| UHGV-2127328_1 | PHROG | phrog_36 | transcriptional regulator | transcription regulation |
| UHGV-2127328_1 | UniRef90 | UniRef90_A0A348ZBT0 | RNA_pol_sigma70 domain-containing protein | NA |
| UHGV-2127328_1 | eggNOG-mapper | 742741.HMPREF9475_02386 | sigma factor activity | NA |
| UHGV-2127328_1 | COG | COG1191 | DNA-directed RNA polymerase specialized sigma subunit | NA |
| UHGV-2127328_1 | Structural annotation | PF07374, MF_00674, NF008895, COG1342 | NA | NA |
| UHGV-2127328_2 | PHROG | phrog_10934 | NA | unknown function |
| UHGV-2127328_2 | UniRef90 | UniRef90_Q7Y4M2 | Gp2 | NA |
| UHGV-2127328_2 | eggNOG-mapper | 157924.Q7Y4M2_9CAUD | NA | NA |
| UHGV-2127328_3 | PHROG | phrog_606 | terminase small subunit | head and packaging |
| UHGV-2127328_3 | UniRef90 | UniRef90_A0A1I3PZ25 | DNA-packaging protein gp3 | NA |
| UHGV-2127328_3 | eggNOG-mapper | 536233.CLO_1560 | DNA-packaging protein gp3 | NA |
| UHGV-2127328_3 | Pfam | PF16677 | DNA-packaging protein gp3 | GP3_package |
| UHGV-2127328_4 | KOfam | K06909 | xtmB; phage terminase large subunit | NA |
| UHGV-2127328_4 | PHROG | phrog_3717 | terminase large subunit | head and packaging |
| UHGV-2127328_4 | UniRef90 | UniRef90_UPI00189AA0BC | PBSX family phage terminase large subunit | NA |
| UHGV-2127328_4 | eggNOG-mapper | 1499683.CCFF01000017_gene2580 | Phage terminase, large subunit, PBSX family | NA |
| UHGV-2127328_4 | Pfam | PF04466 | Phage terminase large subunit | Terminase_3 |
| UHGV-2127328_4 | Pfam | PF17288 | Terminase RNAseH like domain | Terminase_3C |
| UHGV-2127328_4 | NCBIFam | TIGR01547.1 | PBSX family phage terminase large subunit | NA |
| UHGV-2127328_4 | COG | COG1783 | Phage terminase large subunit | NA |
| UHGV-2127328_4 | Structural annotation | PF04466, PF17288, MF_04145, TIGR01547, COG1783 | NA | NA |
| UHGV-2127328_5 | PHROG | phrog_64 | portal protein | head and packaging |
| UHGV-2127328_5 | UniRef90 | UniRef90_A0A6N3FG53 | Phage portal protein, SPP1 Gp6-like | NA |
| UHGV-2127328_5 | eggNOG-mapper | 1499683.CCFF01000017_gene2144 | portal protein, SPP1 Gp6-like | NA |
| UHGV-2127328_5 | Pfam | PF05133 | Phage portal protein, SPP1 Gp6-like | Phage_prot_Gp6 |
| UHGV-2127328_5 | Structural annotation | PF05133, MF_04120, TIGR01538, COG5511 | NA | NA |
| UHGV-2127328_6 | PHROG | phrog_115 | minor head protein | head and packaging |
| UHGV-2127328_6 | UniRef90 | UniRef90_UPI0005A64308 | minor capsid protein | NA |
| UHGV-2127328_6 | eggNOG-mapper | 1499683.CCFF01000017_gene2145 | Phage Mu protein F like protein | NA |
| UHGV-2127328_6 | Pfam | PF04233 | Phage Mu protein F like protein | Phage_Mu_F |
| UHGV-2127328_6 | NCBIFam | TIGR01641.1 | minor capsid protein | NA |
| UHGV-2127328_6 | COG | COG2369 | NA | NA |
| UHGV-2127328_6 | Structural annotation | PF04233, TIGR01641, COG2369 | NA | NA |
| UHGV-2127328_7 | PHROG | phrog_172 | head scaffolding protein | head and packaging |
| UHGV-2127328_7 | UniRef90 | UniRef90_UPI00082CC29D | NA | NA |
