| UHGV-0046876_1 | PHROG | phrog_99 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_1 | UniRef90 | UniRef90_F3AAN4 | AP2/ERF domain-containing protein | NA |
| UHGV-0046876_1 | eggNOG-mapper | 1437363.A0A090C6M5_9CAUD | HNH endonuclease | NA |
| UHGV-0046876_1 | Pfam | PF00847 | AP2 domain | AP2 |
| UHGV-0046876_1 | Structural annotation | PF00847, MF_01580, NF007510 | NA | NA |
| UHGV-0046876_2 | Structural annotation | PF20795 | NA | NA |
| UHGV-0046876_3 | PHROG | phrog_582 | Arc-like repressor | transcription regulation |
| UHGV-0046876_3 | UniRef90 | UniRef90_UPI00129DE9D4 | Arc family DNA-binding protein | NA |
| UHGV-0046876_3 | eggNOG-mapper | 1160721.RBI_I00482 | NA | NA |
| UHGV-0046876_3 | Structural annotation | PF03869, NF010256 | NA | NA |
| UHGV-0046876_5 | KOfam | K01446 | PGRP; peptidoglycan recognition protein | NA |
| UHGV-0046876_5 | PHROG | phrog_7854 | endolysin | lysis |
| UHGV-0046876_5 | UniRef90 | UniRef90_UPI001C3B2E98 | N-acetylmuramoyl-L-alanine amidase | NA |
| UHGV-0046876_5 | eggNOG-mapper | 1235798.C817_04599 | Ami_2 | NA |
| UHGV-0046876_5 | Pfam | PF01510 | N-acetylmuramoyl-L-alanine amidase | Amidase_2 |
| UHGV-0046876_5 | Pfam | PF01473 | Putative cell wall binding repeat | Choline_bind_1 |
| UHGV-0046876_5 | COG | COG3409 | Peptidoglycan-binding (PGRP) domain of peptidoglycan hydrolases | NA |
| UHGV-0046876_6 | PHROG | phrog_1048 | NA | unknown function |
| UHGV-0046876_6 | UniRef90 | UniRef90_UPI001D055B23 | NA | NA |
| UHGV-0046876_6 | eggNOG-mapper | 411462.DORLON_00765 | NA | NA |
| UHGV-0046876_6 | Pfam | PF11195 | NA | DUF2829 |
| UHGV-0046876_6 | dbAPIS | APIS029 | Tad2 is a "sponge" that sequesters the immune signaling molecules produced by Thoeris TIR-domain proteins in response to phage. | NA |
| UHGV-0046876_6 | Structural annotation | PF11195 | NA | NA |
| UHGV-0046876_7 | PHROG | phrog_443 | holin | lysis |
| UHGV-0046876_7 | UniRef90 | UniRef90_UPI001C0212A6 | holin | NA |
| UHGV-0046876_7 | eggNOG-mapper | 1235802.C823_05612 | Putative lactococcus lactis phage r1t holin | NA |
| UHGV-0046876_7 | Pfam | PF16945 | Putative lactococcus lactis phage r1t holin | Phage_r1t_holin |
| UHGV-0046876_7 | Structural annotation | PF16945 | NA | NA |
| UHGV-0046876_9 | PHROG | phrog_2310 | NA | unknown function |
| UHGV-0046876_9 | eggNOG-mapper | 931276.Cspa_c27110 | NA | NA |
| UHGV-0046876_10 | PHROG | phrog_16164 | NA | unknown function |
| UHGV-0046876_10 | eggNOG-mapper | 411470.RUMGNA_00122 | NA | NA |
| UHGV-0046876_10 | Structural annotation | PF10651, NF032891 | NA | NA |
| UHGV-0046876_11 | eggNOG-mapper | 411462.DORLON_00771 | NA | NA |
| UHGV-0046876_12 | PHROG | phrog_25635 | NA | unknown function |
| UHGV-0046876_12 | UniRef90 | UniRef90_A0A173RZM4 | Phage-related holin (Lysis protein) | NA |
| UHGV-0046876_12 | eggNOG-mapper | 411468.CLOSCI_02412 | NA | NA |
| UHGV-0046876_12 | Structural annotation | PF20747 | NA | NA |
| UHGV-0046876_13 | PHROG | phrog_538 | minor tail protein | tail |
| UHGV-0046876_13 | UniRef90 | UniRef90_UPI001E2C8064 | siphovirus ReqiPepy6 Gp37-like family protein | NA |
