| UHGV-1375216_1 | KOfam | K00558 | DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] | NA |
| UHGV-1375216_1 | PHROG | phrog_116 | DNA methyltransferase | other |
| UHGV-1375216_1 | UniRef90 | UniRef90_D4JYK0 | DNA (cytosine-5-)-methyltransferase | NA |
| UHGV-1375216_1 | eggNOG-mapper | 718252.FP2_16350 | C-5 cytosine-specific DNA methylase | NA |
| UHGV-1375216_1 | PADLOC | oMTase_00004 | orphan methyltransferase | RM |
| UHGV-1375216_1 | Pfam | PF00145 | C-5 cytosine-specific DNA methylase | DNA_methylase |
| UHGV-1375216_1 | COG | COG0270 | DNA-cytosine methylase | NA |
| UHGV-1375216_2 | KOfam | K03111 | ssb; single-strand DNA-binding protein | NA |
| UHGV-1375216_2 | PHROG | phrog_44 | single strand DNA binding protein | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_2 | UniRef90 | UniRef90_A0A6N7TNV3 | Single-stranded DNA-binding protein | NA |
| UHGV-1375216_2 | eggNOG-mapper | 748224.HMPREF9436_03359 | Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism | NA |
| UHGV-1375216_2 | Pfam | PF00436 | Single-strand binding protein family | SSB |
| UHGV-1375216_2 | NCBIFam | TIGR00621.2 | single-stranded DNA-binding protein | NA |
| UHGV-1375216_2 | COG | COG0629 | Single-stranded DNA-binding protein | NA |
| UHGV-1375216_2 | HAMAP | MF_00984 | Single-stranded DNA-binding protein | NA |
| UHGV-1375216_2 | Structural annotation | PF00436, MF_00984, NF005241, COG0629 | NA | NA |
| UHGV-1375216_3 | PHROG | phrog_155 | Erf-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_3 | UniRef90 | UniRef90_E2ZNS9 | Erf family protein | NA |
| UHGV-1375216_3 | eggNOG-mapper | 748224.HMPREF9436_03360 | ERF superfamily | NA |
| UHGV-1375216_3 | Pfam | PF04404 | ERF superfamily | ERF |
| UHGV-1375216_3 | Structural annotation | PF04404, COG4712 | NA | NA |
| UHGV-1375216_5 | KOfam | K07738 | nrdR; transcriptional repressor NrdR | NA |
| UHGV-1375216_5 | UniRef90 | UniRef90_A0A7Y4S123 | Transcriptional repressor NrdR (Fragment) | NA |
| UHGV-1375216_5 | eggNOG-mapper | 1123401.JHYQ01000003_gene2142 | Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes | NA |
| UHGV-1375216_5 | Pfam | PF01096 | Transcription factor S-II (TFIIS) | TFIIS_C |
| UHGV-1375216_5 | COG | COG1327 | Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains | NA |
| UHGV-1375216_5 | Structural annotation | PF04606, NF007241 | NA | NA |
| UHGV-1375216_6 | Structural annotation | PF14143 | NA | NA |
| UHGV-1375216_8 | eggNOG-mapper | 596152.DesU5LDRAFT_1910 | NA | NA |
| UHGV-1375216_8 | Structural annotation | PF03787, TIGR02581, COG1604 | NA | NA |
| UHGV-1375216_9 | Structural annotation | TIGR03826 | NA | NA |
| UHGV-1375216_11 | PHROG | phrog_63 | anti-repressor Ant | transcription regulation |
| UHGV-1375216_11 | UniRef90 | UniRef90_A0A844D5R9 | Phage regulatory protein/antirepressor Ant | NA |
| UHGV-1375216_11 | eggNOG-mapper | 947981.E9LUT0_9CAUD | DNA binding | NA |
| UHGV-1375216_11 | Pfam | PF09669 | Phage regulatory protein Rha (Phage_pRha) | Phage_pRha |
| UHGV-1375216_11 | Pfam | PF03374 | Phage antirepressor protein KilAC domain | ANT |
| UHGV-1375216_11 | NCBIFam | TIGR02681.1 | phage regulatory protein, Rha family | NA |
| UHGV-1375216_11 | Structural annotation | PF09669, PF03374, TIGR02681, COG3646, COG3645 | NA | NA |
| UHGV-1375216_12 | PHROG | phrog_1468 | transcriptional repressor | transcription regulation |
| UHGV-1375216_12 | UniRef90 | UniRef90_A0A1Y3XM81 | XRE family transcriptional regulator | NA |