| UHGV-2127328_7 | eggNOG-mapper | 1499683.CCFF01000017_gene2146 | NA | NA |
| UHGV-2127328_7 | Pfam | PF14265 | NA | DUF4355 |
| UHGV-2127328_7 | Structural annotation | PF14265 | NA | NA |
| UHGV-2127328_8 | PHROG | phrog_267 | major head protein | head and packaging |
| UHGV-2127328_8 | UniRef90 | UniRef90_A0A7V8IA85 | Phage coat protein gp6 | NA |
| UHGV-2127328_8 | eggNOG-mapper | 1321778.HMPREF1982_03550 | P22 coat protein-protein 5 domain protein | NA |
| UHGV-2127328_8 | Structural annotation | PF19821, MF_04119, TIGR04387, COG4653 | NA | NA |
| UHGV-2127328_10 | eggNOG-mapper | 1499683.CCFF01000017_gene2149 | NA | NA |
| UHGV-2127328_10 | Pfam | PF10429 | Nuclear pore RNA shuttling protein Mtr2 | Mtr2 |
| UHGV-2127328_10 | Structural annotation | PF07405, TIGR01563, COG5614 | NA | NA |
| UHGV-2127328_11 | UniRef90 | UniRef90_UPI000C06B6F1 | HK97 gp10 family phage protein | NA |
| UHGV-2127328_11 | Pfam | PF04883 | Bacteriophage HK97-gp10, putative tail-component | HK97-gp10_like |
| UHGV-2127328_11 | Structural annotation | PF04883, TIGR01725 | NA | NA |
| UHGV-2127328_12 | Structural annotation | PF20765 | NA | NA |
| UHGV-2127328_13 | PHROG | phrog_885 | major tail protein | tail |
| UHGV-2127328_13 | Structural annotation | PF06488, TIGR01603, COG5437 | NA | NA |
| UHGV-2127328_14 | PHROG | phrog_1021 | NA | unknown function |
| UHGV-2127328_16 | PHROG | phrog_1272 | tail length tape measure protein | tail |
| UHGV-2127328_16 | UniRef90 | UniRef90_A0A6B0DZQ8 | PhageMin_Tail domain-containing protein | NA |
| UHGV-2127328_16 | eggNOG-mapper | 573061.Clocel_3533 | tail tape measure protein | NA |
| UHGV-2127328_16 | Pfam | PF10145 | Phage-related minor tail protein | PhageMin_Tail |
| UHGV-2127328_16 | NCBIFam | TIGR01760.1 | phage tail tape measure protein | NA |
| UHGV-2127328_16 | COG | COG5280 | Phage-related minor tail protein | NA |
| UHGV-2127328_16 | Structural annotation | PF10145, TIGR01760, COG5280 | NA | NA |
| UHGV-2127328_17 | PHROG | phrog_33 | distal tail protein Dit | tail |
| UHGV-2127328_17 | UniRef90 | UniRef90_A0A1C6KY20 | Phage-related protein | NA |
| UHGV-2127328_17 | eggNOG-mapper | 573061.Clocel_3532 | tail component | NA |
| UHGV-2127328_17 | NCBIFam | TIGR01633.1 | distal tail protein Dit | NA |
| UHGV-2127328_17 | COG | COG4722 | Phage-related protein YomH | NA |
| UHGV-2127328_17 | Structural annotation | PF20195, TIGR01633, COG4722 | NA | NA |
| UHGV-2127328_18 | PHROG | phrog_7043 | tail protein | tail |
| UHGV-2127328_18 | UniRef90 | UniRef90_UPI00164B3F86 | phage tail protein | NA |
| UHGV-2127328_18 | eggNOG-mapper | 573061.Clocel_3531 | Phage minor structural protein | NA |
| UHGV-2127328_18 | Pfam | PF06605 | Prophage endopeptidase tail | Prophage_tail |
| UHGV-2127328_18 | NCBIFam | TIGR01665.1 | phage tail spike protein | NA |
| UHGV-2127328_18 | COG | COG4926 | Phage-related protein | NA |
| UHGV-2127328_19 | PHROG | phrog_7043 | tail protein | tail |
| UHGV-2127328_19 | eggNOG-mapper | 573061.Clocel_3531 | Phage minor structural protein | NA |
