UHGV-0045054

Genome information

Genome length 50,502 bps

CDS count 87

Completeness 85.56% (medium-quality)

geNomad score 0.9799

Prediction confidence Confident

Genome information
Genome ID	UHGV-0045054
vOTU ID	vOTU-016501
vOTU representative	Yes
Source dataset	GPD
Original genome ID	uvig_3790
BioSample	SAMEA728749
Country	Unknown
Virus prediction confidence	Confident

Quality assessment
CheckV method	AAI-based
CheckV completeness	85.56% (medium-quality)
CheckV contamination	0.00%
Trimmed provirus	No
CheckV viral markers	22
CheckV host markers	0
Recoded stop codon	No

Viral signal
geNomad score	0.9799
Virus hallmark genes (geNomad)	14
Plasmid hallmark genes (geNomad)	0
viralVerify prediction	Virus
viralVerify score	57.19
Jumbo phage	No

Genome content
Genome length	50,502 bps
GC content	38.61%
Genetic code	The standard bacterial, archaeal and plant plastid code (11)
CDS count	87
CDS density	90.48%
Average CDS length	528.52 bps
tRNA count	3
Suppressor tRNA genes	0

Genome content

Select view: Genome viewer Functional annotation

Functional annotation

Gene ID	Reference	Reference ID	Information	Category
UHGV-0045054_1	KOfam	K14059	int; integrase	NA
UHGV-0045054_1	PHROG	phrog_1	integrase	integration and excision
UHGV-0045054_1	UniRef90	UniRef90_A0A412RQS9	Site-specific integrase	NA
UHGV-0045054_1	eggNOG-mapper	1235799.C818_02711	Phage integrase family	NA
UHGV-0045054_1	Pfam	PF02920	DNA binding domain of tn916 integrase	Integrase_DNA
UHGV-0045054_1	Pfam	PF14659	Phage integrase, N-terminal SAM-like domain	Phage_int_SAM_3
UHGV-0045054_1	Pfam	PF00589	Phage integrase family	Phage_integrase
UHGV-0045054_1	COG	COG0582	Integrase/recombinase, includes phage integrase	NA
UHGV-0045054_1	Structural annotation	PF00589, PF14659, MF_02055, TIGR02224, COG4974	NA	NA
UHGV-0045054_2	PHROG	phrog_16129	excisionase	integration and excision
UHGV-0045054_2	UniRef90	UniRef90_A0A412RR26	HTH luxR-type domain-containing protein	NA
UHGV-0045054_2	eggNOG-mapper	411489.CLOL250_01459	Excisionase from transposon Tn916	NA
UHGV-0045054_2	Pfam	PF00196	Bacterial regulatory proteins, luxR family	GerE
UHGV-0045054_2	Pfam	PF09035	Excisionase from transposon Tn916	Tn916-Xis
UHGV-0045054_2	NCBIFam	TIGR01764.1	excisionase family DNA-binding protein	NA
UHGV-0045054_2	Structural annotation	PF09035, PF00196, MF_00674, NF033787, NF008895, COG2771	NA	NA
UHGV-0045054_3	Structural annotation	PF09889, MF_00649	NA	NA
UHGV-0045054_5	Structural annotation	COG4446	NA	NA
UHGV-0045054_6	PHROG	phrog_8684	NA	unknown function
UHGV-0045054_6	UniRef90	UniRef90_UPI001D033076	YopX family protein	NA
UHGV-0045054_6	eggNOG-mapper	411470.RUMGNA_02199	NA	NA
UHGV-0045054_6	Pfam	PF09643	YopX protein	YopX
UHGV-0045054_6	NCBIFam	TIGR01671.1	phage conserved hypothetical protein TIGR01671	NA
UHGV-0045054_6	Structural annotation	PF09643, TIGR01671	NA	NA
UHGV-0045054_7	eggNOG-mapper	665956.HMPREF1032_03084	NA	NA
