NA | NA |
| UHGV-0025247_48 | PHROG | phrog_799 | DNA methyltransferase | other |
| UHGV-0025247_48 | UniRef90 | UniRef90_A0A3R6PT83 | tRNA (Adenine-N(6)-)-methyltransferase | NA |
| UHGV-0025247_48 | eggNOG-mapper | 641112.ACOK01000119_gene1514 | NA | NA |
| UHGV-0025247_48 | Structural annotation | PF13651, MF_00607, NF000077, COG0286 | NA | NA |
| UHGV-0025247_49 | KOfam | K07462 | recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] | NA |
| UHGV-0025247_49 | PHROG | phrog_2484 | RecJ-like ssDNA exonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_49 | UniRef90 | UniRef90_A0A843GQK3 | DHH family phosphoesterase | NA |
| UHGV-0025247_49 | eggNOG-mapper | 224308.BSU20350 | Single-stranded-DNA-specific exonuclease RecJ | NA |
| UHGV-0025247_49 | Pfam | PF01368 | DHH family | DHH |
| UHGV-0025247_49 | Pfam | PF17768 | RecJ OB domain | RecJ_OB |
| UHGV-0025247_49 | COG | COG0608 | ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation | NA |
| UHGV-0025247_49 | Structural annotation | PF17768, PF02272, MF_00207, TIGR00644, COG0608 | NA | NA |
| UHGV-0025247_50 | KOfam | K03581 | recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] | NA |
| UHGV-0025247_50 | PHROG | phrog_325 | Dda-like helicase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_50 | UniRef90 | UniRef90_A0A843GQ82 | AAA family ATPase | NA |
| UHGV-0025247_50 | eggNOG-mapper | 1121085.AUCI01000012_gene2815 | A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD | NA |
| UHGV-0025247_50 | PADLOC | cluster10 | RecD_0_IVD | CRISPR-CAS |
| UHGV-0025247_50 | Pfam | PF13604 | AAA domain | AAA_30 |
| UHGV-0025247_50 | Pfam | PF13538 | UvrD-like helicase C-terminal domain | UvrD_C_2 |
| UHGV-0025247_50 | COG | COG0507 | ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) | NA |
| UHGV-0025247_50 | Structural annotation | PF13604, MF_01488, TIGR01448, COG0507 | NA | NA |
| UHGV-0025247_52 | PHROG | phrog_314 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_52 | UniRef90 | UniRef90_S1NAK7 | GIY-YIG domain-containing protein | NA |
| UHGV-0025247_52 | eggNOG-mapper | 1139219.I569_01385 | NUMOD3 motif (2 copies) | NA |
| UHGV-0025247_52 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-0025247_52 | Structural annotation | PF19835, TIGR01453 | NA | NA |
| UHGV-0025247_53 | KOfam | K00571 | E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] | NA |
| UHGV-0025247_53 | PHROG | phrog_67 | DNA methyltransferase | other |
| UHGV-0025247_53 | UniRef90 | UniRef90_A0A416DTS0 | Methyltransferase | NA |
| UHGV-0025247_53 | eggNOG-mapper | 553220.CAMGR0001_2118 | Belongs to the N(4) N(6)-methyltransferase family | NA |
| UHGV-0025247_53 | PADLOC | MTase_II_00157 | Type II methyltransferase | RM |
| UHGV-0025247_53 | Pfam | PF01555 | DNA methylase | N6_N4_Mtase |
| UHGV-0025247_53 | COG | COG2189 | Adenine specific DNA methylase Mod | NA |
| UHGV-0025247_53 | Structural annotation | PF01555, MF_01872, NF008572, COG0863 | NA | NA |
| UHGV-0025247_54 | KOfam | K02337 | dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] | NA |
| UHGV-0025247_54 | PHROG | phrog_405 | DNA polymerase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_54 | UniRef90 | UniRef90_A0A843GL03 | DNA-directed DNA polymerase | NA |
| UHGV-0025247_54 | eggNOG-mapper | 224308.BSU20340 | DNA polymerase | NA |
| UHGV-0025247_54 | Pfam | PF02811 | PHP domain | PHP |