| UHGV-2127328_19 | COG | COG4926 | Phage-related protein | NA |
| UHGV-2127328_20 | PHROG | phrog_16573 | NA | unknown function |
| UHGV-2127328_20 | UniRef90 | UniRef90_Q9AZX4 | Orf55 | NA |
| UHGV-2127328_20 | eggNOG-mapper | 1280689.AUJC01000011_gene1533 | NA | NA |
| UHGV-2127328_20 | Pfam | PF10651 | BppU N-terminal domain | BppU_N |
| UHGV-2127328_20 | COG | COG2755 | Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK | NA |
| UHGV-2127328_23 | PHROG | phrog_6782 | tail fiber protein | tail |
| UHGV-2127328_23 | eggNOG-mapper | 1391647.AVSV01000022_gene2575 | NA | NA |
| UHGV-2127328_25 | NCBIFam | NF040910.1 | CD1375 family protein | NA |
| UHGV-2127328_26 | PHROG | phrog_2428 | NA | unknown function |
| UHGV-2127328_26 | UniRef90 | UniRef90_UPI0015714EBB | ABC transporter ATPase | NA |
| UHGV-2127328_26 | eggNOG-mapper | 272562.CA_C1899 | NA | NA |
| UHGV-2127328_26 | dbAPIS | APIS024 | Tad1 proteins are not an enzymes, but are 'sponges' that bind and sequester the immune signaling molecule (cyclic ADP-ribose or gcADPR) produced by TIR-domain proteins, thus decoupling phage sensing from immune effector activation and rendering Thoeris inactive. | NA |
| UHGV-2127328_27 | PHROG | phrog_37799 | NA | unknown function |
| UHGV-2127328_27 | UniRef90 | UniRef90_A0A3P6K437 | Cell wall hydrolase protein | NA |
| UHGV-2127328_27 | eggNOG-mapper | 272563.CD630_06610 | Bacteriophage holin family | NA |
| UHGV-2127328_27 | Pfam | PF05105 | Bacteriophage holin family | Phage_holin_4_1 |
| UHGV-2127328_27 | NCBIFam | TIGR01593.1 | toxin secretion/phage lysis holin | NA |
| UHGV-2127328_27 | COG | COG4824 | Phage-related holin (Lysis protein) | NA |
| UHGV-2127328_27 | Structural annotation | PF05105, TIGR01593, COG4824 | NA | NA |
| UHGV-2127328_28 | KOfam | K07273 | acm; lysozyme | NA |
| UHGV-2127328_28 | PHROG | phrog_6219 | endolysin | lysis |
| UHGV-2127328_28 | UniRef90 | UniRef90_A0A1I7FA26 | Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family | NA |
| UHGV-2127328_28 | eggNOG-mapper | 290402.Cbei_1666 | family 25 | NA |
| UHGV-2127328_28 | Pfam | PF01183 | Glycosyl hydrolases family 25 | Glyco_hydro_25 |
| UHGV-2127328_28 | Pfam | PF01471 | Putative peptidoglycan binding domain | PG_binding_1 |
| UHGV-2127328_28 | COG | COG3757 | Lyzozyme M1 (1,4-beta-N-acetylmuramidase), GH25 family | NA |
| UHGV-2127328_29 | PHROG | phrog_6775 | NA | unknown function |
| UHGV-2127328_29 | AcrCatalog | cluster_37489 | NA | NA |
| UHGV-2127328_30 | PHROG | phrog_2329 | NA | unknown function |
| UHGV-2127328_30 | Pfam | PF04014 | Antidote-toxin recognition MazE, bacterial antitoxin | MazE_antitoxin |
| UHGV-2127328_30 | COG | COG2336 | Antitoxin component MazE of the MazEF toxin-antitoxin module | NA |
| UHGV-2127328_32 | UniRef90 | UniRef90_A0A6B4JHU8 | Helix-turn-helix domain-containing protein | NA |
| UHGV-2127328_32 | eggNOG-mapper | 536233.CLO_0566 | NA | NA |
| UHGV-2127328_32 | Pfam | PF13730 | Helix-turn-helix domain | HTH_36 |
