| UHGV-0031718_6 | PHROG | phrog_20187 | NA | unknown function |
| UHGV-0031718_6 | UniRef90 | UniRef90_A0A345BPQ2 | Putative Pol III-like exoribonuclease | NA |
| UHGV-0031718_6 | Structural annotation | PF21762, MF_00045, NF006316, COG0847 | NA | NA |
| UHGV-0031718_9 | Structural annotation | PF11019, MF_01022, NF003937, COG4502 | NA | NA |
| UHGV-0031718_12 | Structural annotation | PF08962 | NA | NA |
| UHGV-0031718_18 | Structural annotation | PF11429 | NA | NA |
| UHGV-0031718_20 | KOfam | K04769 | spoVT; AbrB family transcriptional regulator, stage V sporulation protein T | NA |
| UHGV-0031718_20 | PHROG | phrog_4681 | antitoxin from a toxin-antitoxin system | moron, auxiliary metabolic gene and host takeover |
| UHGV-0031718_20 | UniRef90 | UniRef90_A0A8A5ZJD8 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | NA |
| UHGV-0031718_20 | eggNOG-mapper | 1235835.C814_03375 | stage V sporulation protein T | NA |
| UHGV-0031718_20 | Pfam | PF04014 | Antidote-toxin recognition MazE, bacterial antitoxin | MazE_antitoxin |
| UHGV-0031718_20 | NCBIFam | TIGR01439.1 | transcriptional regulator, AbrB family | NA |
| UHGV-0031718_20 | COG | COG2002 | Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module | NA |
| UHGV-0031718_20 | Structural annotation | PF04014, TIGR01439, COG2002 | NA | NA |
| UHGV-0031718_31 | PHROG | phrog_5767 | sigma factor | transcription regulation |
| UHGV-0031718_31 | UniRef90 | UniRef90_A0A345BPU6 | HTH DNA binding domain protein | NA |
| UHGV-0031718_32 | PHROG | phrog_3314 | NA | unknown function |
| UHGV-0031718_32 | eggNOG-mapper | 1308863.U5J9N3_9CAUD | NA | NA |
| UHGV-0031718_33 | PHROG | phrog_15503 | NA | unknown function |
| UHGV-0031718_33 | UniRef90 | UniRef90_A0A0H3V0N0 | Putative terminase large subunit | NA |
| UHGV-0031718_33 | eggNOG-mapper | 1308863.U5J9B2_9CAUD | NA | NA |
| UHGV-0031718_33 | Structural annotation | PF20441, PF04466, MF_04146, TIGR01547, COG4626 | NA | NA |
| UHGV-0031718_35 | PHROG | phrog_2739 | portal protein | head and packaging |
| UHGV-0031718_35 | UniRef90 | UniRef90_A0A345BPV2 | Putative portal protein | NA |
| UHGV-0031718_35 | eggNOG-mapper | 665956.HMPREF1032_03237 | NA | NA |
| UHGV-0031718_35 | Structural annotation | PF05133, MF_04135, TIGR01537, COG4695 | NA | NA |
| UHGV-0031718_36 | PHROG | phrog_3313 | NA | unknown function |
| UHGV-0031718_36 | UniRef90 | UniRef90_A0A843FJ52 | HALZ domain-containing protein | NA |
| UHGV-0031718_36 | eggNOG-mapper | 574375.BAGA_05920 | NA | NA |
| UHGV-0031718_36 | Structural annotation | PF04586, TIGR01543, COG3566 | NA | NA |
| UHGV-0031718_37 | PHROG | phrog_35301 | NA | unknown function |
| UHGV-0031718_38 | PHROG | phrog_4088 | NA | unknown function |
| UHGV-0031718_38 | eggNOG-mapper | 1541960.KQ78_01850 | NA | NA |
| UHGV-0031718_38 | Structural annotation | PF05065, MF_04119, TIGR01554, COG4653 | NA | NA |
| UHGV-0031718_40 | PHROG | phrog_3853 | NA | unknown function |
| UHGV-0031718_41 | PHROG | phrog_29637 | NA | unknown function |
| UHGV-0031718_42 | PHROG | phrog_31155 | NA | unknown function |
