| UHGV-1376054_1 | PHROG | phrog_4402 | replication initiation protein | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_1 | UniRef90 | UniRef90_A0A0H5Q331 | Rep_3 domain-containing protein | NA |
| UHGV-1376054_1 | eggNOG-mapper | 999413.HMPREF1094_04438 | Initiator Replication protein | NA |
| UHGV-1376054_1 | Pfam | PF01051 | Initiator Replication protein, WH1 | Rep3_N |
| UHGV-1376054_1 | Pfam | PF21205 | Initiator Rep protein, WH2 | Rep3_C |
| UHGV-1376054_1 | COG | COG5527 | Protein involved in initiation of plasmid replication | NA |
| UHGV-1376054_1 | Structural annotation | PF01051, PF21205, NF010305, COG5527 | NA | NA |
| UHGV-1376054_2 | UniRef90 | UniRef90_A0A2A7AM70 | HTH cro/C1-type domain-containing protein | NA |
| UHGV-1376054_2 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-1376054_2 | Structural annotation | PF13560, MF_00535, NF041951, COG1476 | NA | NA |
| UHGV-1376054_5 | Structural annotation | PF16311, NF038219 | NA | NA |
| UHGV-1376054_6 | PHROG | phrog_8 | transcriptional regulator | transcription regulation |
| UHGV-1376054_6 | UniRef90 | UniRef90_A0A1C6D4U5 | Helix-turn-helix domain | NA |
| UHGV-1376054_6 | eggNOG-mapper | 693746.OBV_43290 | addiction module antidote protein HigA | NA |
| UHGV-1376054_6 | Pfam | PF13443 | Cro/C1-type HTH DNA-binding domain | HTH_26 |
| UHGV-1376054_6 | COG | COG3093 | Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain | NA |
| UHGV-1376054_6 | Structural annotation | PF01381, MF_00535, NF041951, COG3655 | NA | NA |
| UHGV-1376054_7 | PHROG | phrog_1468 | transcriptional repressor | transcription regulation |
| UHGV-1376054_7 | UniRef90 | UniRef90_A0A8J6LUU7 | XRE family transcriptional regulator | NA |
| UHGV-1376054_7 | eggNOG-mapper | 428125.CLOLEP_02737 | NA | NA |
| UHGV-1376054_7 | Structural annotation | TIGR03070 | NA | NA |
| UHGV-1376054_8 | PHROG | phrog_4652 | NA | unknown function |
| UHGV-1376054_8 | eggNOG-mapper | 397290.C810_01459 | NA | NA |
| UHGV-1376054_8 | Structural annotation | TIGR02582, COG1604 | NA | NA |
| UHGV-1376054_9 | PHROG | phrog_15946 | NA | unknown function |
| UHGV-1376054_9 | eggNOG-mapper | 1041147.AUFB01000014_gene330 | NA | NA |
| UHGV-1376054_10 | Structural annotation | PF10922 | NA | NA |
| UHGV-1376054_12 | Pfam | PF13443 | Cro/C1-type HTH DNA-binding domain | HTH_26 |
| UHGV-1376054_12 | Structural annotation | PF13443, TIGR02684, COG1476 | NA | NA |
| UHGV-1376054_13 | Structural annotation | PF14143 | NA | NA |
| UHGV-1376054_14 | COG | COG1327 | Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains | NA |
| UHGV-1376054_14 | Structural annotation | PF04606, NF007241 | NA | NA |
| UHGV-1376054_16 | PHROG | phrog_155 | Erf-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_16 | UniRef90 | UniRef90_E2ZNS9 | Erf family protein | NA |
| UHGV-1376054_16 | eggNOG-mapper | 748224.HMPREF9436_03360 | ERF superfamily | NA |
| UHGV-1376054_16 | Pfam | PF04404 | ERF superfamily | ERF |
