| UHGV-1262590_9 | PHROG | phrog_8470 | NA | unknown function |
| UHGV-1262590_9 | eggNOG-mapper | 1410625.JHWK01000005_gene1301 | PcfJ-like protein | NA |
| UHGV-1262590_9 | Pfam | PF14284 | PcfJ-like protein | PcfJ |
| UHGV-1262590_9 | Structural annotation | PF14284 | NA | NA |
| UHGV-1262590_10 | Structural annotation | PF11019, MF_01022, NF003937, COG4502 | NA | NA |
| UHGV-1262590_12 | PHROG | phrog_20187 | NA | unknown function |
| UHGV-1262590_12 | Structural annotation | PF21762, MF_00045, NF006316, COG0847 | NA | NA |
| UHGV-1262590_19 | Structural annotation | PF13046 | NA | NA |
| UHGV-1262590_22 | PHROG | phrog_5767 | sigma factor | transcription regulation |
| UHGV-1262590_22 | UniRef90 | UniRef90_A0A345BPU6 | HTH DNA binding domain protein | NA |
| UHGV-1262590_22 | eggNOG-mapper | 1123239.KB898628_gene3218 | NA | NA |
| UHGV-1262590_23 | PHROG | phrog_3314 | NA | unknown function |
| UHGV-1262590_23 | eggNOG-mapper | 1308863.U5J9N3_9CAUD | NA | NA |
| UHGV-1262590_24 | PHROG | phrog_15503 | NA | unknown function |
| UHGV-1262590_24 | UniRef90 | UniRef90_A0A0H3V0N0 | Putative terminase large subunit | NA |
| UHGV-1262590_24 | eggNOG-mapper | 574375.BAGA_05930 | Terminase-like family | NA |
| UHGV-1262590_24 | COG | COG4373 | Mu-like prophage FluMu protein gp28 | NA |
| UHGV-1262590_25 | PHROG | phrog_24618 | NA | unknown function |
| UHGV-1262590_25 | UniRef90 | UniRef90_A0A7C6N8D2 | DNA-packaging protein | NA |
| UHGV-1262590_25 | eggNOG-mapper | 1308863.U5J9B2_9CAUD | NA | NA |
| UHGV-1262590_26 | PHROG | phrog_2739 | portal protein | head and packaging |
| UHGV-1262590_26 | UniRef90 | UniRef90_A0A345BPV2 | Putative portal protein | NA |
| UHGV-1262590_26 | eggNOG-mapper | 665956.HMPREF1032_03237 | NA | NA |
| UHGV-1262590_26 | Structural annotation | PF05133, MF_04135, TIGR01537, COG4695 | NA | NA |
| UHGV-1262590_27 | PHROG | phrog_3313 | NA | unknown function |
| UHGV-1262590_27 | UniRef90 | UniRef90_A0A843FJ52 | HALZ domain-containing protein | NA |
| UHGV-1262590_27 | eggNOG-mapper | 1304866.K413DRAFT_4735 | NA | NA |
| UHGV-1262590_27 | Structural annotation | PF09979, TIGR01543, COG3566 | NA | NA |
| UHGV-1262590_29 | PHROG | phrog_4088 | NA | unknown function |
| UHGV-1262590_29 | eggNOG-mapper | 1541960.KQ78_01850 | NA | NA |
| UHGV-1262590_29 | Structural annotation | PF05065, MF_04119, TIGR01554, COG4653 | NA | NA |
| UHGV-1262590_30 | PHROG | phrog_30998 | NA | unknown function |
| UHGV-1262590_31 | PHROG | phrog_3853 | NA | unknown function |
| UHGV-1262590_32 | PHROG | phrog_29637 | NA | unknown function |
| UHGV-1262590_33 | PHROG | phrog_31155 | NA | unknown function |
| UHGV-1262590_33 | Structural annotation | PF19408, PF11649, NF041894, COG5614 | NA | NA |
| UHGV-1262590_34 | PHROG | phrog_6123 | virion structural protein | head and packaging |
| UHGV-1262590_34 | Structural annotation | PF06141 | NA | NA |
| UHGV-1262590_35 | PHROG | phrog_4051 | NA | unknown function |
| UHGV-1262590_36 | PHROG | phrog_2729 | virion structural protein | head and packaging |
| UHGV-1262590_36 | eggNOG-mapper | 1163671.JAGI01000002_gene1222 | NA | NA |
| UHGV-1262590_40 | PHROG | phrog_4211 | tail length tape measure protein | tail |
| UHGV-1262590_40 | eggNOG-mapper | 720555.BATR1942_08060 | nuclear chromosome segregation | NA |
| UHGV-1262590_40 | Pfam | PF10145 | Phage-related minor tail protein | PhageMin_Tail |
| UHGV-1262590_40 | NCBIFam | TIGR01760.1 | phage tail tape measure protein | NA |
| UHGV-1262590_40 | COG | COG1196 | Chromosome segregation ATPase Smc | NA |
| UHGV-1262590_43 | Structural annotation | PF05939, PF12245, TIGR01633, COG3499 | NA | NA |
| UHGV-1262590_44 | PHROG | phrog_32343 | NA | unknown function |