| UHGV-0031718_42 | Structural annotation | PF19408, PF11649, NF041894, COG5614 | NA | NA |
| UHGV-0031718_43 | PHROG | phrog_6123 | virion structural protein | head and packaging |
| UHGV-0031718_43 | Structural annotation | PF06141 | NA | NA |
| UHGV-0031718_44 | PHROG | phrog_4051 | NA | unknown function |
| UHGV-0031718_45 | PHROG | phrog_2729 | virion structural protein | head and packaging |
| UHGV-0031718_45 | eggNOG-mapper | 1163671.JAGI01000002_gene1222 | NA | NA |
| UHGV-0031718_48 | KOfam | K20283 | GOLGA4; golgin subfamily A member 4 | NA |
| UHGV-0031718_48 | PHROG | phrog_4211 | tail length tape measure protein | tail |
| UHGV-0031718_48 | eggNOG-mapper | 881953.E0YJ17_9CAUD | peptidoglycan catabolic process | NA |
| UHGV-0031718_48 | Pfam | PF10145 | Phage-related minor tail protein | PhageMin_Tail |
| UHGV-0031718_48 | NCBIFam | TIGR01760.1 | phage tail tape measure protein | NA |
| UHGV-0031718_49 | Structural annotation | PF02010, MF_00075, MF_04116, NF040788 | NA | NA |
| UHGV-0031718_50 | Pfam | PF09479 | Listeria-Bacteroides repeat domain (List_Bact_rpt) | Flg_new |
| UHGV-0031718_50 | COG | COG2247 | Putative cell wall-binding domain (amidase enhancer), LytB superfamily | NA |
| UHGV-0031718_50 | Structural annotation | NF033189 | NA | NA |
| UHGV-0031718_51 | Structural annotation | PF19077, PF19266, PF13157, PF00041, MF_04116, MF_01591, NF041335, COG3499, COG2372 | NA | NA |
| UHGV-0031718_52 | PHROG | phrog_32343 | NA | unknown function |
| UHGV-0031718_52 | UniRef90 | UniRef90_A0A345BPW9 | Putative flagellin-like protein | NA |
| UHGV-0031718_52 | eggNOG-mapper | 1235800.C819_00529 | NA | NA |
| UHGV-0031718_52 | Structural annotation | PF05113, NF033848, COG4379 | NA | NA |
| UHGV-0031718_54 | eggNOG-mapper | 1519439.JPJG01000060_gene1892 | Collagen triple helix repeat (20 copies) | NA |
| UHGV-0031718_54 | COG | COG3064 | Membrane protein TolA involved in colicin uptake | NA |
| UHGV-0031718_58 | PHROG | phrog_5302 | tail protein | tail |
| UHGV-0031718_58 | UniRef90 | UniRef90_R6M197 | Ig-like_bact domain-containing protein | NA |
| UHGV-0031718_58 | eggNOG-mapper | 1203606.HMPREF1526_00261 | cellulose 1,4-beta-cellobiosidase activity | NA |
| UHGV-0031718_58 | COG | COG5301 | Phage-related tail fiber protein | NA |
| UHGV-0031718_58 | Structural annotation | COG1262 | NA | NA |
| UHGV-0031718_61 | Pfam | PF09682 | Bacteriophage holin of superfamily 6 (Holin_LLH) | Phage_holin_6_1 |
| UHGV-0031718_61 | Structural annotation | PF09682, TIGR01673 | NA | NA |
| UHGV-0031718_63 | eggNOG-mapper | 476272.RUMHYD_01953 | NA | NA |
| UHGV-0031718_64 | PHROG | phrog_16490 | NA | unknown function |
| UHGV-0031718_64 | eggNOG-mapper | 1408437.JNJN01000043_gene803 | NA | NA |
| UHGV-0031718_65 | PHROG | phrog_20016 | NA | unknown function |
| UHGV-0031718_65 | UniRef90 | UniRef90_A0A345BPX4 | Carbohydrate binding domain/collagen triple helix repeat protein | NA |
| UHGV-0031718_65 | eggNOG-mapper | 1226322.HMPREF1545_00077 | NA | NA |
| UHGV-0031718_65 | Structural annotation | PF18573, NF033147 | NA | NA |
| UHGV-0031718_66 | eggNOG-mapper | 658655.HMPREF0988_00915 | NA | NA |