| UHGV-0046876_13 | eggNOG-mapper | 658655.HMPREF0988_02550 | NA | NA |
| UHGV-0046876_13 | Structural annotation | PF14594, TIGR01665, COG4379 | NA | NA |
| UHGV-0046876_14 | PHROG | phrog_33 | distal tail protein Dit | tail |
| UHGV-0046876_14 | UniRef90 | UniRef90_UPI00156E3DDD | phage tail protein | NA |
| UHGV-0046876_14 | eggNOG-mapper | 665950.HMPREF1025_02521 | NA | NA |
| UHGV-0046876_14 | Structural annotation | PF16774, TIGR01633, COG4722 | NA | NA |
| UHGV-0046876_15 | PHROG | phrog_1533 | tail length tape measure protein | tail |
| UHGV-0046876_15 | UniRef90 | UniRef90_F3AAP8 | PhageMin_Tail domain-containing protein | NA |
| UHGV-0046876_15 | eggNOG-mapper | 903814.ELI_1307 | Phage-related minor tail protein | NA |
| UHGV-0046876_15 | Pfam | PF10145 | Phage-related minor tail protein | PhageMin_Tail |
| UHGV-0046876_15 | NCBIFam | TIGR01760.1 | phage tail tape measure protein | NA |
| UHGV-0046876_15 | COG | COG0739 | Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain | NA |
| UHGV-0046876_15 | Structural annotation | PF10145, MF_04138, TIGR01760, COG5280 | NA | NA |
| UHGV-0046876_16 | PHROG | phrog_709 | NA | unknown function |
| UHGV-0046876_16 | eggNOG-mapper | 879305.HMPREF9290_0132 | NA | NA |
| UHGV-0046876_16 | Structural annotation | PF11836 | NA | NA |
| UHGV-0046876_17 | PHROG | phrog_88 | major tail protein | tail |
| UHGV-0046876_17 | UniRef90 | UniRef90_A0A2V2DCA5 | Phage tail protein | NA |
| UHGV-0046876_17 | eggNOG-mapper | 411471.SUBVAR_05857 | phage major tail protein, phi13 family | NA |
| UHGV-0046876_17 | NCBIFam | TIGR01603.1 | major tail protein | NA |
| UHGV-0046876_17 | Structural annotation | PF06488, TIGR01603 | NA | NA |
| UHGV-0046876_18 | PHROG | phrog_78 | tail terminator | connector |
| UHGV-0046876_18 | eggNOG-mapper | 658655.HMPREF0988_00538 | NA | NA |
| UHGV-0046876_18 | Structural annotation | PF05657, MF_00281, COG0016 | NA | NA |
| UHGV-0046876_19 | PHROG | phrog_5 | tail completion or Neck1 protein | connector |
| UHGV-0046876_19 | UniRef90 | UniRef90_UPI0015710B2F | HK97 gp10 family phage protein | NA |
| UHGV-0046876_19 | eggNOG-mapper | 1304866.K413DRAFT_1229 | NA | NA |
| UHGV-0046876_19 | Pfam | PF04883 | Bacteriophage HK97-gp10, putative tail-component | HK97-gp10_like |
| UHGV-0046876_19 | Structural annotation | PF20039, TIGR01725, COG5005 | NA | NA |
| UHGV-0046876_20 | PHROG | phrog_25 | head closure Hc1 | connector |
| UHGV-0046876_20 | UniRef90 | UniRef90_F3AAQ3 | Phage head-tail adaptor | NA |
| UHGV-0046876_20 | eggNOG-mapper | 1304866.K413DRAFT_1228 | head-tail adaptor | NA |
| UHGV-0046876_20 | Pfam | PF05521 | Phage head-tail joining protein | Phage_H_T_join |
| UHGV-0046876_20 | NCBIFam | TIGR01563.1 | phage head closure protein | NA |
| UHGV-0046876_20 | COG | COG5614 | Phage head-tail adaptor | NA |
| UHGV-0046876_20 | Structural annotation | PF05521, TIGR01563, COG5614 | NA | NA |
| UHGV-0046876_21 | PHROG | phrog_40 | head-tail adaptor Ad1 | connector |
| UHGV-0046876_21 | UniRef90 | UniRef90_A0A2V2DBC2 | Phage gp6-like head-tail connector protein | NA |