UHGV-0045054_9	eggNOG-mapper	397288.C806_00098	NA	NA
UHGV-0045054_10	PHROG	phrog_22292	NA	unknown function
UHGV-0045054_15	PHROG	phrog_9804	NA	unknown function
UHGV-0045054_15	UniRef90	UniRef90_A0A412RQW3	Inhibitor_G39P domain-containing protein	NA
UHGV-0045054_15	eggNOG-mapper	1410650.JHWL01000003_gene2847	Loader and inhibitor of phage G40P	NA
UHGV-0045054_15	Pfam	PF11417	Loader and inhibitor of phage G40P	Inhibitor_G39P
UHGV-0045054_15	Structural annotation	PF11417	NA	NA
UHGV-0045054_16	PHROG	phrog_5708	DnaD-like helicase loader	DNA, RNA and nucleotide metabolism
UHGV-0045054_16	UniRef90	UniRef90_UPI001BB8B78A	Phage replication initiation protein	NA
UHGV-0045054_16	eggNOG-mapper	1415774.U728_867	DnaD domain protein	NA
UHGV-0045054_16	COG	COG3935	DNA replication protein DnaD	NA
UHGV-0045054_16	Structural annotation	PF09681, TIGR01714	NA	NA
UHGV-0045054_17	Structural annotation	PF17388	NA	NA
UHGV-0045054_18	UniRef90	UniRef90_A0A1Y4R9D2	Radical SAM protein	NA
UHGV-0045054_18	COG	COG0535	Radical SAM superfamily maturase, SkfB/NifB/PqqE family	NA
UHGV-0045054_18	Structural annotation	PF04055, MF_01225_A, TIGR04303, COG0535	NA	NA
UHGV-0045054_19	PHROG	phrog_19106	NA	unknown function
UHGV-0045054_19	UniRef90	UniRef90_A0A412RQV5	GIY-YIG nuclease family protein	NA
UHGV-0045054_19	eggNOG-mapper	658655.HMPREF0988_00875	NA	NA
UHGV-0045054_19	Structural annotation	TIGR01453	NA	NA
UHGV-0045054_21	KOfam	K03111	ssb; single-strand DNA-binding protein	NA
UHGV-0045054_21	PHROG	phrog_44	single strand DNA binding protein	DNA, RNA and nucleotide metabolism
UHGV-0045054_21	UniRef90	UniRef90_A0A412RR48	Single-stranded DNA-binding protein	NA
UHGV-0045054_21	eggNOG-mapper	397290.C810_01495	Single-strand binding protein family	NA
UHGV-0045054_21	Pfam	PF00436	Single-strand binding protein family	SSB
UHGV-0045054_21	NCBIFam	TIGR00621.2	single-stranded DNA-binding protein	NA
UHGV-0045054_21	COG	COG0629	Single-stranded DNA-binding protein	NA
UHGV-0045054_21	HAMAP	MF_00984	Single-stranded DNA-binding protein	NA
UHGV-0045054_21	Structural annotation	PF00436, MF_00984, NF005580, COG0629	NA	NA
UHGV-0045054_22	PHROG	phrog_20891	HNH endonuclease	DNA, RNA and nucleotide metabolism
UHGV-0045054_22	UniRef90	UniRef90_A0A8J6J193	HNH endonuclease	NA
UHGV-0045054_22	eggNOG-mapper	864702.OsccyDRAFT_0645	HNH endonuclease	NA
UHGV-0045054_22	Pfam	PF13392	HNH endonuclease	HNH_3
UHGV-0045054_23	PHROG	phrog_392	metal-dependent hydrolase	other
UHGV-0045054_23	UniRef90	UniRef90_A0A412RQX2	MBL fold metallo-hydrolase	NA
UHGV-0045054_23	eggNOG-mapper	1232453.BAIF02000057_gene1138	May be involved in the transport of PQQ or its precursor to the periplasm	NA
UHGV-0045054_23	COG	COG1235	Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase	NA
UHGV-0045054_23	Structural annotation	PF02112, MF_00457, NF041851, COG2220	NA	NA
UHGV-0045054_24	PHROG	phrog_392	metal-dependent hydrolase	other
UHGV-0045054_24	UniRef90	UniRef90_A0A416JIG7	MBL fold metallo-hydrolase	NA