| UHGV-0031718_67 | PHROG | phrog_1233 | NA | unknown function |
| UHGV-0031718_67 | UniRef90 | UniRef90_A0A345BPX6 | Metal-dependent hydrolase | NA |
| UHGV-0031718_67 | eggNOG-mapper | 658655.HMPREF0988_00914 | NA | NA |
| UHGV-0031718_69 | eggNOG-mapper | 871968.DESME_08990 | NA | NA |
| UHGV-0031718_70 | KOfam | K01520 | dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] | NA |
| UHGV-0031718_70 | PHROG | phrog_135 | dUTPase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_70 | UniRef90 | UniRef90_A0A8D9UHK3 | dUTPase | NA |
| UHGV-0031718_70 | eggNOG-mapper | 622312.ROSEINA2194_00085 | This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA | NA |
| UHGV-0031718_70 | Pfam | PF00692 | dUTPase | dUTPase |
| UHGV-0031718_70 | NCBIFam | TIGR00576.1 | dUTP diphosphatase | NA |
| UHGV-0031718_70 | COG | COG0756 | dUTP pyrophosphatase (dUTPase) | NA |
| UHGV-0031718_70 | Structural annotation | PF00692, MF_00116, TIGR00576, COG0756 | NA | NA |
| UHGV-0031718_72 | Structural annotation | PF14639, MF_00651, NF001026, COG0816 | NA | NA |
| UHGV-0031718_75 | KOfam | K00525 | E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] | NA |
| UHGV-0031718_75 | PHROG | phrog_84 | ribonucleoside-diphosphate reductase large subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_75 | UniRef90 | UniRef90_UPI00085BFD37 | adenosylcobalamin-dependent ribonucleoside-diphosphate reductase | NA |
| UHGV-0031718_75 | eggNOG-mapper | 537013.CLOSTMETH_03946 | Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen | NA |
| UHGV-0031718_75 | Pfam | PF02867 | Ribonucleotide reductase, barrel domain | Ribonuc_red_lgC |
| UHGV-0031718_75 | COG | COG0209 | Ribonucleotide reductase alpha subunit | NA |
| UHGV-0031718_75 | Structural annotation | PF02867, MF_04026, NF006417, COG0209 | NA | NA |
| UHGV-0031718_76 | KOfam | K00942 | gmk, GUK1; guanylate kinase [EC:2.7.4.8] | NA |
| UHGV-0031718_76 | PHROG | phrog_1815 | guanylate kinase | other |
| UHGV-0031718_76 | UniRef90 | UniRef90_A0A401UTJ7 | Guanylate kinase | NA |
| UHGV-0031718_76 | eggNOG-mapper | 742733.HMPREF9469_00862 | Guanylate kinase homologues. | NA |
| UHGV-0031718_76 | Pfam | PF00625 | Guanylate kinase | Guanylate_kin |
| UHGV-0031718_76 | COG | COG0194 | Guanylate kinase | NA |
| UHGV-0031718_76 | Structural annotation | PF00625, MF_00328, TIGR03263, COG0194 | NA | NA |
| UHGV-0031718_77 | KOfam | K02337 | dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] | NA |
| UHGV-0031718_77 | PHROG | phrog_405 | DNA polymerase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_77 | UniRef90 | UniRef90_A0A843FMN7 | DNA-directed DNA polymerase | NA |
| UHGV-0031718_77 | eggNOG-mapper | 224308.BSU20340 | DNA polymerase | NA |
| UHGV-0031718_77 | Pfam | PF02811 | PHP domain | PHP |
| UHGV-0031718_77 | Pfam | PF07733 | Bacterial DNA polymerase III alpha NTPase domain | DNA_pol3_alpha |
| UHGV-0031718_77 | Pfam | PF17657 | Bacterial DNA polymerase III alpha subunit finger domain | DNA_pol3_finger |
| UHGV-0031718_77 | Pfam | PF14579 | Helix-hairpin-helix motif | HHH_6 |