| UHGV-1375216_12 | eggNOG-mapper | 428125.CLOLEP_02737 | NA | NA |
| UHGV-1375216_12 | Structural annotation | TIGR03070 | NA | NA |
| UHGV-1375216_13 | PHROG | phrog_8 | transcriptional regulator | transcription regulation |
| UHGV-1375216_13 | UniRef90 | UniRef90_A0A1C6D4U5 | Helix-turn-helix domain | NA |
| UHGV-1375216_13 | eggNOG-mapper | 693746.OBV_43290 | addiction module antidote protein HigA | NA |
| UHGV-1375216_13 | Pfam | PF13443 | Cro/C1-type HTH DNA-binding domain | HTH_26 |
| UHGV-1375216_13 | COG | COG3093 | Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain | NA |
| UHGV-1375216_13 | Structural annotation | PF01381, MF_00535, NF041951, COG3655 | NA | NA |
| UHGV-1375216_17 | UniRef90 | UniRef90_A0A2A7AM70 | HTH cro/C1-type domain-containing protein | NA |
| UHGV-1375216_17 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-1375216_17 | COG | COG1396 | Transcriptional regulator, contains XRE-family HTH domain | NA |
| UHGV-1375216_17 | Structural annotation | PF13560, MF_00535, NF041951, COG1476 | NA | NA |
| UHGV-1375216_18 | PHROG | phrog_4402 | replication initiation protein | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_18 | UniRef90 | UniRef90_A0A0H5Q331 | Rep_3 domain-containing protein | NA |
| UHGV-1375216_18 | eggNOG-mapper | 999413.HMPREF1094_04438 | Initiator Replication protein | NA |
| UHGV-1375216_18 | Pfam | PF01051 | Initiator Replication protein, WH1 | Rep3_N |
| UHGV-1375216_18 | Pfam | PF21205 | Initiator Rep protein, WH2 | Rep3_C |
| UHGV-1375216_18 | COG | COG5527 | Protein involved in initiation of plasmid replication | NA |
| UHGV-1375216_18 | Structural annotation | PF01051, PF21205, NF038290, COG5527 | NA | NA |
| UHGV-1375216_21 | KOfam | K03496 | parA, soj; chromosome partitioning protein | NA |
| UHGV-1375216_21 | PHROG | phrog_164 | ParA-like partition protein | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_21 | UniRef90 | UniRef90_A0A1C6BS15 | Sporulation initiation inhibitor protein soj | NA |
| UHGV-1375216_21 | eggNOG-mapper | 1408423.JHYA01000021_gene392 | Cellulose biosynthesis protein BcsQ | NA |
| UHGV-1375216_21 | Pfam | PF13614 | AAA domain | AAA_31 |
| UHGV-1375216_21 | COG | COG1192 | ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ | NA |
| UHGV-1375216_21 | Structural annotation | PF13614, MF_00533, NF010443, COG1192 | NA | NA |
| UHGV-1375216_23 | Structural annotation | PF07878 | NA | NA |
| UHGV-1375216_24 | PHROG | phrog_10980 | NA | unknown function |
| UHGV-1375216_24 | UniRef90 | UniRef90_G3MA20 | Gp279 | NA |
| UHGV-1375216_25 | KOfam | K13525 | VCP, CDC48; transitional endoplasmic reticulum ATPase | NA |
| UHGV-1375216_25 | PHROG | phrog_3757 | NA | unknown function |
| UHGV-1375216_25 | UniRef90 | UniRef90_A0A4Z0Y6M2 | ATP-dependent zinc metalloprotease FtsH 3 | NA |
| UHGV-1375216_25 | eggNOG-mapper | 768710.DesyoDRAFT_1087 | ATPase family associated with various cellular activities (AAA) | NA |
| UHGV-1375216_25 | PADLOC | IetA_00002 | NA | ietAS |
| UHGV-1375216_25 | Pfam | PF00004 | ATPase family associated with various cellular activities (AAA) | AAA |
| UHGV-1375216_25 | COG | COG0464 | AAA+-type ATPase, SpoVK/Ycf46/Vps4 family | NA |
| UHGV-1375216_25 | Structural annotation | PF00004, MF_00553, TIGR01242, COG1222 | NA | NA |
| UHGV-1375216_26 | Structural annotation | MF_00273 | NA | NA |
| UHGV-1375216_29 | eggNOG-mapper | 1408437.JNJN01000043_gene801 | NA | NA |
| UHGV-1375216_30 | eggNOG-mapper | 1408437.JNJN01000043_gene802 | NA | NA |