UHGV-0045054_24	eggNOG-mapper	443254.Marpi_0302	May be involved in the transport of PQQ or its precursor to the periplasm	NA
UHGV-0045054_24	COG	COG1235	Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase	NA
UHGV-0045054_25	PHROG	phrog_59	HNH endonuclease	DNA, RNA and nucleotide metabolism
UHGV-0045054_25	UniRef90	UniRef90_C0CR26	HNHc domain-containing protein	NA
UHGV-0045054_25	eggNOG-mapper	1500386.A0A060AFF3_9CAUD	HNH endonuclease	NA
UHGV-0045054_25	PADLOC	HEase_00016	homing endonuclease	RM
UHGV-0045054_25	Pfam	PF07463	NUMOD4 motif	NUMOD4
UHGV-0045054_25	Pfam	PF13392	HNH endonuclease	HNH_3
UHGV-0045054_25	Structural annotation	PF13392, PF07463	NA	NA
UHGV-0045054_27	PHROG	phrog_25456	NA	unknown function
UHGV-0045054_28	KOfam	K07455	recT; recombination protein RecT	NA
UHGV-0045054_28	PHROG	phrog_148	RecT-like ssDNA annealing protein	DNA, RNA and nucleotide metabolism
UHGV-0045054_28	UniRef90	UniRef90_A0A317UEK3	Recombinase RecT	NA
UHGV-0045054_28	eggNOG-mapper	1298920.KI911353_gene2727	RecT family	NA
UHGV-0045054_28	Pfam	PF03837	RecT family	RecT
UHGV-0045054_28	NCBIFam	TIGR00616.1	recombinase, phage RecT family	NA
UHGV-0045054_28	COG	COG3723	Recombinational DNA repair protein RecT	NA
UHGV-0045054_28	Structural annotation	PF03837, NF007351, COG3723	NA	NA
UHGV-0045054_29	PHROG	phrog_4433	NA	unknown function
UHGV-0045054_29	eggNOG-mapper	886882.PPSC2_p0363	regulation of DNA-templated transcription, elongation	NA
UHGV-0045054_29	COG	COG5164	Transcription elongation factor SPT5	NA
UHGV-0045054_29	Structural annotation	NF007410	NA	NA
UHGV-0045054_33	KOfam	K19171	dndD; DNA sulfur modification protein DndD	NA
UHGV-0045054_33	PHROG	phrog_77	SbcC-like subunit of palindrome specific endonuclease	DNA, RNA and nucleotide metabolism
UHGV-0045054_33	UniRef90	UniRef90_A0A412RQV0	AAA_23 domain-containing protein	NA
UHGV-0045054_33	eggNOG-mapper	397290.C810_01461	nuclear chromosome segregation	NA
UHGV-0045054_33	COG	COG1196	Chromosome segregation ATPase Smc	NA
UHGV-0045054_33	Structural annotation	PF02463, MF_00449, NF041034, COG0419	NA	NA
UHGV-0045054_36	UniRef90	UniRef90_UPI0013EC7599	G5 domain-containing protein	NA
UHGV-0045054_36	eggNOG-mapper	742765.HMPREF9457_03017	peptidase	NA
UHGV-0045054_36	COG	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	NA
UHGV-0045054_37	PHROG	phrog_463	anti-repressor	transcription regulation
UHGV-0045054_37	UniRef90	UniRef90_A0A412RQX1	Phage repressor protein	NA
UHGV-0045054_37	eggNOG-mapper	596329.HMPREF0631_1352	BRO family, N-terminal domain protein	NA
UHGV-0045054_37	Pfam	PF02498	BRO family, N-terminal domain	Bro-N
UHGV-0045054_37	Pfam	PF10552	ORF6C domain	ORF6C
UHGV-0045054_37	COG	COG3617	Prophage antirepressor	NA
UHGV-0045054_37	Structural annotation	PF10552, PF02498, TIGR02681, COG3617	NA	NA
UHGV-0045054_38	COG	COG0386	Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides	NA