| UHGV-0031718_77 | COG | COG0587 | DNA polymerase III, alpha subunit | NA |
| UHGV-0031718_77 | Structural annotation | PF07733, PF02811, PF17657, PF14579, MF_01902, NF005617, COG0587 | NA | NA |
| UHGV-0031718_78 | Structural annotation | PF04466, TIGR00090 | NA | NA |
| UHGV-0031718_79 | KOfam | K03581 | recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] | NA |
| UHGV-0031718_79 | PHROG | phrog_325 | Dda-like helicase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_79 | UniRef90 | UniRef90_A0A843GQ82 | AAA family ATPase | NA |
| UHGV-0031718_79 | eggNOG-mapper | 1541960.KQ78_01910 | A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD | NA |
| UHGV-0031718_79 | PADLOC | cluster10 | RecD_0_IVD | CRISPR-CAS |
| UHGV-0031718_79 | Pfam | PF13604 | AAA domain | AAA_30 |
| UHGV-0031718_79 | Pfam | PF13538 | UvrD-like helicase C-terminal domain | UvrD_C_2 |
| UHGV-0031718_79 | COG | COG0507 | ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) | NA |
| UHGV-0031718_79 | Structural annotation | PF13604, MF_01488, TIGR01448, COG0507 | NA | NA |
| UHGV-0031718_81 | UniRef90 | UniRef90_A0A843FTG5 | Phage_lysozyme2 domain-containing protein | NA |
| UHGV-0031718_81 | Pfam | PF18013 | Phage tail lysozyme | Phage_lysozyme2 |
| UHGV-0031718_81 | COG | COG3583 | NA | NA |
| UHGV-0031718_81 | Structural annotation | PF18013, PF02185, NF001260 | NA | NA |
| UHGV-0031718_82 | KOfam | K07462 | recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] | NA |
| UHGV-0031718_82 | PHROG | phrog_2484 | RecJ-like ssDNA exonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_82 | UniRef90 | UniRef90_A0A843FU26 | DHH family phosphoesterase | NA |
| UHGV-0031718_82 | eggNOG-mapper | 665956.HMPREF1032_03163 | exonuclease | NA |
| UHGV-0031718_82 | Pfam | PF01368 | DHH family | DHH |
| UHGV-0031718_82 | Pfam | PF17768 | RecJ OB domain | RecJ_OB |
| UHGV-0031718_82 | COG | COG0608 | ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation | NA |
| UHGV-0031718_82 | Structural annotation | PF17768, PF02272, MF_00207, TIGR00644, COG0608 | NA | NA |
| UHGV-0031718_83 | KOfam | K02316 | dnaG; DNA primase [EC:2.7.7.101] | NA |
| UHGV-0031718_83 | PHROG | phrog_47 | DNA primase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_83 | UniRef90 | UniRef90_A0A345BPU0 | DNA primase | NA |
| UHGV-0031718_83 | eggNOG-mapper | 1280.SAXN108_2224 | DNA primase activity | NA |
| UHGV-0031718_83 | COG | COG0358 | DNA primase (bacterial type) | NA |
| UHGV-0031718_83 | Structural annotation | PF01807, PF19898, MF_00974, NF006382, COG0358 | NA | NA |
| UHGV-0031718_85 | KOfam | K02314 | dnaB; replicative DNA helicase [EC:5.6.2.3] | NA |
| UHGV-0031718_85 | PHROG | phrog_19 | DnaB-like replicative helicase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_85 | UniRef90 | UniRef90_A0A843FVR3 | DNA helicase | NA |
| UHGV-0031718_85 | eggNOG-mapper | 224308.BSU20370 | DnaB-like helicase C terminal domain | NA |
| UHGV-0031718_85 | Pfam | PF00772 | DnaB-like helicase N terminal domain | DnaB |
| UHGV-0031718_85 | Pfam | PF03796 | DnaB-like helicase C terminal domain | DnaB_C |