| UHGV-1376054_16 | Structural annotation | PF04404, COG4712 | NA | NA |
| UHGV-1376054_17 | KOfam | K03111 | ssb; single-strand DNA-binding protein | NA |
| UHGV-1376054_17 | PHROG | phrog_44 | single strand DNA binding protein | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_17 | UniRef90 | UniRef90_A0A6N7TNV3 | Single-stranded DNA-binding protein | NA |
| UHGV-1376054_17 | eggNOG-mapper | 748224.HMPREF9436_03359 | Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism | NA |
| UHGV-1376054_17 | Pfam | PF00436 | Single-strand binding protein family | SSB |
| UHGV-1376054_17 | NCBIFam | TIGR00621.2 | single-stranded DNA-binding protein | NA |
| UHGV-1376054_17 | COG | COG0629 | Single-stranded DNA-binding protein | NA |
| UHGV-1376054_17 | HAMAP | MF_00984 | Single-stranded DNA-binding protein | NA |
| UHGV-1376054_17 | Structural annotation | PF00436, MF_00984, NF005241, COG0629 | NA | NA |
| UHGV-1376054_18 | PHROG | phrog_59 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_18 | UniRef90 | UniRef90_UPI0007D9B0A3 | NUMOD4 motif-containing HNH endonuclease | NA |
| UHGV-1376054_18 | eggNOG-mapper | 945021.TEH_18310 | NUMOD4 motif | NA |
| UHGV-1376054_18 | PADLOC | HEase_00016 | homing endonuclease | RM |
| UHGV-1376054_18 | Pfam | PF07463 | NUMOD4 motif | NUMOD4 |
| UHGV-1376054_18 | Pfam | PF13392 | HNH endonuclease | HNH_3 |
| UHGV-1376054_18 | Structural annotation | PF07463, PF07453, TIGR01453 | NA | NA |
| UHGV-1376054_19 | PHROG | phrog_757 | DNA methyltransferase | other |
| UHGV-1376054_19 | UniRef90 | UniRef90_UPI001C00B13F | DNA cytosine methyltransferase | NA |
| UHGV-1376054_19 | eggNOG-mapper | 748224.HMPREF9436_03069 | DNA (cytosine-5-)-methyltransferase activity | NA |
| UHGV-1376054_19 | COG | COG0270 | DNA-cytosine methylase | NA |
| UHGV-1376054_21 | PHROG | phrog_924 | NA | unknown function |
| UHGV-1376054_21 | Pfam | PF04448 | NA | DUF551 |
| UHGV-1376054_21 | Structural annotation | PF04448 | NA | NA |
| UHGV-1376054_22 | PHROG | phrog_843 | Holliday junction resolvase | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_22 | UniRef90 | UniRef90_UPI001159D907 | Holliday junction resolvase RecU | NA |
| UHGV-1376054_22 | eggNOG-mapper | 929506.CbC4_1203 | Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation | NA |
| UHGV-1376054_22 | Structural annotation | PF03838, MF_00130, NF002581, COG3331 | NA | NA |
| UHGV-1376054_23 | PHROG | phrog_2715 | NA | unknown function |
| UHGV-1376054_23 | eggNOG-mapper | 1158614.I592_01099 | NA | NA |
| UHGV-1376054_23 | Structural annotation | PF18406 | NA | NA |
| UHGV-1376054_27 | KOfam | K00390 | cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] | NA |
| UHGV-1376054_27 | PHROG | phrog_424 | phosphoadenosine phosphosulfate reductase | moron, auxiliary metabolic gene and host takeover |
| UHGV-1376054_27 | UniRef90 | UniRef90_A0A1Y4LU27 | Adenylyl-sulfate reductase | NA |