| UHGV-1375216_31 | PHROG | phrog_16490 | NA | unknown function |
| UHGV-1375216_31 | eggNOG-mapper | 1408437.JNJN01000043_gene803 | NA | NA |
| UHGV-1375216_35 | KOfam | K22299 | rghR; HTH-type transcriptional regulator, competence development regulator | NA |
| UHGV-1375216_35 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-1375216_35 | Structural annotation | PF01381, TIGR03070, COG1396 | NA | NA |
| UHGV-1375216_37 | PHROG | phrog_15303 | NA | unknown function |
| UHGV-1375216_39 | KOfam | K07273 | acm; lysozyme | NA |
| UHGV-1375216_39 | PHROG | phrog_291 | endolysin | lysis |
| UHGV-1375216_39 | UniRef90 | UniRef90_A0A564U0D3 | Autolytic lysozyme | NA |
| UHGV-1375216_39 | eggNOG-mapper | 718252.FP2_04890 | hydrolase, family 25 | NA |
| UHGV-1375216_39 | Pfam | PF01183 | Glycosyl hydrolases family 25 | Glyco_hydro_25 |
| UHGV-1375216_39 | COG | COG3757 | Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family | NA |
| UHGV-1375216_39 | Structural annotation | PF01183, NF007404, COG3757 | NA | NA |
| UHGV-1375216_40 | PHROG | phrog_28526 | NA | unknown function |
| UHGV-1375216_40 | UniRef90 | UniRef90_A0A2A7AIE2 | Antitoxin | NA |
| UHGV-1375216_40 | eggNOG-mapper | 411462.DORLON_00769 | NA | NA |
| UHGV-1375216_40 | Pfam | PF04255 | NA | DUF433 |
| UHGV-1375216_41 | eggNOG-mapper | 742733.HMPREF9469_05015 | NA | NA |
| UHGV-1375216_42 | UniRef90 | UniRef90_A0A1G6NQ88 | NA | NA |
| UHGV-1375216_42 | eggNOG-mapper | 1321782.HMPREF1986_02279 | COG NOG18825 non supervised orthologous group | NA |
| UHGV-1375216_42 | Structural annotation | PF19789 | NA | NA |
| UHGV-1375216_44 | PHROG | phrog_18725 | NA | unknown function |
| UHGV-1375216_44 | eggNOG-mapper | 718252.FP2_14370 | domain, Protein | NA |
| UHGV-1375216_44 | COG | COG5492 | NA | NA |
| UHGV-1375216_44 | Structural annotation | PF15417, NF041539 | NA | NA |
| UHGV-1375216_45 | PHROG | phrog_13879 | NA | unknown function |
| UHGV-1375216_45 | eggNOG-mapper | 1007103.AFHW01000096_gene3259 | NA | NA |
| UHGV-1375216_45 | Pfam | PF19789 | NA | DUF6273 |
| UHGV-1375216_45 | Structural annotation | PF14594, PF19789, PF03256, PF09134, NF033848, COG3500, COG5156 | NA | NA |
| UHGV-1375216_46 | PHROG | phrog_1194 | NA | unknown function |
| UHGV-1375216_46 | Pfam | PF20458 | NA | DUF6711 |
| UHGV-1375216_46 | Structural annotation | PF20458, TIGR02126, COG3499 | NA | NA |
| UHGV-1375216_47 | PHROG | phrog_1535 | tail length tape measure protein | tail |
| UHGV-1375216_47 | UniRef90 | UniRef90_A0A318EME6 | Phage-related protein | NA |
| UHGV-1375216_47 | eggNOG-mapper | 1121866.AUGK01000003_gene1437 | phage tail tape measure protein | NA |
| UHGV-1375216_47 | COG | COG1280 | Threonine/homoserine/homoserine lactone efflux protein | NA |
| UHGV-1375216_48 | eggNOG-mapper | 1121333.JMLH01000047_gene1011 | NA | NA |
| UHGV-1375216_49 | UniRef90 | UniRef90_UPI00164D364F | NA | NA |
| UHGV-1375216_49 | eggNOG-mapper | 1123263.AUKY01000015_gene1618 | NA | NA |
| UHGV-1375216_49 | Pfam | PF16478 | NA | DUF5055 |
| UHGV-1375216_49 | Structural annotation | PF16478 | NA | NA |
| UHGV-1375216_50 | PHROG | phrog_158 | major tail protein | tail |
| UHGV-1375216_50 | UniRef90 | UniRef90_UPI001D087591 | phage tail protein | NA |
| UHGV-1375216_50 | eggNOG-mapper | 1449343.JQLQ01000002_gene1514 | Phage tail tube protein, TTP | NA |
| UHGV-1375216_50 | Structural annotation | PF16463, TIGR02241, COG5437 | NA | NA |