| UHGV-0025247_54 | Pfam | PF07733 | Bacterial DNA polymerase III alpha NTPase domain | DNA_pol3_alpha |
| UHGV-0025247_54 | Pfam | PF17657 | Bacterial DNA polymerase III alpha subunit finger domain | DNA_pol3_finger |
| UHGV-0025247_54 | Pfam | PF14579 | Helix-hairpin-helix motif | HHH_6 |
| UHGV-0025247_54 | COG | COG0587 | DNA polymerase III, alpha subunit | NA |
| UHGV-0025247_54 | Structural annotation | PF07733, PF02811, PF17657, PF14579, MF_01902, NF005617, COG0587 | NA | NA |
| UHGV-0025247_55 | KOfam | K00942 | gmk, GUK1; guanylate kinase [EC:2.7.4.8] | NA |
| UHGV-0025247_55 | PHROG | phrog_1815 | guanylate kinase | other |
| UHGV-0025247_55 | UniRef90 | UniRef90_A0A1G5EWX3 | Guanylate kinase | NA |
| UHGV-0025247_55 | eggNOG-mapper | 411460.RUMTOR_01402 | NA | NA |
| UHGV-0025247_55 | Pfam | PF00625 | Guanylate kinase | Guanylate_kin |
| UHGV-0025247_55 | COG | COG0194 | Guanylate kinase | NA |
| UHGV-0025247_55 | Structural annotation | PF00625, MF_00328, NF011324, COG0194 | NA | NA |
| UHGV-0025247_56 | KOfam | K21636 | nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] | NA |
| UHGV-0025247_56 | PHROG | phrog_487 | NrdD-like anaerobic ribonucleotide reductase large subunit | moron, auxiliary metabolic gene and host takeover |
| UHGV-0025247_56 | UniRef90 | UniRef90_A0A3R6SNB8 | Anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-0025247_56 | eggNOG-mapper | 1304866.K413DRAFT_4593 | Ribonucleoside-triphosphate reductase | NA |
| UHGV-0025247_56 | Pfam | PF03477 | ATP cone domain | ATP-cone |
| UHGV-0025247_56 | Pfam | PF13597 | Anaerobic ribonucleoside-triphosphate reductase | NRDD |
| UHGV-0025247_56 | NCBIFam | TIGR02487.1 | anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-0025247_56 | COG | COG1328 | Anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-0025247_56 | Structural annotation | PF13597, PF03477, MF_00440, NF005497, COG1328 | NA | NA |
| UHGV-0025247_57 | KOfam | K04068 | nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] | NA |
| UHGV-0025247_57 | PHROG | phrog_626 | anaerobic ribonucleotide reductase small subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_57 | UniRef90 | UniRef90_A0A843FG79 | Anaerobic ribonucleoside-triphosphate reductase activating protein | NA |
| UHGV-0025247_57 | eggNOG-mapper | 1391646.AVSU01000022_gene2701 | Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine | NA |
| UHGV-0025247_57 | Pfam | PF13353 | 4Fe-4S single cluster domain | Fer4_12 |
| UHGV-0025247_57 | NCBIFam | TIGR02491.1 | anaerobic ribonucleoside-triphosphate reductase activating protein | NA |
| UHGV-0025247_57 | COG | COG0602 | Organic radical activating enzyme NrdG/QueE | NA |
| UHGV-0025247_57 | Structural annotation | PF13353, MF_00917, TIGR02491, COG0602 | NA | NA |
| UHGV-0025247_58 | UniRef90 | UniRef90_A0A7U9TI84 | Transporter | NA |
| UHGV-0025247_58 | eggNOG-mapper | 1105031.HMPREF1141_3499 | Formate/nitrite transporter | NA |
| UHGV-0025247_58 | Pfam | PF01226 | Formate/nitrite transporter | Form_Nir_trans |
| UHGV-0025247_58 | COG | COG2116 | Formate/nitrite transporter FocA, FNT family | NA |
| UHGV-0025247_60 | Structural annotation | PF10750, MF_01122, TIGR00285, COG1581 | NA | NA |
| UHGV-0025247_61 | KOfam | K01520 | dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] | NA |
| UHGV-0025247_61 | PHROG | phrog_135 | dUTPase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_61 | UniRef90 | UniRef90_A0A847P854 | dUTP diphosphatase | NA |