| UHGV-0031718_85 | COG | COG0305 | Replicative DNA helicase | NA |
| UHGV-0031718_85 | Structural annotation | PF03796, PF00772, MF_04155, TIGR00665, COG0305 | NA | NA |
| UHGV-0031718_86 | PHROG | phrog_124 | Sak4-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_86 | UniRef90 | UniRef90_A0A843GMB3 | ATP-binding protein | NA |
| UHGV-0031718_86 | eggNOG-mapper | 1541960.KQ78_01919 | Belongs to the helicase family. UvrD subfamily | NA |
| UHGV-0031718_86 | Pfam | PF13479 | AAA domain | AAA_24 |
| UHGV-0031718_86 | COG | COG2887 | RecB family exonuclease | NA |
| UHGV-0031718_86 | Structural annotation | PF13479, MF_00350, TIGR01618, COG0468 | NA | NA |
| UHGV-0031718_87 | PHROG | phrog_4645 | endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_87 | UniRef90 | UniRef90_A0A345BQ04 | LAGLIDADG-like domain protein | NA |
| UHGV-0031718_87 | eggNOG-mapper | 1235659.S4T8V2_9CAUD | N-acetyltransferase activity | NA |
| UHGV-0031718_87 | Pfam | PF14528 | LAGLIDADG-like domain | LAGLIDADG_3 |
| UHGV-0031718_87 | Structural annotation | PF03161, PF02796, MF_01420, TIGR00647, TIGR04381, COG1372 | NA | NA |
| UHGV-0031718_89 | Structural annotation | PF00436, PF19649, MF_00984, NF004476, COG2965 | NA | NA |
| UHGV-0031718_90 | KOfam | K03465 | thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] | NA |
| UHGV-0031718_90 | PHROG | phrog_85 | thymidylate synthase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_90 | UniRef90 | UniRef90_A0A7X2NTD7 | FAD-dependent thymidylate synthase | NA |
| UHGV-0031718_90 | eggNOG-mapper | 1282887.AUJG01000001_gene1906 | thymidylate synthase (FAD) activity | NA |
| UHGV-0031718_90 | Pfam | PF02511 | Thymidylate synthase complementing protein | Thy1 |
| UHGV-0031718_90 | COG | COG1351 | Thymidylate synthase ThyX, FAD-dependent family | NA |
| UHGV-0031718_90 | Structural annotation | PF02511, MF_01408, TIGR02170, COG1351 | NA | NA |
| UHGV-0031718_91 | PHROG | phrog_314 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_91 | UniRef90 | UniRef90_A0A345BPZ2 | GIY-YIG domain-containing protein | NA |
| UHGV-0031718_91 | PADLOC | HEase_00030 | homing endonuclease | RM |
| UHGV-0031718_91 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-0031718_91 | NCBIFam | TIGR01453.1 | group I intron endonuclease | NA |
| UHGV-0031718_91 | COG | COG3860 | NA | NA |
| UHGV-0031718_91 | Structural annotation | PF19835, TIGR01453 | NA | NA |
| UHGV-0031718_92 | Structural annotation | PF04182, MF_01909, NF040939, COG1675 | NA | NA |
| UHGV-0031718_95 | KOfam | K10747 | LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] | NA |
| UHGV-0031718_95 | PHROG | phrog_114 | ATP-dependent DNA ligase | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_95 | UniRef90 | UniRef90_A0A345BPZ1 | DNA ligase | NA |
| UHGV-0031718_95 | eggNOG-mapper | 1121121.KB894295_gene4492 | dna ligase | NA |
| UHGV-0031718_95 | Pfam | PF01068 | ATP dependent DNA ligase domain | DNA_ligase_A_M |
| UHGV-0031718_95 | COG | COG1793 | ATP-dependent DNA ligase | NA |
| UHGV-0031718_95 | Structural annotation | PF01068, MF_00407, TIGR02779, COG1793 | NA | NA |