| UHGV-1262590_44 | UniRef90 | UniRef90_A0A345BPW9 | Putative flagellin-like protein | NA |
| UHGV-1262590_44 | Structural annotation | PF05113, NF033848, COG4379 | NA | NA |
| UHGV-1262590_48 | eggNOG-mapper | 537007.BLAHAN_05239 | cellulose 1,4-beta-cellobiosidase activity | NA |
| UHGV-1262590_48 | COG | COG5301 | Phage-related tail fiber protein | NA |
| UHGV-1262590_49 | Structural annotation | MF_01186 | NA | NA |
| UHGV-1262590_50 | PHROG | phrog_14959 | NA | unknown function |
| UHGV-1262590_52 | eggNOG-mapper | 1304866.K413DRAFT_4770 | PFAM Formylglycine-generating sulfatase enzyme | NA |
| UHGV-1262590_52 | COG | COG1262 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain | NA |
| UHGV-1262590_52 | Structural annotation | PF10651, NF010681 | NA | NA |
| UHGV-1262590_53 | eggNOG-mapper | 1304866.K413DRAFT_4770 | PFAM Formylglycine-generating sulfatase enzyme | NA |
| UHGV-1262590_53 | COG | COG1262 | Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain | NA |
| UHGV-1262590_55 | PHROG | phrog_24267 | NA | unknown function |
| UHGV-1262590_55 | eggNOG-mapper | 742742.HMPREF9452_00376 | tail collar domain protein | NA |
| UHGV-1262590_55 | COG | COG4675 | Phage tail collar domain | NA |
| UHGV-1262590_56 | Structural annotation | PF13895, MF_04116, TIGR04488, COG3291 | NA | NA |
| UHGV-1262590_57 | PHROG | phrog_13712 | holin | lysis |
| UHGV-1262590_57 | eggNOG-mapper | 1227352.C173_31866 | NA | NA |
| UHGV-1262590_58 | eggNOG-mapper | 658655.HMPREF0988_00918 | NA | NA |
| UHGV-1262590_59 | PHROG | phrog_16490 | NA | unknown function |
| UHGV-1262590_59 | eggNOG-mapper | 658655.HMPREF0988_00917 | NA | NA |
| UHGV-1262590_60 | PHROG | phrog_20016 | NA | unknown function |
| UHGV-1262590_60 | UniRef90 | UniRef90_A0A345BPX4 | Carbohydrate binding domain/collagen triple helix repeat protein | NA |
| UHGV-1262590_60 | eggNOG-mapper | 1226322.HMPREF1545_00077 | NA | NA |
| UHGV-1262590_60 | Structural annotation | PF18573, NF033147 | NA | NA |
| UHGV-1262590_61 | eggNOG-mapper | 658655.HMPREF0988_00915 | NA | NA |
| UHGV-1262590_63 | PHROG | phrog_827 | Holliday junction resolvase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_63 | UniRef90 | UniRef90_A0A7K3Z7M4 | Crossover junction endodeoxyribonuclease RuvC | NA |
| UHGV-1262590_63 | eggNOG-mapper | 608538.HTH_0531 | Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group | NA |
| UHGV-1262590_63 | COG | COG0817 | Holliday junction resolvasome RuvABC endonuclease subunit RuvC | NA |
| UHGV-1262590_63 | Structural annotation | PF07066, MF_00034, NF000711, COG0817 | NA | NA |
| UHGV-1262590_64 | KOfam | K01520 | dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] | NA |
| UHGV-1262590_64 | PHROG | phrog_135 | dUTPase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_64 | UniRef90 | UniRef90_A0A843FKH7 | dUTPase domain-containing protein (Fragment) | NA |
| UHGV-1262590_64 | eggNOG-mapper | 1203076.CAKF01000036_gene981 | dUTP diphosphatase | NA |
| UHGV-1262590_64 | Pfam | PF00692 | dUTPase | dUTPase |
| UHGV-1262590_64 | COG | COG0756 | dUTP pyrophosphatase (dUTPase) | NA |
| UHGV-1262590_64 | Structural annotation | PF00692, MF_00116, NF010561, COG0756 | NA | NA |
| UHGV-1262590_65 | Structural annotation | PF10750, MF_01122, TIGR00285, COG1581 | NA | NA |
| UHGV-1262590_66 | Structural annotation | PF04937, MF_00034, NF001026, COG0816 | NA | NA |
| UHGV-1262590_67 | Structural annotation | PF20010 | NA | NA |
| UHGV-1262590_68 | KOfam | K02824 | uraA, pyrP; uracil permease | NA |
| UHGV-1262590_68 | PHROG | phrog_20031 | NA | unknown function |
| UHGV-1262590_68 | UniRef90 | UniRef90_A0A8E8EBY0 | NCS2 family nucleobase:cation symporter | NA |
| UHGV-1262590_68 | eggNOG-mapper | 877415.JNJQ01000002_gene2303 | NA | NA |