| UHGV-0025247_61 | eggNOG-mapper | 357809.Cphy_3038 | dUTPase | NA |
| UHGV-0025247_61 | Pfam | PF00692 | dUTPase | dUTPase |
| UHGV-0025247_61 | NCBIFam | TIGR00576.1 | dUTP diphosphatase | NA |
| UHGV-0025247_61 | COG | COG0756 | dUTP pyrophosphatase (dUTPase) | NA |
| UHGV-0025247_61 | Structural annotation | PF00692, MF_00116, NF001862, COG0756 | NA | NA |
| UHGV-0025247_62 | KOfam | K01159 | ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10] | NA |
| UHGV-0025247_62 | PHROG | phrog_827 | Holliday junction resolvase | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_62 | UniRef90 | UniRef90_A0A345BPU5 | Crossover junction endodeoxyribonuclease RuvC | NA |
| UHGV-0025247_62 | eggNOG-mapper | 871968.DESME_08990 | NA | NA |
| UHGV-0025247_62 | Pfam | PF02075 | Crossover junction endodeoxyribonuclease RuvC | RuvC |
| UHGV-0025247_62 | Structural annotation | PF07066, MF_00034, NF000711, COG0817 | NA | NA |
| UHGV-0025247_63 | PHROG | phrog_1233 | NA | unknown function |
| UHGV-0025247_63 | UniRef90 | UniRef90_A0A345BPX6 | Metal-dependent hydrolase | NA |
| UHGV-0025247_63 | eggNOG-mapper | 658655.HMPREF0988_00914 | NA | NA |
| UHGV-0025247_63 | Pfam | PF06114 | IrrE N-terminal-like domain | Peptidase_M78 |
| UHGV-0025247_64 | eggNOG-mapper | 658655.HMPREF0988_00915 | NA | NA |
| UHGV-0025247_65 | PHROG | phrog_20016 | NA | unknown function |
| UHGV-0025247_65 | UniRef90 | UniRef90_A0A345BPX4 | Carbohydrate binding domain/collagen triple helix repeat protein | NA |
| UHGV-0025247_65 | eggNOG-mapper | 1226322.HMPREF1545_00077 | NA | NA |
| UHGV-0025247_65 | Structural annotation | PF18573, NF033147 | NA | NA |
| UHGV-0025247_66 | PHROG | phrog_16490 | NA | unknown function |
| UHGV-0025247_66 | eggNOG-mapper | 397290.C810_05212 | NA | NA |
| UHGV-0025247_67 | eggNOG-mapper | 476272.RUMHYD_01953 | NA | NA |
| UHGV-0025247_68 | eggNOG-mapper | 445972.ANACOL_01878 | NA | NA |
| UHGV-0025247_68 | Structural annotation | NF033819 | NA | NA |
| UHGV-0025247_69 | PHROG | phrog_32343 | NA | unknown function |
| UHGV-0025247_69 | UniRef90 | UniRef90_A0A345BPW9 | Putative flagellin-like protein | NA |
| UHGV-0025247_69 | eggNOG-mapper | 1304866.K413DRAFT_4764 | NA | NA |
| UHGV-0025247_69 | Structural annotation | PF14594, NF033848, COG4379 | NA | NA |
| UHGV-0025247_72 | eggNOG-mapper | 1410625.JHWK01000005_gene1354 | NA | NA |
| UHGV-0025247_73 | PHROG | phrog_1401 | NA | unknown function |
| UHGV-0025247_73 | eggNOG-mapper | 1294142.CINTURNW_1041 | NA | NA |
| UHGV-0025247_73 | Structural annotation | PF07761 | NA | NA |
| UHGV-0025247_75 | KOfam | K20478 | GOLGB1; golgin subfamily B member 1 | NA |
| UHGV-0025247_75 | PHROG | phrog_4211 | tail length tape measure protein | tail |
| UHGV-0025247_75 | eggNOG-mapper | 10736.A0A1P8CWQ1_BPPHT | peptidoglycan catabolic process | NA |
| UHGV-0025247_75 | Pfam | PF10145 | Phage-related minor tail protein | PhageMin_Tail |
| UHGV-0025247_75 | NCBIFam | TIGR01760.1 | phage tail tape measure protein | NA |
| UHGV-0025247_78 | PHROG | phrog_2729 | virion structural protein | head and packaging |
| UHGV-0025247_78 | eggNOG-mapper | 1196323.ALKF01000158_gene820 | NA | NA |
| UHGV-0025247_79 | PHROG | phrog_4051 | NA | unknown function |
| UHGV-0025247_80 | PHROG | phrog_6123 | virion structural protein | head and packaging |
| UHGV-0025247_80 | Structural annotation | PF06141 | NA | NA |