| UHGV-0046876_21 | eggNOG-mapper | 1304866.K413DRAFT_1227 | Phage gp6-like head-tail connector protein | NA |
| UHGV-0046876_21 | NCBIFam | TIGR01560.2 | head-tail connector protein | NA |
| UHGV-0046876_21 | Structural annotation | PF05135, TIGR01560 | NA | NA |
| UHGV-0046876_22 | PHROG | phrog_6865 | NA | unknown function |
| UHGV-0046876_22 | Structural annotation | PF01281 | NA | NA |
| UHGV-0046876_23 | PHROG | phrog_10 | major head protein | head and packaging |
| UHGV-0046876_23 | UniRef90 | UniRef90_F3AAQ6 | HK97 family phage major capsid protein | NA |
| UHGV-0046876_23 | eggNOG-mapper | 1414720.CBYM010000002_gene572 | Phage major capsid protein, HK97 family | NA |
| UHGV-0046876_23 | Pfam | PF05065 | Phage capsid family | Phage_capsid |
| UHGV-0046876_23 | NCBIFam | TIGR01554.2 | phage major capsid protein | NA |
| UHGV-0046876_23 | COG | COG4653 | Predicted phage phi-C31 gp36 major capsid-like protein | NA |
| UHGV-0046876_23 | Structural annotation | PF05065, MF_04119, TIGR01554, COG4653 | NA | NA |
| UHGV-0046876_24 | KOfam | K06904 | NA | NA |
| UHGV-0046876_24 | PHROG | phrog_80 | head maturation protease | head and packaging |
| UHGV-0046876_24 | UniRef90 | UniRef90_UPI0009F962E8 | HK97 family phage prohead protease | NA |
| UHGV-0046876_24 | eggNOG-mapper | 397288.C806_00074 | Phage prohead protease, HK97 family | NA |
| UHGV-0046876_24 | Pfam | PF04586 | Caudovirus prohead serine protease | Peptidase_S78 |
| UHGV-0046876_24 | COG | COG3740 | Phage head maturation protease | NA |
| UHGV-0046876_25 | PHROG | phrog_12 | portal protein | head and packaging |
| UHGV-0046876_25 | UniRef90 | UniRef90_A0A8E3N3P1 | Phage portal protein | NA |
| UHGV-0046876_25 | eggNOG-mapper | 508419.F8J160_9CAUD | Phage portal protein | NA |
| UHGV-0046876_25 | Pfam | PF04860 | Phage portal protein | Phage_portal |
| UHGV-0046876_25 | NCBIFam | TIGR01537.1 | phage portal protein | NA |
| UHGV-0046876_25 | Structural annotation | PF04860, MF_04120, TIGR01537, COG4695 | NA | NA |
| UHGV-0046876_26 | PHROG | phrog_9 | terminase large subunit | head and packaging |
| UHGV-0046876_26 | UniRef90 | UniRef90_F3AAQ9 | Phage terminase | NA |
| UHGV-0046876_26 | eggNOG-mapper | 1414720.CBYM010000002_gene575 | Terminase | NA |
| UHGV-0046876_26 | Pfam | PF03354 | Terminase large subunit, ATPase domain | TerL_ATPase |
| UHGV-0046876_26 | Pfam | PF20441 | Terminase large subunit, endonuclease domain | TerL_nuclease |
| UHGV-0046876_26 | COG | COG4626 | Phage terminase-like protein, large subunit, contains N-terminal HTH domain | NA |
| UHGV-0046876_26 | Structural annotation | PF20441, PF03354, MF_04146, TIGR01547, COG4626 | NA | NA |
| UHGV-0046876_27 | UniRef90 | UniRef90_A0A1C6JNN5 | Phage terminase, small subunit | NA |
| UHGV-0046876_27 | eggNOG-mapper | 397288.C806_00077 | NA | NA |
| UHGV-0046876_27 | Structural annotation | PF05119, TIGR01558, COG3747 | NA | NA |
| UHGV-0046876_28 | KOfam | K07451 | mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] | NA |