| UHGV-1262590_68 | Pfam | PF00860 | Permease family | Xan_ur_permease |
| UHGV-1262590_68 | COG | COG2233 | Xanthine/uracil permease | NA |
| UHGV-1262590_68 | Structural annotation | PF00860, NF007995, COG2233 | NA | NA |
| UHGV-1262590_69 | PHROG | phrog_1817 | nucleoside 2-deoxyribosyltransferase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_69 | UniRef90 | UniRef90_A0A843GYA4 | Nucleoside 2-deoxyribosyltransferase | NA |
| UHGV-1262590_69 | eggNOG-mapper | 1145276.T479_13235 | Nucleoside 2-deoxyribosyltransferase | NA |
| UHGV-1262590_69 | Pfam | PF05014 | Nucleoside 2-deoxyribosyltransferase | Nuc_deoxyrib_tr |
| UHGV-1262590_69 | COG | COG3613 | Nucleoside 2-deoxyribosyltransferase | NA |
| UHGV-1262590_70 | eggNOG-mapper | 1356854.N007_12155 | Belongs to the LOG family | NA |
| UHGV-1262590_70 | COG | COG1611 | Nucleotide monophosphate nucleosidase PpnN/YdgH, Lonely Guy (LOG) family | NA |
| UHGV-1262590_70 | Structural annotation | PF14359, MF_03036, TIGR03646, COG3613 | NA | NA |
| UHGV-1262590_71 | KOfam | K04068 | nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] | NA |
| UHGV-1262590_71 | PHROG | phrog_626 | anaerobic ribonucleotide reductase small subunit | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_71 | UniRef90 | UniRef90_A0A843FG79 | Anaerobic ribonucleoside-triphosphate reductase activating protein | NA |
| UHGV-1262590_71 | eggNOG-mapper | 1401067.HMPREF0872_03965 | Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine | NA |
| UHGV-1262590_71 | Pfam | PF13353 | 4Fe-4S single cluster domain | Fer4_12 |
| UHGV-1262590_71 | NCBIFam | TIGR02491.1 | anaerobic ribonucleoside-triphosphate reductase activating protein | NA |
| UHGV-1262590_71 | COG | COG0602 | Organic radical activating enzyme NrdG/QueE | NA |
| UHGV-1262590_71 | Structural annotation | PF13353, MF_00917, TIGR02491, COG0602 | NA | NA |
| UHGV-1262590_72 | KOfam | K21636 | nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] | NA |
| UHGV-1262590_72 | PHROG | phrog_487 | NrdD-like anaerobic ribonucleotide reductase large subunit | moron, auxiliary metabolic gene and host takeover |
| UHGV-1262590_72 | UniRef90 | UniRef90_A0A3R6SNB8 | Anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-1262590_72 | eggNOG-mapper | 1304866.K413DRAFT_4593 | Ribonucleoside-triphosphate reductase | NA |
| UHGV-1262590_72 | Pfam | PF03477 | ATP cone domain | ATP-cone |
| UHGV-1262590_72 | Pfam | PF13597 | Anaerobic ribonucleoside-triphosphate reductase | NRDD |
| UHGV-1262590_72 | NCBIFam | TIGR02487.1 | anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-1262590_72 | COG | COG1328 | Anaerobic ribonucleoside-triphosphate reductase | NA |
| UHGV-1262590_72 | Structural annotation | PF13597, PF03477, MF_00440, NF005497, COG1328 | NA | NA |
| UHGV-1262590_74 | KOfam | K00942 | gmk, GUK1; guanylate kinase [EC:2.7.4.8] | NA |
| UHGV-1262590_74 | PHROG | phrog_1815 | guanylate kinase | other |
| UHGV-1262590_74 | UniRef90 | UniRef90_A0A843FCP8 | Guanylate kinase-like domain-containing protein | NA |
| UHGV-1262590_74 | eggNOG-mapper | 500632.CLONEX_03632 | NA | NA |
| UHGV-1262590_74 | Pfam | PF00625 | Guanylate kinase | Guanylate_kin |
| UHGV-1262590_74 | COG | COG0194 | Guanylate kinase | NA |
| UHGV-1262590_74 | Structural annotation | PF00625, MF_00328, TIGR03263, COG0194 | NA | NA |
| UHGV-1262590_75 | KOfam | K02337 | dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] | NA |
| UHGV-1262590_75 | PHROG | phrog_405 | DNA polymerase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_75 | UniRef90 | UniRef90_A0A858MXR6 | DNA-directed DNA polymerase | NA |
| UHGV-1262590_75 | eggNOG-mapper | 742735.HMPREF9467_00895 | DNA polymerase III alpha subunit | NA |