| UHGV-2127328_32 | Structural annotation | PF07106, MF_01177, NF040642, COG0640 | NA | NA |
| UHGV-2127328_33 | Structural annotation | PF13113, NF008362, COG3978 | NA | NA |
| UHGV-2127328_34 | KOfam | K06400 | spoIVCA; site-specific DNA recombinase | NA |
| UHGV-2127328_34 | PHROG | phrog_95 | integrase | integration and excision |
| UHGV-2127328_34 | UniRef90 | UniRef90_UPI000694B40E | recombinase family protein | NA |
| UHGV-2127328_34 | eggNOG-mapper | 1499683.CCFF01000013_gene486 | Resolvase, N terminal domain | NA |
| UHGV-2127328_34 | Pfam | PF00239 | Resolvase, N terminal domain | Resolvase |
| UHGV-2127328_34 | Pfam | PF07508 | Recombinase | Recombinase |
| UHGV-2127328_34 | Pfam | PF13408 | Recombinase zinc beta ribbon domain | Zn_ribbon_recom |
| UHGV-2127328_34 | COG | COG1961 | Site-specific DNA recombinase SpoIVCA/DNA invertase PinE | NA |
| UHGV-2127328_35 | KOfam | K23779 | sutR; XRE family transcriptional regulator, regulator of sulfur utilization | NA |
| UHGV-2127328_35 | PHROG | phrog_2439 | transcriptional regulator | transcription regulation |
| UHGV-2127328_35 | UniRef90 | UniRef90_UPI001ABAE3CD | helix-turn-helix transcriptional regulator | NA |
| UHGV-2127328_35 | PADLOC | retron_type_VI_hth_cluster2_1 | NA | Retron |
| UHGV-2127328_35 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-2127328_35 | COG | COG1813 | Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains | NA |
| UHGV-2127328_35 | Structural annotation | PF01381, NF041951, COG1396 | NA | NA |
| UHGV-2127328_36 | UniRef90 | UniRef90_UPI0013E40444 | helix-turn-helix domain-containing protein | NA |
| UHGV-2127328_36 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-2127328_36 | COG | COG1396 | Transcriptional regulator, contains XRE-family HTH domain | NA |
| UHGV-2127328_36 | Structural annotation | PF12844, NF041951, COG1476 | NA | NA |
| UHGV-2127328_38 | PHROG | phrog_373 | anti-repressor | transcription regulation |
| UHGV-2127328_38 | UniRef90 | UniRef90_UPI0013720A47 | Rha family transcriptional regulator | NA |
| UHGV-2127328_38 | eggNOG-mapper | 632245.CLP_2719 | ORF6C domain | NA |
| UHGV-2127328_38 | Pfam | PF09669 | Phage regulatory protein Rha (Phage_pRha) | Phage_pRha |
| UHGV-2127328_38 | Pfam | PF10552 | ORF6C domain | ORF6C |
| UHGV-2127328_38 | NCBIFam | TIGR02681.1 | phage regulatory protein, Rha family | NA |
| UHGV-2127328_38 | COG | COG3646 | Phage regulatory protein Rha | NA |
| UHGV-2127328_38 | Structural annotation | PF10552, PF09669, TIGR02681, COG3646 | NA | NA |
| UHGV-2127328_48 | PHROG | phrog_4072 | NA | unknown function |
| UHGV-2127328_48 | eggNOG-mapper | 545697.HMPREF0216_02811 | NA | NA |
| UHGV-2127328_51 | KOfam | K03698 | cbf, cbf1; 3'-5' exoribonuclease [EC:3.1.-.-] | NA |
| UHGV-2127328_51 | PHROG | phrog_5889 | NA | unknown function |
| UHGV-2127328_51 | UniRef90 | UniRef90_A0A7X9XQL6 | HD domain-containing protein | NA |
| UHGV-2127328_51 | eggNOG-mapper | 272562.CA_C1938 | PFAM HD domain | NA |
| UHGV-2127328_51 | Pfam | PF01966 | HD domain | HD |