| UHGV-1376054_27 | eggNOG-mapper | 1408437.JNJN01000032_gene2312 | Phosphoadenosine phosphosulfate reductase | NA |
| UHGV-1376054_27 | PADLOC | BrxP_00001 | BrxP | BREX |
| UHGV-1376054_27 | Pfam | PF01507 | Phosphoadenosine phosphosulfate reductase family | PAPS_reduct |
| UHGV-1376054_27 | COG | COG0175 | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme | NA |
| UHGV-1376054_27 | Structural annotation | PF01507, MF_00064, TIGR02039, COG0175 | NA | NA |
| UHGV-1376054_28 | UniRef90 | UniRef90_UPI0006DCB293 | phosphoadenosine phosphosulfate reductase family protein | NA |
| UHGV-1376054_28 | eggNOG-mapper | 411490.ANACAC_02386 | Phosphoadenosine phosphosulfate reductase | NA |
| UHGV-1376054_28 | COG | COG0175 | 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme | NA |
| UHGV-1376054_31 | Pfam | PF04448 | NA | DUF551 |
| UHGV-1376054_32 | PHROG | phrog_2118 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_32 | UniRef90 | UniRef90_UPI0012DD5A09 | HNH endonuclease | NA |
| UHGV-1376054_32 | eggNOG-mapper | 742740.HMPREF9474_03129 | HNH endonuclease | NA |
| UHGV-1376054_32 | Pfam | PF01844 | HNH endonuclease | HNH |
| UHGV-1376054_32 | COG | COG1403 | 5-methylcytosine-specific restriction endonuclease McrA | NA |
| UHGV-1376054_32 | Structural annotation | TIGR02646, COG1403 | NA | NA |
| UHGV-1376054_33 | Structural annotation | PF16677 | NA | NA |
| UHGV-1376054_34 | UniRef90 | UniRef90_UPI0012DD33A2 | restriction endonuclease subunit M | NA |
| UHGV-1376054_34 | eggNOG-mapper | 596327.PORUE0001_0850 | restriction | NA |
| UHGV-1376054_34 | PADLOC | MTase_II_00176 | Type II methyltransferase | RM |
| UHGV-1376054_34 | COG | COG1002 | Type II restriction/modification system, endonuclease and methylase domains | NA |
| UHGV-1376054_35 | Structural annotation | PF04319, COG4991 | NA | NA |
| UHGV-1376054_41 | Structural annotation | NF041588 | NA | NA |
| UHGV-1376054_42 | Structural annotation | NF041588 | NA | NA |
| UHGV-1376054_45 | Pfam | PF14354 | Restriction alleviation protein Lar | Lar_restr_allev |
| UHGV-1376054_45 | Structural annotation | PF14354 | NA | NA |
| UHGV-1376054_46 | eggNOG-mapper | 1121344.JHZO01000003_gene982 | NA | NA |
| UHGV-1376054_46 | Pfam | PF19808 | NA | DUF6291 |
| UHGV-1376054_47 | PHROG | phrog_678 | replication initiation O-like | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_48 | KOfam | K02314 | dnaB; replicative DNA helicase [EC:5.6.2.3] | NA |
| UHGV-1376054_48 | PHROG | phrog_19 | DnaB-like replicative helicase | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_48 | UniRef90 | UniRef90_A0A564SBR1 | Replicative DNA helicase | NA |
| UHGV-1376054_48 | eggNOG-mapper | 1203606.HMPREF1526_01325 | Participates in initiation and elongation during chromosome replication | NA |
| UHGV-1376054_48 | Pfam | PF03796 | DnaB-like helicase C terminal domain | DnaB_C |
| UHGV-1376054_48 | COG | COG0305 | Replicative DNA helicase | NA |