| UHGV-1262590_75 | Pfam | PF07733 | Bacterial DNA polymerase III alpha NTPase domain | DNA_pol3_alpha |
| UHGV-1262590_75 | Pfam | PF17657 | Bacterial DNA polymerase III alpha subunit finger domain | DNA_pol3_finger |
| UHGV-1262590_75 | Pfam | PF14579 | Helix-hairpin-helix motif | HHH_6 |
| UHGV-1262590_75 | COG | COG0587 | DNA polymerase III, alpha subunit | NA |
| UHGV-1262590_75 | Structural annotation | PF07733, PF02811, PF17657, PF14579, MF_01902, NF005617, COG0587 | NA | NA |
| UHGV-1262590_76 | KOfam | K03581 | recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] | NA |
| UHGV-1262590_76 | PHROG | phrog_325 | Dda-like helicase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_76 | UniRef90 | UniRef90_A0A345BPZ9 | ATP-dependent exoDNAse, alpha | NA |
| UHGV-1262590_76 | eggNOG-mapper | 1082931.KKY_297 | PIF1-like helicase | NA |
| UHGV-1262590_76 | Pfam | PF13538 | UvrD-like helicase C-terminal domain | UvrD_C_2 |
| UHGV-1262590_76 | COG | COG0507 | ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) | NA |
| UHGV-1262590_76 | Structural annotation | MF_03176, TIGR01447 | NA | NA |
| UHGV-1262590_78 | eggNOG-mapper | 1235800.C819_02712 | NA | NA |
| UHGV-1262590_78 | Pfam | PF18013 | Phage tail lysozyme | Phage_lysozyme2 |
| UHGV-1262590_78 | Structural annotation | PF18013, PF02185, NF001260 | NA | NA |
| UHGV-1262590_79 | KOfam | K07462 | recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] | NA |
| UHGV-1262590_79 | PHROG | phrog_2484 | RecJ-like ssDNA exonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_79 | UniRef90 | UniRef90_A0A843FU26 | DHH family phosphoesterase | NA |
| UHGV-1262590_79 | eggNOG-mapper | 224308.BSU20350 | Single-stranded-DNA-specific exonuclease RecJ | NA |
| UHGV-1262590_79 | Pfam | PF01368 | DHH family | DHH |
| UHGV-1262590_79 | Pfam | PF17768 | RecJ OB domain | RecJ_OB |
| UHGV-1262590_79 | COG | COG0608 | ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation | NA |
| UHGV-1262590_79 | Structural annotation | PF17768, PF02272, MF_00207, TIGR00644, COG0608 | NA | NA |
| UHGV-1262590_80 | KOfam | K02316 | dnaG; DNA primase [EC:2.7.7.101] | NA |
| UHGV-1262590_80 | PHROG | phrog_47 | DNA primase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_80 | UniRef90 | UniRef90_A0A345BPU0 | DNA primase | NA |
| UHGV-1262590_80 | eggNOG-mapper | 224308.BSU20360 | DNA primase activity | NA |
| UHGV-1262590_80 | COG | COG0358 | DNA primase (bacterial type) | NA |
| UHGV-1262590_80 | Structural annotation | PF01807, PF19898, MF_00974, NF006382, COG0358 | NA | NA |
| UHGV-1262590_82 | KOfam | K02314 | dnaB; replicative DNA helicase [EC:5.6.2.3] | NA |
| UHGV-1262590_82 | PHROG | phrog_19 | DnaB-like replicative helicase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_82 | UniRef90 | UniRef90_A0A843FNV1 | DNA helicase | NA |
| UHGV-1262590_82 | eggNOG-mapper | 537007.BLAHAN_05495 | DnaB-like helicase C terminal domain | NA |
| UHGV-1262590_82 | Pfam | PF03796 | DnaB-like helicase C terminal domain | DnaB_C |
| UHGV-1262590_82 | COG | COG0305 | Replicative DNA helicase | NA |
| UHGV-1262590_82 | Structural annotation | PF03796, PF00772, MF_04155, TIGR00665, COG0305 | NA | NA |
| UHGV-1262590_83 | PHROG | phrog_124 | Sak4-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_83 | UniRef90 | UniRef90_A0A843GMB3 | ATP-binding protein | NA |
| UHGV-1262590_83 | eggNOG-mapper | 1541960.KQ78_01919 | Belongs to the helicase family. UvrD subfamily | NA |
| UHGV-1262590_83 | Pfam | PF13479 | AAA domain | AAA_24 |
| UHGV-1262590_83 | COG | COG2887 | RecB family exonuclease | NA |
| UHGV-1262590_83 | Structural annotation | PF13479, MF_00350, TIGR01618, COG0468 | NA | NA |