| UHGV-0031718_96 | KOfam | K02469 | gyrA; DNA gyrase subunit A [EC:5.6.2.2] | NA |
| UHGV-0031718_96 | PHROG | phrog_551 | DNA topoisomerase II | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_96 | UniRef90 | UniRef90_A0A832SNJ2 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-0031718_96 | eggNOG-mapper | 1541960.KQ78_01979 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-0031718_96 | Pfam | PF00521 | DNA gyrase/topoisomerase IV, subunit A | DNA_topoisoIV |
| UHGV-0031718_96 | Pfam | PF03989 | DNA gyrase C-terminal domain, beta-propeller | DNA_gyraseA_C |
| UHGV-0031718_96 | COG | COG0188 | DNA gyrase/topoisomerase IV, subunit A | NA |
| UHGV-0031718_96 | Structural annotation | PF00521, PF03989, MF_01897, NF004043, COG0188 | NA | NA |
| UHGV-0031718_97 | KOfam | K02470 | gyrB; DNA gyrase subunit B [EC:5.6.2.2] | NA |
| UHGV-0031718_97 | PHROG | phrog_543 | DNA topoisomerase II large subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_97 | UniRef90 | UniRef90_A0A345BPY9 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-0031718_97 | eggNOG-mapper | 689781.AUJX01000045_gene2658 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-0031718_97 | Pfam | PF02518 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | HATPase_c |
| UHGV-0031718_97 | Pfam | PF00204 | DNA gyrase B | DNA_gyraseB |
| UHGV-0031718_97 | Pfam | PF01751 | Toprim domain | Toprim |
| UHGV-0031718_97 | Pfam | PF00986 | DNA gyrase B subunit, carboxyl terminus | DNA_gyraseB_C |
| UHGV-0031718_97 | COG | COG0187 | DNA gyrase/topoisomerase IV, subunit B | NA |
| UHGV-0031718_97 | Structural annotation | PF00204, MF_01898, TIGR01059, COG0187 | NA | NA |
| UHGV-0031718_98 | KOfam | K03469 | rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] | NA |
| UHGV-0031718_98 | PHROG | phrog_531 | Rnase H | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_98 | UniRef90 | UniRef90_A0A843FJ64 | Ribonuclease H | NA |
| UHGV-0031718_98 | eggNOG-mapper | 1121451.DESAM_20563 | Endonuclease that specifically degrades the RNA of RNA- DNA hybrids | NA |
| UHGV-0031718_98 | Pfam | PF00075 | RNase H | RNase_H |
| UHGV-0031718_98 | COG | COG0328 | Ribonuclease HI | NA |
| UHGV-0031718_98 | Structural annotation | PF00075, MF_00042, NF001236, COG0328 | NA | NA |
| UHGV-0031718_100 | KOfam | K21470 | ycbB; L,D-transpeptidase YcbB | NA |
| UHGV-0031718_100 | PHROG | phrog_9589 | endolysin | lysis |
| UHGV-0031718_100 | eggNOG-mapper | 552398.HMPREF0866_03091 | CHAP domain | NA |
| UHGV-0031718_100 | Pfam | PF01471 | Putative peptidoglycan binding domain | PG_binding_1 |
| UHGV-0031718_100 | Pfam | PF05257 | CHAP domain | CHAP |
| UHGV-0031718_100 | Pfam | PF08239 | Bacterial SH3 domain | SH3_3 |
| UHGV-0031718_100 | COG | COG0791 | Cell wall-associated hydrolase, NlpC_P60 family | NA |
| UHGV-0031718_101 | KOfam | K07175 | phoH2; PhoH-like ATPase | NA |
| UHGV-0031718_101 | PHROG | phrog_2765 | PhoH-like phosphate starvation-inducible | other |
| UHGV-0031718_101 | UniRef90 | UniRef90_A0A1C5UCD2 | PhoH-like protein | NA |
| UHGV-0031718_101 | eggNOG-mapper | 1123252.ATZF01000010_gene420 | PIN domain | NA |