| UHGV-1376054_48 | Structural annotation | PF03796, PF00772, MF_04155, TIGR00665, COG0305 | NA | NA |
| UHGV-1376054_51 | PHROG | phrog_186 | DnaD-like helicase loader | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_51 | UniRef90 | UniRef90_B0NH38 | Replication initiator protein A domain protein | NA |
| UHGV-1376054_51 | eggNOG-mapper | 411468.CLOSCI_02792 | Replication initiator protein A (RepA) N-terminus | NA |
| UHGV-1376054_51 | Pfam | PF13730 | Helix-turn-helix domain | HTH_36 |
| UHGV-1376054_51 | COG | COG1349 | DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family | NA |
| UHGV-1376054_51 | Structural annotation | PF06970, MF_01177, NF040642, COG5625 | NA | NA |
| UHGV-1376054_53 | PHROG | phrog_434 | RecE-like recombination exonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_53 | eggNOG-mapper | 742738.HMPREF9460_00717 | YqaJ viral recombinase family | NA |
| UHGV-1376054_53 | COG | COG5377 | Phage-related protein, predicted endonuclease | NA |
| UHGV-1376054_58 | Structural annotation | PF09624, PF14263, MF_00791, NF038353, TIGR02588, COG4885 | NA | NA |
| UHGV-1376054_59 | PHROG | phrog_463 | anti-repressor | transcription regulation |
| UHGV-1376054_59 | UniRef90 | UniRef90_UPI001C2426FA | phage antirepressor Ant | NA |
| UHGV-1376054_59 | eggNOG-mapper | 445972.ANACOL_01862 | Phage antirepressor protein KilAC domain | NA |
| UHGV-1376054_59 | Pfam | PF02498 | BRO family, N-terminal domain | Bro-N |
| UHGV-1376054_59 | COG | COG3617 | Prophage antirepressor | NA |
| UHGV-1376054_59 | Structural annotation | PF03374, PF02498, COG3645, COG3617 | NA | NA |
| UHGV-1376054_60 | Pfam | PF01402 | Ribbon-helix-helix protein, copG family | RHH_1 |
| UHGV-1376054_60 | Structural annotation | PF01402, NF041284, COG4710 | NA | NA |
| UHGV-1376054_63 | KOfam | K14060 | pinR; putative DNA-invertase from lambdoid prophage Rac | NA |
| UHGV-1376054_63 | PHROG | phrog_125 | DNA invertase | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_63 | UniRef90 | UniRef90_A0A3D0LYX8 | Resolvase | NA |
| UHGV-1376054_63 | eggNOG-mapper | 1410633.JHWR01000012_gene95 | Resolvase, N terminal domain | NA |
| UHGV-1376054_63 | Pfam | PF00239 | Resolvase, N terminal domain | Resolvase |
| UHGV-1376054_63 | COG | COG1961 | Site-specific DNA recombinase SpoIVCA/DNA invertase PinE | NA |
| UHGV-1376054_63 | Structural annotation | PF00239, PF02796, MF_00489, NF009949, COG1961 | NA | NA |
| UHGV-1376054_66 | PHROG | phrog_38 | terminase large subunit | head and packaging |
| UHGV-1376054_66 | UniRef90 | UniRef90_A0A810QA10 | Terminase | NA |
| UHGV-1376054_66 | eggNOG-mapper | 1298920.KI911353_gene2682 | TIGRFAM Phage | NA |
| UHGV-1376054_66 | COG | COG5410 | NA | NA |
| UHGV-1376054_66 | Structural annotation | PF17289, PF02562, MF_04147, NF033889, COG5362, COG5410 | NA | NA |
| UHGV-1376054_68 | PHROG | phrog_64 | portal protein | head and packaging |
| UHGV-1376054_68 | UniRef90 | UniRef90_A0A371ILT4 | Phage portal protein | NA |