| UHGV-0025247_81 | UniRef90 | UniRef90_A0A345BPV9 | Ig domain protein | NA |
| UHGV-0025247_81 | Structural annotation | PF19408, PF11649, NF041894, COG5614 | NA | NA |
| UHGV-0025247_82 | PHROG | phrog_29637 | NA | unknown function |
| UHGV-0025247_82 | Structural annotation | PF14276 | NA | NA |
| UHGV-0025247_83 | PHROG | phrog_3853 | NA | unknown function |
| UHGV-0025247_83 | eggNOG-mapper | 97139.C824_00204 | NA | NA |
| UHGV-0025247_84 | PHROG | phrog_30998 | NA | unknown function |
| UHGV-0025247_85 | PHROG | phrog_4088 | NA | unknown function |
| UHGV-0025247_85 | eggNOG-mapper | 1541960.KQ78_01850 | NA | NA |
| UHGV-0025247_85 | Structural annotation | PF05065, MF_04119, TIGR01554, COG4653 | NA | NA |
| UHGV-0025247_87 | PHROG | phrog_3313 | NA | unknown function |
| UHGV-0025247_87 | eggNOG-mapper | 1308863.U5J9D4_9CAUD | NA | NA |
| UHGV-0025247_87 | Structural annotation | PF09979, TIGR01543, COG3566 | NA | NA |
| UHGV-0025247_88 | PHROG | phrog_2739 | portal protein | head and packaging |
| UHGV-0025247_88 | UniRef90 | UniRef90_A0A345BPV2 | Putative portal protein | NA |
| UHGV-0025247_88 | eggNOG-mapper | 881953.E0YJ33_9CAUD | NA | NA |
| UHGV-0025247_88 | Structural annotation | PF05133, MF_04135, TIGR01537, COG4695 | NA | NA |
| UHGV-0025247_89 | PHROG | phrog_9084 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0025247_89 | UniRef90 | UniRef90_UPI001CDB5F86 | endonuclease domain-containing protein | NA |
| UHGV-0025247_89 | eggNOG-mapper | 666686.B1NLA3E_15725 | Restriction endonuclease | NA |
| UHGV-0025247_89 | COG | COG3440 | Predicted restriction endonuclease | NA |
| UHGV-0025247_89 | Structural annotation | PF18741, MF_04160, NF007294, COG2852 | NA | NA |
| UHGV-0025247_90 | PHROG | phrog_15503 | NA | unknown function |
| UHGV-0025247_90 | UniRef90 | UniRef90_A0A0H3V0N0 | Putative terminase large subunit | NA |
| UHGV-0025247_90 | eggNOG-mapper | 1308863.U5J9B2_9CAUD | NA | NA |
| UHGV-0025247_90 | Structural annotation | PF20441, PF04466, MF_04146, TIGR01547, COG4626 | NA | NA |
| UHGV-0025247_91 | PHROG | phrog_3314 | NA | unknown function |
| UHGV-0025247_91 | eggNOG-mapper | 1308863.U5J9N3_9CAUD | NA | NA |
| UHGV-0025247_92 | PHROG | phrog_5767 | sigma factor | transcription regulation |
| UHGV-0025247_92 | UniRef90 | UniRef90_A0A345BPU6 | HTH DNA binding domain protein | NA |
| UHGV-0025247_92 | eggNOG-mapper | 1123239.KB898628_gene3218 | NA | NA |
| UHGV-0025247_93 | PHROG | phrog_3848 | NA | unknown function |
| UHGV-0025247_97 | PHROG | phrog_2643 | 5'-3' deoxyribonucleotidase | moron, auxiliary metabolic gene and host takeover |
| UHGV-0025247_97 | UniRef90 | UniRef90_UPI000F529FDC | 5'-nucleotidase | NA |
| UHGV-0025247_97 | eggNOG-mapper | 1280688.AUJB01000009_gene1677 | 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) | NA |
| UHGV-0025247_97 | Pfam | PF06941 | 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) | NT5C |
| UHGV-0025247_97 | Structural annotation | PF06941, MF_01681, NF011564, COG4502 | NA | NA |
| UHGV-0025247_104 | Structural annotation | PF18350, MF_01354, TIGR00405, COG2139 | NA | NA |
| UHGV-0025247_106 | KOfam | K08073 | PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] | NA |
| UHGV-0025247_106 | PHROG | phrog_6931 | NA | unknown function |
| UHGV-0025247_106 | UniRef90 | UniRef90_UPI001F554BE5 | AAA family ATPase | NA |