| UHGV-1375216_51 | Structural annotation | PF06141, TIGR02367, COG3167 | NA | NA |
| UHGV-1375216_52 | eggNOG-mapper | 397290.C810_01411 | NA | NA |
| UHGV-1375216_53 | eggNOG-mapper | 1298920.KI911353_gene2656 | NA | NA |
| UHGV-1375216_53 | Structural annotation | PF19586, TIGR01563, COG5614 | NA | NA |
| UHGV-1375216_54 | UniRef90 | UniRef90_R6N215 | Phage QLRG family putative DNA packaging | NA |
| UHGV-1375216_54 | Structural annotation | TIGR01560 | NA | NA |
| UHGV-1375216_55 | PHROG | phrog_29 | major head protein | head and packaging |
| UHGV-1375216_55 | UniRef90 | UniRef90_A0A2Z4QBB4 | Major capsid protein E | NA |
| UHGV-1375216_55 | eggNOG-mapper | 1347368.HG964404_gene4993 | Phage major capsid protein E | NA |
| UHGV-1375216_55 | Pfam | PF03864 | Phage major capsid protein E | Phage_cap_E |
| UHGV-1375216_55 | Structural annotation | PF03864, MF_04133, NF041162, COG4653 | NA | NA |
| UHGV-1375216_58 | PHROG | phrog_64 | portal protein | head and packaging |
| UHGV-1375216_58 | UniRef90 | UniRef90_A0A371ILT4 | Phage portal protein | NA |
| UHGV-1375216_58 | eggNOG-mapper | 1121866.AUGK01000003_gene1429 | Phage portal protein, SPP1 Gp6-like | NA |
| UHGV-1375216_58 | Pfam | PF05133 | Phage portal protein, SPP1 Gp6-like | Phage_prot_Gp6 |
| UHGV-1375216_58 | Structural annotation | PF05133, MF_04120, TIGR01538, COG5511 | NA | NA |
| UHGV-1375216_60 | PHROG | phrog_38 | terminase large subunit | head and packaging |
| UHGV-1375216_60 | UniRef90 | UniRef90_UPI000419A6BC | phage terminase large subunit | NA |
| UHGV-1375216_60 | eggNOG-mapper | 1121866.AUGK01000003_gene1428 | chromosome segregation | NA |
| UHGV-1375216_60 | COG | COG5410 | NA | NA |
| UHGV-1375216_60 | Structural annotation | PF17289, PF02562, MF_04147, NF033889, COG5362, COG5410 | NA | NA |
| UHGV-1375216_62 | Structural annotation | NF009949 | NA | NA |
| UHGV-1375216_63 | KOfam | K14060 | pinR; putative DNA-invertase from lambdoid prophage Rac | NA |
| UHGV-1375216_63 | PHROG | phrog_125 | DNA invertase | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_63 | UniRef90 | UniRef90_A0A3D0LYX8 | Resolvase | NA |
| UHGV-1375216_63 | eggNOG-mapper | 641107.CDLVIII_3188 | Resolvase, N terminal domain | NA |
| UHGV-1375216_63 | Pfam | PF00239 | Resolvase, N terminal domain | Resolvase |
| UHGV-1375216_63 | COG | COG1961 | Site-specific DNA recombinase SpoIVCA/DNA invertase PinE | NA |
| UHGV-1375216_63 | Structural annotation | PF00239, PF02796, MF_00489, NF009949, COG1961 | NA | NA |
| UHGV-1375216_64 | Structural annotation | PF20075 | NA | NA |
| UHGV-1375216_66 | Structural annotation | PF19807, NF041793, COG4877 | NA | NA |
| UHGV-1375216_67 | KOfam | K07741 | antB; anti-repressor protein | NA |
| UHGV-1375216_67 | PHROG | phrog_130 | anti-repressor Ant | transcription regulation |
| UHGV-1375216_67 | UniRef90 | UniRef90_A0A1Y4EUA0 | Bro-N domain-containing protein | NA |
| UHGV-1375216_67 | eggNOG-mapper | 1289596.M1PKL6_9CAUD | BRO family, N-terminal domain | NA |
| UHGV-1375216_67 | Pfam | PF02498 | BRO family, N-terminal domain | Bro-N |
| UHGV-1375216_67 | Pfam | PF03374 | Phage antirepressor protein KilAC domain | ANT |
| UHGV-1375216_67 | Structural annotation | PF02498, PF03374, TIGR02681, COG3645, COG3561 | NA | NA |
| UHGV-1375216_68 | Structural annotation | PF12869, MF_00720, NF040991, COG4085 | NA | NA |
| UHGV-1375216_72 | COG | COG5377 | Phage-related protein, predicted endonuclease | NA |