| UHGV-1376054_68 | eggNOG-mapper | 1121866.AUGK01000003_gene1429 | Phage portal protein, SPP1 Gp6-like | NA |
| UHGV-1376054_68 | Pfam | PF05133 | Phage portal protein, SPP1 Gp6-like | Phage_prot_Gp6 |
| UHGV-1376054_68 | Structural annotation | PF05133, MF_04120, TIGR01538, COG5511 | NA | NA |
| UHGV-1376054_71 | PHROG | phrog_29 | major head protein | head and packaging |
| UHGV-1376054_71 | UniRef90 | UniRef90_A0A2Z4QBB4 | Major capsid protein E | NA |
| UHGV-1376054_71 | eggNOG-mapper | 476272.RUMHYD_01946 | Phage major capsid protein E | NA |
| UHGV-1376054_71 | Pfam | PF03864 | Phage major capsid protein E | Phage_cap_E |
| UHGV-1376054_71 | Structural annotation | PF03864, MF_04133, NF041162, COG4653 | NA | NA |
| UHGV-1376054_72 | UniRef90 | UniRef90_R6N215 | Phage QLRG family putative DNA packaging | NA |
| UHGV-1376054_72 | Structural annotation | TIGR01560 | NA | NA |
| UHGV-1376054_73 | eggNOG-mapper | 1298920.KI911353_gene2656 | NA | NA |
| UHGV-1376054_73 | Structural annotation | PF19586, TIGR01563, COG5614 | NA | NA |
| UHGV-1376054_75 | Structural annotation | PF06141, TIGR02367, COG3167 | NA | NA |
| UHGV-1376054_76 | PHROG | phrog_158 | major tail protein | tail |
| UHGV-1376054_76 | UniRef90 | UniRef90_UPI001D087591 | phage tail protein | NA |
| UHGV-1376054_76 | eggNOG-mapper | 1449343.JQLQ01000002_gene1514 | Phage tail tube protein, TTP | NA |
| UHGV-1376054_76 | Structural annotation | PF16463, TIGR02241, COG5437 | NA | NA |
| UHGV-1376054_77 | UniRef90 | UniRef90_A0A847YX95 | NA | NA |
| UHGV-1376054_77 | eggNOG-mapper | 1123263.AUKY01000015_gene1618 | NA | NA |
| UHGV-1376054_77 | Pfam | PF16478 | NA | DUF5055 |
| UHGV-1376054_77 | Structural annotation | PF16478 | NA | NA |
| UHGV-1376054_78 | eggNOG-mapper | 1121333.JMLH01000047_gene1011 | NA | NA |
| UHGV-1376054_79 | PHROG | phrog_1535 | tail length tape measure protein | tail |
| UHGV-1376054_79 | eggNOG-mapper | 1121866.AUGK01000003_gene1437 | phage tail tape measure protein | NA |
| UHGV-1376054_79 | COG | COG1280 | Threonine/homoserine/homoserine lactone efflux protein | NA |
| UHGV-1376054_80 | PHROG | phrog_1194 | NA | unknown function |
| UHGV-1376054_80 | eggNOG-mapper | 665956.HMPREF1032_03629 | NA | NA |
| UHGV-1376054_80 | Pfam | PF20458 | NA | DUF6711 |
| UHGV-1376054_80 | Structural annotation | PF20458, TIGR02126, COG3499 | NA | NA |
| UHGV-1376054_81 | PHROG | phrog_13879 | NA | unknown function |
| UHGV-1376054_81 | UniRef90 | UniRef90_A0A843H6J9 | Dockerin type I repeat-containing protein | NA |
| UHGV-1376054_81 | eggNOG-mapper | 324057.Pjdr2_1554 | NA | NA |
| UHGV-1376054_81 | Structural annotation | PF14594, PF03256, NF033848, COG4379, COG5156 | NA | NA |
| UHGV-1376054_82 | PHROG | phrog_18725 | NA | unknown function |
| UHGV-1376054_82 | eggNOG-mapper | 1226322.HMPREF1545_00062 | NA | NA |
| UHGV-1376054_84 | PHROG | phrog_23587 | NA | unknown function |