| UHGV-1262590_84 | eggNOG-mapper | 10736.A0A1P8CX09_BPPHT | NA | NA |
| UHGV-1262590_84 | Structural annotation | PF00436, PF19649, MF_00984, NF004476, COG2965 | NA | NA |
| UHGV-1262590_85 | UniRef90 | UniRef90_A0A843FPF0 | Winged helix-turn-helix domain-containing protein | NA |
| UHGV-1262590_85 | Pfam | PF01978 | Sugar-specific transcriptional regulator TrmB | TrmB |
| UHGV-1262590_85 | Structural annotation | PF03444, MF_00732, TIGR02337, COG1321 | NA | NA |
| UHGV-1262590_86 | PHROG | phrog_7168 | homing endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_86 | UniRef90 | UniRef90_A0A843FP25 | GIY-YIG nuclease family protein | NA |
| UHGV-1262590_86 | eggNOG-mapper | 762660.E5EZ02_9CAUD | nucleic acid binding | NA |
| UHGV-1262590_86 | Pfam | PF01541 | GIY-YIG catalytic domain | GIY-YIG |
| UHGV-1262590_86 | NCBIFam | TIGR01453.1 | group I intron endonuclease | NA |
| UHGV-1262590_86 | Structural annotation | PF19835, TIGR01453 | NA | NA |
| UHGV-1262590_87 | Structural annotation | PF04182, MF_01909, NF040939, COG1675 | NA | NA |
| UHGV-1262590_89 | KOfam | K01972 | E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] | NA |
| UHGV-1262590_89 | PHROG | phrog_3869 | NAD-dependent DNA ligase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_89 | UniRef90 | UniRef90_A0A843FST5 | DNA ligase | NA |
| UHGV-1262590_89 | eggNOG-mapper | 411470.RUMGNA_00017 | DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA | NA |
| UHGV-1262590_89 | Pfam | PF01653 | NAD-dependent DNA ligase adenylation domain | DNA_ligase_aden |
| UHGV-1262590_89 | Pfam | PF03120 | NAD-dependent DNA ligase OB-fold domain | DNA_ligase_OB |
| UHGV-1262590_89 | Pfam | PF00533 | BRCA1 C Terminus (BRCT) domain | BRCT |
| UHGV-1262590_89 | NCBIFam | NF005932.1 | NAD-dependent DNA ligase LigA | NA |
| UHGV-1262590_89 | COG | COG0272 | NAD-dependent DNA ligase | NA |
| UHGV-1262590_89 | HAMAP | MF_01588 | DNA ligase [ligA] | NA |
| UHGV-1262590_89 | Structural annotation | PF01653, PF03120, PF00533, MF_01588, NF005932, COG0272 | NA | NA |
| UHGV-1262590_90 | KOfam | K02469 | gyrA; DNA gyrase subunit A [EC:5.6.2.2] | NA |
| UHGV-1262590_90 | PHROG | phrog_551 | DNA topoisomerase II | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_90 | UniRef90 | UniRef90_A0A3B9Z7C8 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-1262590_90 | eggNOG-mapper | 1541960.KQ78_01979 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-1262590_90 | Pfam | PF00521 | DNA gyrase/topoisomerase IV, subunit A | DNA_topoisoIV |
| UHGV-1262590_90 | Pfam | PF03989 | DNA gyrase C-terminal domain, beta-propeller | DNA_gyraseA_C |
| UHGV-1262590_90 | COG | COG0188 | DNA gyrase/topoisomerase IV, subunit A | NA |
| UHGV-1262590_90 | Structural annotation | PF00521, PF03989, MF_01897, NF004043, COG0188 | NA | NA |
| UHGV-1262590_91 | KOfam | K02470 | gyrB; DNA gyrase subunit B [EC:5.6.2.2] | NA |
| UHGV-1262590_91 | PHROG | phrog_543 | DNA topoisomerase II large subunit | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_91 | UniRef90 | UniRef90_A0A345BPY9 | DNA topoisomerase (ATP-hydrolyzing) | NA |
| UHGV-1262590_91 | eggNOG-mapper | 689781.AUJX01000045_gene2658 | A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | NA |
| UHGV-1262590_91 | Pfam | PF02518 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | HATPase_c |
| UHGV-1262590_91 | Pfam | PF00204 | DNA gyrase B | DNA_gyraseB |
| UHGV-1262590_91 | Pfam | PF01751 | Toprim domain | Toprim |
| UHGV-1262590_91 | Pfam | PF00986 | DNA gyrase B subunit, carboxyl terminus | DNA_gyraseB_C |
| UHGV-1262590_91 | COG | COG0187 | DNA gyrase/topoisomerase IV, subunit B | NA |
| UHGV-1262590_91 | Structural annotation | PF00204, MF_01898, TIGR01059, COG0187 | NA | NA |