UHGV-0045054_41	PHROG	phrog_8	transcriptional regulator	transcription regulation
UHGV-0045054_41	UniRef90	UniRef90_UPI001C012A29	helix-turn-helix domain-containing protein	NA
UHGV-0045054_41	eggNOG-mapper	1304866.K413DRAFT_0834	PFAM helix-turn-helix domain protein	NA
UHGV-0045054_41	Pfam	PF12844	Helix-turn-helix domain	HTH_19
UHGV-0045054_41	COG	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	NA
UHGV-0045054_41	Structural annotation	PF01381, NF041951, COG1396	NA	NA
UHGV-0045054_42	KOfam	K22300	dicA; HTH-type transcriptional regulator, cell division transcriptional repressor	NA
UHGV-0045054_42	PHROG	phrog_8	transcriptional regulator	transcription regulation
UHGV-0045054_42	UniRef90	UniRef90_A0A412RR31	Helix-turn-helix domain-containing protein	NA
UHGV-0045054_42	eggNOG-mapper	1232449.BAHV02000016_gene1846	Peptidase S24-like	NA
UHGV-0045054_42	Pfam	PF01381	Helix-turn-helix	HTH_3
UHGV-0045054_42	COG	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	NA
UHGV-0045054_42	Structural annotation	PF12844, NF041951, COG1476	NA	NA
UHGV-0045054_43	PHROG	phrog_3845	NA	unknown function
UHGV-0045054_43	eggNOG-mapper	1262449.CP6013_3208	NA	NA
UHGV-0045054_45	eggNOG-mapper	1280676.AUJO01000001_gene2313	NA	NA
UHGV-0045054_45	Pfam	PF11611	NA	DUF4352
UHGV-0045054_45	Structural annotation	PF11611, MF_00791, NF003967, COG2967	NA	NA
UHGV-0045054_46	UniRef90	UniRef90_A0A349YRM6	XkdX family protein	NA
UHGV-0045054_46	eggNOG-mapper	411468.CLOSCI_01507	Phage uncharacterised protein (Phage_XkdX)	NA
UHGV-0045054_46	Pfam	PF09693	Phage uncharacterised protein (Phage_XkdX)	Phage_XkdX
UHGV-0045054_46	Structural annotation	PF09693, TIGR01669	NA	NA
UHGV-0045054_47	PHROG	phrog_20201	NA	unknown function
UHGV-0045054_48	PHROG	phrog_5302	tail protein	tail
UHGV-0045054_48	UniRef90	UniRef90_A0A345BPB9	Lectin	NA
UHGV-0045054_48	eggNOG-mapper	428125.CLOLEP_01426	NA	NA
UHGV-0045054_48	Structural annotation	COG1262	NA	NA
UHGV-0045054_49	eggNOG-mapper	1121866.AUGK01000003_gene1445	NA	NA
UHGV-0045054_49	Pfam	PF11839	Alanine-zipper, major outer membrane lipoprotein	Alanine_zipper
UHGV-0045054_50	PHROG	phrog_6616	tail protein	tail
UHGV-0045054_50	UniRef90	UniRef90_A0A412RR71	Tail fiber domain-containing protein	NA
UHGV-0045054_50	eggNOG-mapper	476272.RUMHYD_01992	NA	NA
UHGV-0045054_50	Pfam	PF13884	Chaperone of endosialidase	Peptidase_S74
UHGV-0045054_50	Structural annotation	PF05113, NF033848, COG3500	NA	NA
UHGV-0045054_51	PHROG	phrog_1194	NA	unknown function
UHGV-0045054_51	eggNOG-mapper	997830.HMPREF1124_0608	NA	NA
UHGV-0045054_51	Pfam	PF20458	NA	DUF6711
UHGV-0045054_51	Structural annotation	PF20458, TIGR02126, COG3499	NA	NA
UHGV-0045054_52	PHROG	phrog_1535	tail length tape measure protein	tail
UHGV-0045054_52	eggNOG-mapper	397290.C810_01419	Transglycosylase SLT domain	NA
UHGV-0045054_52	COG	COG1280	Threonine/homoserine/homoserine lactone efflux protein	NA
UHGV-0045054_53	PHROG	phrog_314	homing endonuclease	DNA, RNA and nucleotide metabolism