| UHGV-1375216_76 | PHROG | phrog_1709 | NA | unknown function |
| UHGV-1375216_76 | eggNOG-mapper | 1280686.AUKE01000002_gene1328 | NA | NA |
| UHGV-1375216_77 | KOfam | K02314 | dnaB; replicative DNA helicase [EC:5.6.2.3] | NA |
| UHGV-1375216_77 | PHROG | phrog_19 | DnaB-like replicative helicase | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_77 | UniRef90 | UniRef90_A0A564SBR1 | Replicative DNA helicase | NA |
| UHGV-1375216_77 | eggNOG-mapper | 1203606.HMPREF1526_01325 | Participates in initiation and elongation during chromosome replication | NA |
| UHGV-1375216_77 | Pfam | PF03796 | DnaB-like helicase C terminal domain | DnaB_C |
| UHGV-1375216_77 | COG | COG0305 | Replicative DNA helicase | NA |
| UHGV-1375216_77 | Structural annotation | PF03796, PF00772, MF_04155, TIGR00665, COG0305 | NA | NA |
| UHGV-1375216_78 | PHROG | phrog_678 | replication initiation O-like | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_78 | Pfam | PF19808 | NA | DUF6291 |
| UHGV-1375216_78 | Structural annotation | PF19808 | NA | NA |
| UHGV-1375216_79 | PHROG | phrog_599 | Lar-like restriction alleviation protein | moron, auxiliary metabolic gene and host takeover |
| UHGV-1375216_79 | Pfam | PF14354 | Restriction alleviation protein Lar | Lar_restr_allev |
| UHGV-1375216_79 | NCBIFam | TIGR03655.1 | Lar family restriction alleviation protein | NA |
| UHGV-1375216_79 | dbAPIS | APIS033 | Lar is functionally similar to RaI, is able to alleviate restriction and enhance modification by EcoKI. And the nucleotide sequences of their genes share 47% identity, indicating a common origin. | NA |
| UHGV-1375216_79 | Structural annotation | PF14354, TIGR03655 | NA | NA |
| UHGV-1375216_80 | Pfam | PF04448 | NA | DUF551 |
| UHGV-1375216_81 | Structural annotation | NF041588 | NA | NA |
| UHGV-1375216_85 | PHROG | phrog_11947 | NA | unknown function |
| UHGV-1375216_88 | UniRef90 | UniRef90_UPI0012DD33A2 | restriction endonuclease subunit M | NA |
| UHGV-1375216_88 | eggNOG-mapper | 1287488.HMPREF0671_07525 | Eco57I restriction-modification methylase | NA |
| UHGV-1375216_88 | PADLOC | MTase_II_00176 | Type II methyltransferase | RM |
| UHGV-1375216_88 | COG | COG0286 | Type I restriction-modification system, DNA methylase subunit | NA |
| UHGV-1375216_89 | Structural annotation | PF16677 | NA | NA |
| UHGV-1375216_90 | PHROG | phrog_7704 | NA | unknown function |
| UHGV-1375216_90 | UniRef90 | UniRef90_UPI001495255A | NA | NA |
| UHGV-1375216_90 | Pfam | PF04448 | NA | DUF551 |
| UHGV-1375216_94 | Structural annotation | PF11998, COG5420 | NA | NA |
| UHGV-1375216_97 | PHROG | phrog_843 | Holliday junction resolvase | DNA, RNA and nucleotide metabolism |
| UHGV-1375216_97 | UniRef90 | UniRef90_UPI001159D907 | Holliday junction resolvase RecU | NA |
| UHGV-1375216_97 | eggNOG-mapper | 929506.CbC4_1203 | Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation | NA |
| UHGV-1375216_97 | Structural annotation | PF03838, MF_00130, NF002581, COG3331 | NA | NA |
| UHGV-1375216_98 | Structural annotation | PF20331, COG5264 | NA | NA |
| UHGV-1375216_100 | PHROG | phrog_16427 | DNA methyltransferase | other |
| UHGV-1375216_100 | UniRef90 | UniRef90_D4KCC8 | DNA (cytosine-5-)-methyltransferase | NA |
| UHGV-1375216_100 | eggNOG-mapper | 718252.FP2_16350 | C-5 cytosine-specific DNA methylase | NA |
| UHGV-1375216_100 | Pfam | PF00145 | C-5 cytosine-specific DNA methylase | DNA_methylase |
| UHGV-1375216_100 | COG | COG0270 | DNA-cytosine methylase | NA |