| UHGV-0025247_106 | eggNOG-mapper | 1173024.KI912151_gene2263 | Chromatin associated protein KTI12 | NA |
| UHGV-0025247_106 | Pfam | PF13671 | AAA domain | AAA_33 |
| UHGV-0025247_106 | COG | COG4639 | Predicted kinase | NA |
| UHGV-0025247_106 | Structural annotation | PF13671, MF_00065, TIGR03574, COG4088 | NA | NA |
| UHGV-0025247_108 | Pfam | PF03889 | Alternative ribosome-rescue factor A | ArfA |
| UHGV-0025247_112 | Structural annotation | PF00679, MF_01515, NF003194, COG4843 | NA | NA |
| UHGV-0025247_113 | Structural annotation | PF07106, MF_01177, NF033788, COG0640 | NA | NA |
| UHGV-0025247_114 | PHROG | phrog_20187 | NA | unknown function |
| UHGV-0025247_114 | UniRef90 | UniRef90_A0A345BPQ2 | Putative Pol III-like exoribonuclease | NA |
| UHGV-0025247_114 | Structural annotation | PF21762, MF_00045, NF006316, COG0847 | NA | NA |
| UHGV-0025247_115 | Structural annotation | PF07106, MF_01177, NF033788, COG0640 | NA | NA |
| UHGV-0025247_125 | eggNOG-mapper | 1528098.NOVO_05375 | NA | NA |
| UHGV-0025247_125 | Pfam | PF03013 | Pyrimidine dimer DNA glycosylase | Pyr_excise |
| UHGV-0025247_125 | Structural annotation | PF03013, NF038085 | NA | NA |
| UHGV-0025247_128 | KOfam | K01491 | folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] | NA |
| UHGV-0025247_128 | PHROG | phrog_7320 | tetrahydrofolate dehydrogenase and cyclohydrolase | other |
| UHGV-0025247_128 | UniRef90 | UniRef90_A0A2E6H2X4 | Bifunctional protein FolD | NA |
| UHGV-0025247_128 | eggNOG-mapper | 1122216.AUHW01000027_gene1967 | Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate | NA |
| UHGV-0025247_128 | Pfam | PF00763 | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | THF_DHG_CYH |
| UHGV-0025247_128 | Pfam | PF02882 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | THF_DHG_CYH_C |
| UHGV-0025247_128 | COG | COG0190 | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | NA |
| UHGV-0025247_128 | HAMAP | MF_01576 | Bifunctional protein FolD [folD] | NA |
| UHGV-0025247_128 | Structural annotation | PF02882, PF00763, MF_01576, NF010775, COG0190 | NA | NA |
| UHGV-0025247_132 | PHROG | phrog_30451 | NA | unknown function |
| UHGV-0025247_132 | UniRef90 | UniRef90_UPI000BFDF27B | zinc finger-like domain-containing protein | NA |
| UHGV-0025247_132 | Structural annotation | PF21473, NF005049 | NA | NA |
| UHGV-0025247_135 | Structural annotation | PF19110, MF_01909, NF040939, COG1695 | NA | NA |
| UHGV-0025247_136 | Structural annotation | PF02581, MF_02232, TIGR01182, COG0135 | NA | NA |
| UHGV-0025247_137 | PHROG | phrog_21992 | esterase/lipase | other |
| UHGV-0025247_137 | UniRef90 | UniRef90_A0A1C6IQW1 | Predicted lipase | NA |
| UHGV-0025247_137 | eggNOG-mapper | 158189.SpiBuddy_1874 | Lipase (class 3) | NA |
| UHGV-0025247_137 | Pfam | PF01764 | Lipase (class 3) | Lipase_3 |
| UHGV-0025247_137 | COG | COG3675 | Predicted lipase | NA |
| UHGV-0025247_137 | Structural annotation | PF01764, NF041407, COG3675 | NA | NA |
| UHGV-0025247_139 | eggNOG-mapper | 573061.Clocel_0829 | Calcineurin-like phosphoesterase | NA |
| UHGV-0025247_139 | COG | COG1409 | 3',5'-cyclic AMP phosphodiesterase CpdA | NA |
| UHGV-0025247_155 | PHROG | phrog_1479 | NA | unknown function |
| UHGV-0025247_155 | eggNOG-mapper | 1410630.JNKP01000003_gene989 | NA | NA |
| UHGV-0025247_155 | Pfam | PF20274 | Cyclic-phosphate processing Receiver domain | cREC_REC |
| UHGV-0025247_155 | Structural annotation | PF20274 | NA | NA |