| UHGV-0031718_101 | Pfam | PF13638 | PIN domain | PIN_4 |
| UHGV-0031718_101 | Pfam | PF02562 | PhoH-like protein | PhoH |
| UHGV-0031718_101 | COG | COG1875 | Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains | NA |
| UHGV-0031718_101 | Structural annotation | PF02562, PF13638, PF09142, MF_00265, NF007827, NF009148, COG1875 | NA | NA |
| UHGV-0031718_104 | PHROG | phrog_547 | phosphoesterase | other |
| UHGV-0031718_104 | UniRef90 | UniRef90_A0A1I0M725 | Calcineurin-like phosphoesterase superfamily protein | NA |
| UHGV-0031718_104 | eggNOG-mapper | 445961.IW15_14075 | Calcineurin-like phosphoesterase superfamily domain | NA |
| UHGV-0031718_104 | COG | COG4186 | NA | NA |
| UHGV-0031718_104 | Structural annotation | PF12850, MF_00575, NF006988, COG4186 | NA | NA |
| UHGV-0031718_106 | PHROG | phrog_6931 | NA | unknown function |
| UHGV-0031718_106 | UniRef90 | UniRef90_A0A345BPY6 | AAA domain protein | NA |
| UHGV-0031718_106 | Pfam | PF13671 | AAA domain | AAA_33 |
| UHGV-0031718_106 | COG | COG4639 | Predicted kinase | NA |
| UHGV-0031718_106 | Structural annotation | PF13671, MF_00065, TIGR03574, COG4088 | NA | NA |
| UHGV-0031718_107 | PHROG | phrog_1257 | ribosome associated inhibitor A; zinc finger domain | moron, auxiliary metabolic gene and host takeover |
| UHGV-0031718_109 | Structural annotation | PF01978, MF_01177, NF008240, COG0735 | NA | NA |
| UHGV-0031718_112 | KOfam | K18961 | rnlA; T4 RNA ligase 1 [EC:6.5.1.3] | NA |
| UHGV-0031718_112 | PHROG | phrog_562 | RNA ligase and tail fiber protein attachment catalyst | tail |
| UHGV-0031718_112 | UniRef90 | UniRef90_A0A2G4F066 | 2'-5' RNA ligase | NA |
| UHGV-0031718_112 | eggNOG-mapper | 179408.Osc7112_2735 | RNA ligase | NA |
| UHGV-0031718_112 | Pfam | PF09511 | RNA ligase | RNA_lig_T4_1 |
| UHGV-0031718_112 | Structural annotation | PF09511, MF_04149, TIGR02308, COG5324 | NA | NA |
| UHGV-0031718_113 | PHROG | phrog_547 | phosphoesterase | other |
| UHGV-0031718_113 | UniRef90 | UniRef90_A0A843FNF2 | Metallophosphoesterase | NA |
| UHGV-0031718_113 | eggNOG-mapper | 1410632.JHWW01000019_gene1481 | NA | NA |
| UHGV-0031718_113 | Pfam | PF00149 | Calcineurin-like phosphoesterase | Metallophos |
| UHGV-0031718_113 | Structural annotation | MF_00575, TIGR04123, COG4186 | NA | NA |
| UHGV-0031718_115 | KOfam | K00600 | glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] | NA |
| UHGV-0031718_115 | PHROG | phrog_9968 | methyltransferase | other |
| UHGV-0031718_115 | UniRef90 | UniRef90_A0A354UC54 | Serine hydroxymethyltransferase | NA |
| UHGV-0031718_115 | eggNOG-mapper | 858215.Thexy_0455 | Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism | NA |
| UHGV-0031718_115 | Pfam | PF00464 | Serine hydroxymethyltransferase | SHMT |
| UHGV-0031718_115 | NCBIFam | NF000586.1 | serine hydroxymethyltransferase | NA |
| UHGV-0031718_115 | COG | COG0112 | Glycine/serine hydroxymethyltransferase | NA |
| UHGV-0031718_115 | HAMAP | MF_00051 | Serine hydroxymethyltransferase [glyA] | NA |
| UHGV-0031718_115 | Structural annotation | PF00464, MF_00051, NF000586, COG0112 | NA | NA |