| UHGV-1262590_92 | KOfam | K03469 | rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] | NA |
| UHGV-1262590_92 | PHROG | phrog_531 | Rnase H | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_92 | UniRef90 | UniRef90_A0A843FJ64 | Ribonuclease H | NA |
| UHGV-1262590_92 | eggNOG-mapper | 533240.CRC_02740 | Endonuclease that specifically degrades the RNA of RNA- DNA hybrids | NA |
| UHGV-1262590_92 | Pfam | PF00075 | RNase H | RNase_H |
| UHGV-1262590_92 | COG | COG0328 | Ribonuclease HI | NA |
| UHGV-1262590_92 | Structural annotation | PF00075, MF_00042, NF001236, COG0328 | NA | NA |
| UHGV-1262590_94 | KOfam | K01447 | xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] | NA |
| UHGV-1262590_94 | PHROG | phrog_20388 | endolysin | lysis |
| UHGV-1262590_94 | UniRef90 | UniRef90_A0A3D2HTX7 | N-acetylmuramoyl-L-alanine amidase domain-containing protein | NA |
| UHGV-1262590_94 | eggNOG-mapper | 1203606.HMPREF1526_01931 | N-acetylmuramoyl-L-alanine amidase | NA |
| UHGV-1262590_94 | Pfam | PF01510 | N-acetylmuramoyl-L-alanine amidase | Amidase_2 |
| UHGV-1262590_94 | COG | COG0860 | N-acetylmuramoyl-L-alanine amidase | NA |
| UHGV-1262590_94 | Structural annotation | PF01510, MF_04111, NF008758, COG5632 | NA | NA |
| UHGV-1262590_96 | KOfam | K07175 | phoH2; PhoH-like ATPase | NA |
| UHGV-1262590_96 | PHROG | phrog_2765 | PhoH-like phosphate starvation-inducible | other |
| UHGV-1262590_96 | UniRef90 | UniRef90_A0A1C5UCD2 | PhoH-like protein | NA |
| UHGV-1262590_96 | eggNOG-mapper | 1123252.ATZF01000010_gene420 | PIN domain | NA |
| UHGV-1262590_96 | Pfam | PF13638 | PIN domain | PIN_4 |
| UHGV-1262590_96 | Pfam | PF02562 | PhoH-like protein | PhoH |
| UHGV-1262590_96 | COG | COG1875 | Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains | NA |
| UHGV-1262590_96 | Structural annotation | PF02562, PF13638, PF09142, MF_00265, NF007827, NF009148, COG1875 | NA | NA |
| UHGV-1262590_98 | PHROG | phrog_547 | phosphoesterase | other |
| UHGV-1262590_98 | UniRef90 | UniRef90_A0A843GVP8 | Metallophosphoesterase family protein | NA |
| UHGV-1262590_98 | eggNOG-mapper | 1392491.JIAE01000001_gene1129 | Calcineurin-like phosphoesterase | NA |
| UHGV-1262590_98 | Pfam | PF12850 | Calcineurin-like phosphoesterase superfamily domain | Metallophos_2 |
| UHGV-1262590_98 | COG | COG4186 | NA | NA |
| UHGV-1262590_98 | Structural annotation | PF12850, MF_00575, NF006988, COG4186 | NA | NA |
| UHGV-1262590_99 | PHROG | phrog_6931 | NA | unknown function |
| UHGV-1262590_99 | UniRef90 | UniRef90_A0A843GTX6 | ATP-binding protein | NA |
| UHGV-1262590_99 | eggNOG-mapper | 1121382.JQKG01000013_gene451 | AAA domain | NA |
| UHGV-1262590_99 | Pfam | PF13671 | AAA domain | AAA_33 |
| UHGV-1262590_99 | COG | COG4639 | Predicted kinase | NA |
| UHGV-1262590_99 | Structural annotation | PF13671, MF_00065, TIGR03574, COG4088 | NA | NA |
| UHGV-1262590_101 | KOfam | K07074 | NA | NA |
| UHGV-1262590_101 | PHROG | phrog_388 | nucleotidyltransferase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_101 | UniRef90 | UniRef90_A0A843FSU3 | Nucleotidyltransferase domain-containing protein | NA |
| UHGV-1262590_101 | eggNOG-mapper | 1236973.JCM9157_1946 | Predicted nucleotidyltransferase | NA |
| UHGV-1262590_101 | Structural annotation | PF10127, NF000079, COG3541 | NA | NA |
| UHGV-1262590_111 | eggNOG-mapper | 1410626.JHXB01000018_gene1503 | NA | NA |
| UHGV-1262590_112 | PHROG | phrog_968 | RNA ligase | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_112 | UniRef90 | UniRef90_UPI00164D0579 | 2'-5' RNA ligase | NA |
| UHGV-1262590_112 | eggNOG-mapper | 247156.NFA_39550 | RNA ligase | NA |
| UHGV-1262590_112 | Structural annotation | PF21189, PF09414, MF_04150, TIGR02306, COG1423, COG0073 | NA | NA |