| UHGV-2127328_51 | COG | COG3481 | 3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation, HD superfamily | NA |
| UHGV-2127328_51 | Structural annotation | PF07514, MF_01427, NF010007, COG3481 | NA | NA |
| UHGV-2127328_52 | PHROG | phrog_2872 | Sak4-like ssDNA annealing protein | DNA, RNA and nucleotide metabolism |
| UHGV-2127328_52 | UniRef90 | UniRef90_UPI0013D1CBB8 | AAA family ATPase | NA |
| UHGV-2127328_52 | eggNOG-mapper | 1415774.U728_1119 | AAA domain | NA |
| UHGV-2127328_52 | Structural annotation | PF13479, MF_00350, TIGR01618, COG0468 | NA | NA |
| UHGV-2127328_53 | PHROG | phrog_18107 | NA | unknown function |
| UHGV-2127328_53 | eggNOG-mapper | 1415774.U728_1116 | NA | NA |
| UHGV-2127328_53 | Pfam | PF05037 | NA | DUF669 |
| UHGV-2127328_53 | Structural annotation | PF05037 | NA | NA |
| UHGV-2127328_54 | KOfam | K00558 | DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] | NA |
| UHGV-2127328_54 | PHROG | phrog_116 | DNA methyltransferase | other |
| UHGV-2127328_54 | UniRef90 | UniRef90_UPI00058F1EB6 | DNA cytosine methyltransferase | NA |
| UHGV-2127328_54 | eggNOG-mapper | 1499683.CCFF01000005_gene54 | PFAM C-5 cytosine-specific DNA methylase | NA |
| UHGV-2127328_54 | PADLOC | MTase_II_00058 | Type II methyltransferase | RM |
| UHGV-2127328_54 | Pfam | PF00145 | C-5 cytosine-specific DNA methylase | DNA_methylase |
| UHGV-2127328_54 | NCBIFam | TIGR00675.1 | DNA (cytosine-5-)-methyltransferase | NA |
| UHGV-2127328_54 | COG | COG0270 | DNA-cytosine methylase | NA |
| UHGV-2127328_54 | Structural annotation | PF00145, TIGR00675, COG0270 | NA | NA |
| UHGV-2127328_57 | PHROG | phrog_3490 | ERCC4-type nuclease | DNA, RNA and nucleotide metabolism |
| UHGV-2127328_57 | UniRef90 | UniRef90_UPI001D58FE1B | ERCC4 domain-containing protein | NA |
| UHGV-2127328_57 | eggNOG-mapper | 536233.CLO_1547 | ERCC4 domain | NA |
| UHGV-2127328_57 | Pfam | PF02732 | ERCC4 domain | ERCC4 |
| UHGV-2127328_57 | Structural annotation | PF02732, NF040956, COG1948 | NA | NA |
| UHGV-2127328_58 | UniRef90 | UniRef90_UPI0012B81C84 | NA | NA |
| UHGV-2127328_58 | eggNOG-mapper | 931276.Cspa_c26710 | NA | NA |
| UHGV-2127328_58 | Pfam | PF18892 | NA | DUF5651 |
| UHGV-2127328_58 | Structural annotation | PF18892 | NA | NA |
| UHGV-2127328_60 | KOfam | K02316 | dnaG; DNA primase [EC:2.7.7.101] | NA |
| UHGV-2127328_60 | PHROG | phrog_26824 | NA | unknown function |
| UHGV-2127328_60 | UniRef90 | UniRef90_UPI0012B914B4 | CHC2 zinc finger domain-containing protein | NA |
| UHGV-2127328_60 | eggNOG-mapper | 318464.IO99_17950 | DNA primase | NA |
| UHGV-2127328_60 | PADLOC | drt-cluster192 | DRT | DRT |
| UHGV-2127328_60 | Pfam | PF01807 | CHC2 zinc finger | zf-CHC2 |
| UHGV-2127328_60 | Pfam | PF05272 | Virulence-associated protein E-like domain | VapE-like_dom |
| UHGV-2127328_60 | COG | COG0358 | DNA primase (bacterial type) | NA |
| UHGV-2127328_60 | Structural annotation | PF08706, PF05272, PF19898, MF_00974, MF_00016, NF005477, COG3378 | NA | NA |