UHGV-0045054_53	UniRef90	UniRef90_UPI001C0FF971	GIY-YIG nuclease family protein	NA
UHGV-0045054_53	eggNOG-mapper	1380384.JADN01000003_gene632	Intron encoded nuclease repeat motif	NA
UHGV-0045054_53	Pfam	PF01541	GIY-YIG catalytic domain	GIY-YIG
UHGV-0045054_53	Pfam	PF07453	NUMOD1 domain	NUMOD1
UHGV-0045054_53	NCBIFam	TIGR01453.1	group I intron endonuclease	NA
UHGV-0045054_53	Structural annotation	PF07453, PF19835, PF04936, TIGR01453	NA	NA
UHGV-0045054_54	PHROG	phrog_1535	tail length tape measure protein	tail
UHGV-0045054_54	UniRef90	UniRef90_A0A173UI54	Phage-related protein	NA
UHGV-0045054_54	eggNOG-mapper	1408437.JNJN01000010_gene1238	domain protein	NA
UHGV-0045054_54	COG	COG1511	NA	NA
UHGV-0045054_55	KOfam	K07273	acm; lysozyme	NA
UHGV-0045054_55	PHROG	phrog_291	endolysin	lysis
UHGV-0045054_55	UniRef90	UniRef90_A0A174GRH8	Autolytic lysozyme	NA
UHGV-0045054_55	eggNOG-mapper	1235800.C819_00458	Glycosyl hydrolases family 25	NA
UHGV-0045054_55	Pfam	PF01183	Glycosyl hydrolases family 25	Glyco_hydro_25
UHGV-0045054_55	COG	COG3757	Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family	NA
UHGV-0045054_55	Structural annotation	PF01183, PF01471, MF_01672, COG3757, COG3409	NA	NA
UHGV-0045054_58	UniRef90	UniRef90_R7BGF5	Phage tail protein	NA
UHGV-0045054_58	Structural annotation	PF16463, TIGR02126, COG5437	NA	NA
UHGV-0045054_59	Structural annotation	PF05657	NA	NA
UHGV-0045054_60	eggNOG-mapper	1232453.BAIF02000058_gene1631	NA	NA
UHGV-0045054_60	AcrCatalog	cluster_24841	NA	NA
UHGV-0045054_61	eggNOG-mapper	1298920.KI911353_gene2656	NA	NA
UHGV-0045054_61	Structural annotation	PF07405, TIGR01563, COG5614	NA	NA
UHGV-0045054_62	PHROG	phrog_1129	holin	lysis
UHGV-0045054_62	UniRef90	UniRef90_A0A412RR82	Enolase	NA
UHGV-0045054_62	eggNOG-mapper	411461.DORFOR_00721	NA	NA
UHGV-0045054_62	Pfam	PF16079	Phage holin family Hol44, in holin superfamily V	Phage_holin_5_2
UHGV-0045054_62	Structural annotation	PF06946	NA	NA
UHGV-0045054_63	PHROG	phrog_4105	NA	unknown function
UHGV-0045054_63	eggNOG-mapper	411459.RUMOBE_00911	NA	NA
UHGV-0045054_64	eggNOG-mapper	397290.C810_01402	NA	NA
UHGV-0045054_65	UniRef90	UniRef90_A0A8D9UIY7	Rho termination factor	NA
UHGV-0045054_65	Structural annotation	PF21169	NA	NA
UHGV-0045054_66	PHROG	phrog_29	major head protein	head and packaging
UHGV-0045054_66	UniRef90	UniRef90_A0A412RQU1	Major capsid protein	NA
UHGV-0045054_66	eggNOG-mapper	1296659.S5MNB6_9CAUD	Phage major capsid protein E	NA
UHGV-0045054_66	Pfam	PF03864	Phage major capsid protein E	Phage_cap_E
UHGV-0045054_66	Structural annotation	PF03864, MF_04133, NF041162, COG4653	NA	NA
UHGV-0045054_67	PHROG	phrog_909	major head protein	head and packaging
UHGV-0045054_67	UniRef90	UniRef90_R7BGI8	Phage major capsid protein	NA
UHGV-0045054_67	eggNOG-mapper	1078085.HMPREF1210_01145	NA	NA
UHGV-0045054_69	PHROG	phrog_2662	portal protein	head and packaging
UHGV-0045054_69	UniRef90	UniRef90_A0A412RR50	Phage_Mu_F domain-containing protein	NA