| UHGV-1262590_113 | PHROG | phrog_59 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1262590_113 | UniRef90 | UniRef90_UPI001E44C7C6 | HNH endonuclease | NA |
| UHGV-1262590_113 | eggNOG-mapper | 749413.E5DV63_9VIRU | HNH endonuclease | NA |
| UHGV-1262590_113 | PADLOC | HEase_00016 | homing endonuclease | RM |
| UHGV-1262590_113 | Pfam | PF07463 | NUMOD4 motif | NUMOD4 |
| UHGV-1262590_113 | Pfam | PF13392 | HNH endonuclease | HNH_3 |
| UHGV-1262590_116 | PHROG | phrog_6234 | host RecBCD nuclease inhibitor | moron, auxiliary metabolic gene and host takeover |
| UHGV-1262590_118 | KOfam | K07313 | pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16] | NA |
| UHGV-1262590_118 | PHROG | phrog_20114 | phosphoesterase | other |
| UHGV-1262590_118 | UniRef90 | UniRef90_R7DP57 | Metallophos domain-containing protein | NA |
| UHGV-1262590_118 | eggNOG-mapper | 500633.CLOHIR_00780 | phosphoprotein phosphatase activity | NA |
| UHGV-1262590_118 | Pfam | PF00149 | Calcineurin-like phosphoesterase | Metallophos |
| UHGV-1262590_118 | COG | COG0639 | Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family | NA |
| UHGV-1262590_118 | Structural annotation | PF12850, MF_01443, NF007425, COG0622 | NA | NA |
| UHGV-1262590_119 | PHROG | phrog_1040 | peptidase HslV family | other |
| UHGV-1262590_119 | UniRef90 | UniRef90_A0A8D9UHL8 | Proteasome subunit alpha type-2 | NA |
| UHGV-1262590_119 | eggNOG-mapper | 189425.PGRAT_19360 | Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine | NA |
| UHGV-1262590_119 | COG | COG0638 | 20S proteasome, alpha and beta subunits | NA |
| UHGV-1262590_119 | Structural annotation | PF00227, MF_00248, TIGR03692, COG5405 | NA | NA |
| UHGV-1262590_120 | PHROG | phrog_31229 | NA | unknown function |
| UHGV-1262590_120 | eggNOG-mapper | 562981.HMPREF0428_01861 | NA | NA |
| UHGV-1262590_124 | Structural annotation | PF13783, MF_01888, NF008362, COG5515 | NA | NA |
| UHGV-1262590_125 | PHROG | phrog_2598 | NA | unknown function |
| UHGV-1262590_125 | UniRef90 | UniRef90_E1KQC7 | HNH endonuclease domain protein | NA |
| UHGV-1262590_125 | eggNOG-mapper | 866771.HMPREF9296_1339 | NA | NA |
| UHGV-1262590_125 | PADLOC | REase_II_00020 | Type II restriction enzyme | RM |
| UHGV-1262590_125 | Pfam | PF03235 | NA | DUF262 |
| UHGV-1262590_125 | Pfam | PF01844 | HNH endonuclease | HNH |
| UHGV-1262590_125 | COG | COG1403 | 5-methylcytosine-specific restriction endonuclease McrA | NA |
| UHGV-1262590_125 | Structural annotation | PF14279, PF03235, MF_02015, TIGR00180, NF008448, COG1479, COG1403 | NA | NA |
| UHGV-1262590_126 | UniRef90 | UniRef90_A0A263HBM2 | Modification methylase | NA |
| UHGV-1262590_126 | eggNOG-mapper | 1541960.KQ78_02268 | Adenine-specific methyltransferase EcoRI | NA |
| UHGV-1262590_126 | PADLOC | MTase_II_00083 | Type II methyltransferase | RM |
| UHGV-1262590_126 | Pfam | PF13651 | Adenine-specific methyltransferase EcoRI | EcoRI_methylase |
| UHGV-1262590_126 | Structural annotation | PF13651, PF09202, TIGR02337 | NA | NA |
| UHGV-1262590_129 | Structural annotation | PF18414 | NA | NA |
| UHGV-1262590_131 | Structural annotation | PF08962 | NA | NA |
| UHGV-1262590_132 | Pfam | PF09479 | Listeria-Bacteroides repeat domain (List_Bact_rpt) | Flg_new |
| UHGV-1262590_132 | Pfam | PF18998 | Divergent InlB B-repeat domain | Flg_new_2 |
| UHGV-1262590_132 | NCBIFam | TIGR02543.1 | TIGR02543 family repeat protein | NA |
| UHGV-1262590_132 | COG | COG3209 | NA | NA |
| UHGV-1262590_134 | PHROG | phrog_19976 | tail assembly protein | tail |
| UHGV-1262590_134 | eggNOG-mapper | 1230469.M5AAF0_9CAUD | NA | NA |