| UHGV-0031718_119 | PHROG | phrog_22543 | NA | unknown function |
| UHGV-0031718_122 | Pfam | PF13240 | zinc-ribbon domain | zinc_ribbon_2 |
| UHGV-0031718_125 | PHROG | phrog_839 | NA | unknown function |
| UHGV-0031718_129 | KOfam | K07313 | pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16] | NA |
| UHGV-0031718_129 | PHROG | phrog_246 | NinI-like serine-threonine phosphatase | other |
| UHGV-0031718_129 | UniRef90 | UniRef90_R6LQ90 | Metallophos domain-containing protein | NA |
| UHGV-0031718_129 | eggNOG-mapper | 500633.CLOHIR_00780 | phosphoprotein phosphatase activity | NA |
| UHGV-0031718_129 | Pfam | PF00149 | Calcineurin-like phosphoesterase | Metallophos |
| UHGV-0031718_129 | COG | COG0639 | Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family | NA |
| UHGV-0031718_129 | Structural annotation | PF12850, MF_01443, NF007425, COG0622 | NA | NA |
| UHGV-0031718_133 | PHROG | phrog_1479 | NA | unknown function |
| UHGV-0031718_133 | eggNOG-mapper | 1256908.HMPREF0373_01589 | NA | NA |
| UHGV-0031718_133 | Pfam | PF20274 | Cyclic-phosphate processing Receiver domain | cREC_REC |
| UHGV-0031718_133 | Structural annotation | PF20274 | NA | NA |
| UHGV-0031718_134 | Structural annotation | PF01978, MF_01819, NF012168, COG0735 | NA | NA |
| UHGV-0031718_139 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-0031718_140 | PHROG | phrog_33094 | NA | unknown function |
| UHGV-0031718_141 | PHROG | phrog_35541 | NA | unknown function |
| UHGV-0031718_141 | UniRef90 | UniRef90_A0A3D6B2G4 | Mtd_N domain-containing protein | NA |
| UHGV-0031718_141 | eggNOG-mapper | 411470.RUMGNA_00120 | NA | NA |
| UHGV-0031718_141 | Structural annotation | PF18454 | NA | NA |
| UHGV-0031718_142 | PHROG | phrog_27786 | tail spike protein | tail |
| UHGV-0031718_142 | UniRef90 | UniRef90_A0A6J5LI95 | Mtd_N domain-containing protein | NA |
| UHGV-0031718_142 | eggNOG-mapper | 679935.Alfi_2724 | NA | NA |
| UHGV-0031718_142 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-0031718_142 | Structural annotation | PF18454 | NA | NA |
| UHGV-0031718_143 | Structural annotation | PF20010 | NA | NA |
| UHGV-0031718_144 | Structural annotation | PF13973, NF038082, COG4728 | NA | NA |
| UHGV-0031718_145 | Pfam | PF13529 | Peptidase_C39 like family | Peptidase_C39_2 |
| UHGV-0031718_145 | COG | COG3271 | Predicted double-glycine leader peptidase, C39-like (CLD) domain | NA |
| UHGV-0031718_147 | PHROG | phrog_2255 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0031718_147 | UniRef90 | UniRef90_A0A8J7C728 | HNH endonuclease | NA |
| UHGV-0031718_147 | eggNOG-mapper | 1541960.KQ78_01975 | HNH nucleases | NA |
| UHGV-0031718_147 | Structural annotation | PF18337 | NA | NA |
| UHGV-0031718_163 | Structural annotation | PF11314 | NA | NA |
| UHGV-0031718_167 | Structural annotation | PF02581, MF_02232, TIGR01182, COG0135 | NA | NA |
| UHGV-0031718_169 | eggNOG-mapper | 935948.KE386495_gene2241 | NA | NA |
| UHGV-0031718_171 | Structural annotation | PF04492, TIGR01610 | NA | NA |
| UHGV-0031718_172 | Structural annotation | PF18903 | NA | NA |