UHGV-0045054_69	eggNOG-mapper	1207076.ALAT01000105_gene1902	head morphogenesis protein, SPP1	NA
UHGV-0045054_69	Pfam	PF04233	Phage Mu protein F like protein	Phage_Mu_F
UHGV-0045054_69	COG	COG2369	NA	NA
UHGV-0045054_69	Structural annotation	PF04233, TIGR01641	NA	NA
UHGV-0045054_70	PHROG	phrog_64	portal protein	head and packaging
UHGV-0045054_70	UniRef90	UniRef90_A0A412RQZ0	Phage portal protein	NA
UHGV-0045054_70	eggNOG-mapper	1232453.BAIF02000058_gene1625	Phage portal protein, SPP1 Gp6-like	NA
UHGV-0045054_70	Pfam	PF05133	Phage portal protein, SPP1 Gp6-like	Phage_prot_Gp6
UHGV-0045054_70	Structural annotation	PF05133, MF_04120, TIGR01538, COG5511	NA	NA
UHGV-0045054_71	UniRef90	UniRef90_A0A8D9UIR9	RimK-related lysine biosynthesis protein	NA
UHGV-0045054_72	PHROG	phrog_36	transcriptional regulator	transcription regulation
UHGV-0045054_72	UniRef90	UniRef90_A0A6N7XL46	Sigma-70 family RNA polymerase sigma factor	NA
UHGV-0045054_72	eggNOG-mapper	1123288.SOV_6c01520	sigma factor activity	NA
UHGV-0045054_72	Pfam	PF07374	NA	DUF1492
UHGV-0045054_72	COG	COG1191	DNA-directed RNA polymerase specialized sigma subunit	NA
UHGV-0045054_72	Structural annotation	PF07374, MF_00674, NF008895, COG1191	NA	NA
UHGV-0045054_73	PHROG	phrog_38	terminase large subunit	head and packaging
UHGV-0045054_73	UniRef90	UniRef90_A0A8D9UIV2	Terminase	NA
UHGV-0045054_73	eggNOG-mapper	397290.C810_01390	chromosome segregation	NA
UHGV-0045054_73	COG	COG5410	NA	NA
UHGV-0045054_73	Structural annotation	PF17289, PF04466, MF_04147, NF033889, COG5410, COG5362	NA	NA
UHGV-0045054_74	PHROG	phrog_2316	NA	unknown function
UHGV-0045054_74	UniRef90	UniRef90_A0A3E4YBW5	NA	NA
UHGV-0045054_74	eggNOG-mapper	1280676.AUJO01000024_gene3262	NA	NA
UHGV-0045054_74	Structural annotation	PF16475, MF_00436, NF033216	NA	NA
UHGV-0045054_77	PHROG	phrog_25639	NA	unknown function
UHGV-0045054_77	eggNOG-mapper	585501.HMPREF6123_0841	NA	NA
UHGV-0045054_78	UniRef90	UniRef90_A0A8D9PGN8	Acetyl-coA carboxylase zinc finger domain protein	NA
UHGV-0045054_80	PHROG	phrog_28328	NA	unknown function
UHGV-0045054_82	UniRef90	UniRef90_A0A8D9PGW1	HTH psq-type domain-containing protein	NA
UHGV-0045054_82	Structural annotation	PF05225, COG2886	NA	NA
UHGV-0045054_83	PHROG	phrog_22444	NA	unknown function
UHGV-0045054_83	UniRef90	UniRef90_UPI001CC2634F	helix-turn-helix domain-containing protein	NA
UHGV-0045054_83	eggNOG-mapper	1121422.AUMW01000042_gene1260	DnaD domain protein	NA
UHGV-0045054_83	COG	COG3935	DNA replication protein DnaD	NA
UHGV-0045054_83	Structural annotation	PF05584, NF000243, COG0640	NA	NA
UHGV-0045054_86	PHROG	phrog_236	nucleotide kinase	other
UHGV-0045054_86	UniRef90	UniRef90_A0A412RQV8	NA	NA
UHGV-0045054_86	eggNOG-mapper	1236504.HMPREF2132_11120	NA	NA
UHGV-0045054_86	Pfam	PF11753	NA	DUF3310
UHGV-0045054_86	Structural annotation	PF11753	NA	NA
UHGV-0045054_87	eggNOG-mapper	658655.HMPREF0988_00895	NA	NA