| UHGV-1262590_134 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-1262590_135 | PHROG | phrog_33094 | NA | unknown function |
| UHGV-1262590_135 | COG | COG3064 | Membrane protein TolA involved in colicin uptake | NA |
| UHGV-1262590_136 | PHROG | phrog_35541 | NA | unknown function |
| UHGV-1262590_136 | UniRef90 | UniRef90_A0A3D6B2G4 | Mtd_N domain-containing protein | NA |
| UHGV-1262590_136 | eggNOG-mapper | 411470.RUMGNA_00120 | NA | NA |
| UHGV-1262590_136 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-1262590_136 | Structural annotation | PF18454 | NA | NA |
| UHGV-1262590_138 | PHROG | phrog_6049 | tail fiber protein | tail |
| UHGV-1262590_138 | UniRef90 | UniRef90_A0A8D9UHD2 | Hyaluroniase | NA |
| UHGV-1262590_138 | eggNOG-mapper | 357276.EL88_15700 | NA | NA |
| UHGV-1262590_138 | Pfam | PF18454 | Major tropism determinant N-terminal domain | Mtd_N |
| UHGV-1262590_138 | Structural annotation | PF18454, PF14262 | NA | NA |
| UHGV-1262590_139 | Structural annotation | PF20010 | NA | NA |
| UHGV-1262590_140 | KOfam | K22708 | tarS; poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase [EC:2.4.1.355] | NA |
| UHGV-1262590_140 | UniRef90 | UniRef90_A0A7X7B450 | Glycosyltransferase family 2 protein | NA |
| UHGV-1262590_140 | eggNOG-mapper | 386456.JQKN01000003_gene284 | glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC | NA |
| UHGV-1262590_140 | Pfam | PF00535 | Glycosyl transferase family 2 | Glycos_transf_2 |
| UHGV-1262590_140 | COG | COG0463 | Glycosyltransferase involved in cell wall bisynthesis | NA |
| UHGV-1262590_140 | Structural annotation | PF13641, MF_01164, NF007482, COG1215 | NA | NA |
| UHGV-1262590_141 | Structural annotation | PF14282 | NA | NA |
| UHGV-1262590_142 | Pfam | PF03889 | Alternative ribosome-rescue factor A | ArfA |
| UHGV-1262590_147 | UniRef90 | UniRef90_A0A8D9C9R1 | Gp39 | NA |
| UHGV-1262590_150 | PHROG | phrog_18912 | NA | unknown function |
| UHGV-1262590_150 | UniRef90 | UniRef90_A0A517DQL5 | ACP-type MB domain-containing protein | NA |
| UHGV-1262590_150 | eggNOG-mapper | 411467.BACCAP_03130 | NA | NA |
| UHGV-1262590_150 | Structural annotation | PF17981 | NA | NA |
| UHGV-1262590_151 | KOfam | K01258 | pepT; tripeptide aminopeptidase [EC:3.4.11.4] | NA |
| UHGV-1262590_151 | PHROG | phrog_34186 | NA | unknown function |
| UHGV-1262590_151 | UniRef90 | UniRef90_A0A843FCH3 | M28 family peptidase | NA |
| UHGV-1262590_151 | eggNOG-mapper | 935948.KE386495_gene2240 | Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls | NA |
| UHGV-1262590_151 | Pfam | PF04389 | Peptidase family M28 | Peptidase_M28 |
| UHGV-1262590_151 | COG | COG0624 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase | NA |
| UHGV-1262590_151 | Structural annotation | PF05343, MF_01120, TIGR01883, COG1363 | NA | NA |
| UHGV-1262590_152 | Structural annotation | PF02581 | NA | NA |
| UHGV-1262590_153 | Structural annotation | PF05584, MF_01909, TIGR02719, COG5625 | NA | NA |
| UHGV-1262590_155 | PHROG | phrog_2319 | NA | unknown function |
| UHGV-1262590_155 | eggNOG-mapper | 713586.KB900537_gene3115 | NA | NA |
| UHGV-1262590_156 | KOfam | K21993 | fdhC; formate transporter | NA |
| UHGV-1262590_156 | UniRef90 | UniRef90_A0A843FJL3 | Formate/nitrite transporter family protein | NA |
| UHGV-1262590_156 | eggNOG-mapper | 1235802.C823_01919 | Formate/nitrite transporter | NA |
| UHGV-1262590_156 | Pfam | PF01226 | Formate/nitrite transporter | Form_Nir_trans |
| UHGV-1262590_156 | COG | COG2116 | Formate/nitrite transporter FocA, FNT family | NA |
| UHGV-1262590_156 | Structural annotation | PF01226, MF_01146, NF007261, COG2116 | NA | NA |
| UHGV-1262590_157 | eggNOG-mapper | 411467.BACCAP_03130 | NA | NA |
| UHGV-1262590_158 | Structural annotation | MF_00040 | NA | NA |