| UHGV-1376054_84 | eggNOG-mapper | 748224.HMPREF9436_00405 | domain, Protein | NA |
| UHGV-1376054_84 | COG | COG5492 | NA | NA |
| UHGV-1376054_84 | Structural annotation | MF_04106 | NA | NA |
| UHGV-1376054_85 | PHROG | phrog_9534 | head protein | head and packaging |
| UHGV-1376054_85 | UniRef90 | UniRef90_A0A3A9HSP0 | Tail fiber protein | NA |
| UHGV-1376054_85 | eggNOG-mapper | 748224.HMPREF9436_00405 | domain, Protein | NA |
| UHGV-1376054_85 | COG | COG5492 | NA | NA |
| UHGV-1376054_87 | Structural annotation | NF040910 | NA | NA |
| UHGV-1376054_88 | KOfam | K07273 | acm; lysozyme | NA |
| UHGV-1376054_88 | PHROG | phrog_291 | endolysin | lysis |
| UHGV-1376054_88 | UniRef90 | UniRef90_A0A564U0D3 | Autolytic lysozyme | NA |
| UHGV-1376054_88 | eggNOG-mapper | 718252.FP2_04890 | hydrolase, family 25 | NA |
| UHGV-1376054_88 | Pfam | PF01183 | Glycosyl hydrolases family 25 | Glyco_hydro_25 |
| UHGV-1376054_88 | COG | COG3757 | Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family | NA |
| UHGV-1376054_88 | Structural annotation | PF01183, TIGR04053, COG3757 | NA | NA |
| UHGV-1376054_90 | PHROG | phrog_15303 | NA | unknown function |
| UHGV-1376054_95 | PHROG | phrog_16490 | NA | unknown function |
| UHGV-1376054_95 | eggNOG-mapper | 1408437.JNJN01000043_gene803 | NA | NA |
| UHGV-1376054_96 | eggNOG-mapper | 1408437.JNJN01000043_gene802 | NA | NA |
| UHGV-1376054_97 | eggNOG-mapper | 1408437.JNJN01000043_gene801 | NA | NA |
| UHGV-1376054_99 | Pfam | PF04448 | NA | DUF551 |
| UHGV-1376054_100 | KOfam | K13525 | VCP, CDC48; transitional endoplasmic reticulum ATPase | NA |
| UHGV-1376054_100 | PHROG | phrog_3757 | NA | unknown function |
| UHGV-1376054_100 | UniRef90 | UniRef90_A0A4Z0Y6M2 | ATP-dependent zinc metalloprotease FtsH 3 | NA |
| UHGV-1376054_100 | eggNOG-mapper | 768710.DesyoDRAFT_1087 | ATPase family associated with various cellular activities (AAA) | NA |
| UHGV-1376054_100 | PADLOC | IetA_00002 | NA | ietAS |
| UHGV-1376054_100 | Pfam | PF00004 | ATPase family associated with various cellular activities (AAA) | AAA |
| UHGV-1376054_100 | COG | COG0464 | AAA+-type ATPase, SpoVK/Ycf46/Vps4 family | NA |
| UHGV-1376054_100 | Structural annotation | PF00004, MF_00553, TIGR01242, COG1222 | NA | NA |
| UHGV-1376054_101 | Structural annotation | PF07878 | NA | NA |
| UHGV-1376054_103 | KOfam | K03496 | parA, soj; chromosome partitioning protein | NA |
| UHGV-1376054_103 | PHROG | phrog_164 | ParA-like partition protein | DNA, RNA and nucleotide metabolism |
| UHGV-1376054_103 | UniRef90 | UniRef90_A0A1C6BS15 | Sporulation initiation inhibitor protein soj | NA |
| UHGV-1376054_103 | eggNOG-mapper | 1408423.JHYA01000021_gene392 | Cellulose biosynthesis protein BcsQ | NA |
| UHGV-1376054_103 | Pfam | PF13614 | AAA domain | AAA_31 |
| UHGV-1376054_103 | COG | COG1192 | ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ | NA |
| UHGV-1376054_103 | Structural annotation | PF13614, MF_00533, NF010443, COG1192 | NA | NA |