| UHGV-0046876_28 | PHROG | phrog_144 | HNH endonuclease | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_28 | UniRef90 | UniRef90_F3AAR1 | HNHc domain-containing protein | NA |
| UHGV-0046876_28 | eggNOG-mapper | 397288.C806_00078 | HNH nucleases | NA |
| UHGV-0046876_28 | Pfam | PF01844 | HNH endonuclease | HNH |
| UHGV-0046876_29 | PHROG | phrog_21498 | NA | unknown function |
| UHGV-0046876_29 | UniRef90 | UniRef90_F0NXT0 | ParB-like nuclease | NA |
| UHGV-0046876_29 | eggNOG-mapper | 78346.BRUM_0376 | DNA binding | NA |
| UHGV-0046876_29 | COG | COG1475 | Chromosome segregation protein Spo0J, contains ParB-like nuclease domain | NA |
| UHGV-0046876_29 | Structural annotation | PF05869, TIGR01712 | NA | NA |
| UHGV-0046876_30 | PHROG | phrog_11237 | NA | unknown function |
| UHGV-0046876_30 | eggNOG-mapper | 610130.Closa_0738 | NA | NA |
| UHGV-0046876_31 | PHROG | phrog_6568 | NA | unknown function |
| UHGV-0046876_33 | PHROG | phrog_15198 | NA | unknown function |
| UHGV-0046876_33 | UniRef90 | UniRef90_F3AAR6 | NA | NA |
| UHGV-0046876_33 | Pfam | PF04448 | NA | DUF551 |
| UHGV-0046876_35 | PHROG | phrog_8684 | NA | unknown function |
| UHGV-0046876_35 | UniRef90 | UniRef90_F3AAR8 | YopX domain-containing protein | NA |
| UHGV-0046876_35 | eggNOG-mapper | 742723.HMPREF9477_00921 | YopX protein | NA |
| UHGV-0046876_35 | Pfam | PF09643 | YopX protein | YopX |
| UHGV-0046876_35 | NCBIFam | TIGR01671.1 | phage conserved hypothetical protein TIGR01671 | NA |
| UHGV-0046876_35 | Structural annotation | PF09643, TIGR01671 | NA | NA |
| UHGV-0046876_37 | PHROG | phrog_37410 | NA | unknown function |
| UHGV-0046876_37 | Structural annotation | PF08169, NF037951, COG1918 | NA | NA |
| UHGV-0046876_38 | KOfam | K00558 | DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] | NA |
| UHGV-0046876_38 | PHROG | phrog_116 | DNA methyltransferase | other |
| UHGV-0046876_38 | UniRef90 | UniRef90_F3AAS1 | DNA (cytosine-5-)-methyltransferase | NA |
| UHGV-0046876_38 | eggNOG-mapper | 1123311.KB904448_gene48 | Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family | NA |
| UHGV-0046876_38 | PADLOC | MTase_II_00058 | Type II methyltransferase | RM |
| UHGV-0046876_38 | Pfam | PF00145 | C-5 cytosine-specific DNA methylase | DNA_methylase |
| UHGV-0046876_38 | NCBIFam | TIGR00675.1 | DNA (cytosine-5-)-methyltransferase | NA |
| UHGV-0046876_38 | COG | COG0270 | DNA-cytosine methylase | NA |
| UHGV-0046876_38 | Structural annotation | PF00145, MF_00351, TIGR00675, COG0270 | NA | NA |
| UHGV-0046876_40 | KOfam | K03111 | ssb; single-strand DNA-binding protein | NA |
| UHGV-0046876_40 | PHROG | phrog_44 | single strand DNA binding protein | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_40 | UniRef90 | UniRef90_F3AAS3 | Single-stranded DNA-binding protein | NA |
| UHGV-0046876_40 | eggNOG-mapper | 537007.BLAHAN_04317 | NA | NA |
| UHGV-0046876_40 | Pfam | PF00436 | Single-strand binding protein family | SSB |
| UHGV-0046876_40 | NCBIFam | TIGR00621.2 | single-stranded DNA-binding protein | NA |
| UHGV-0046876_40 | COG | COG0629 | Single-stranded DNA-binding protein | NA |
| UHGV-0046876_40 | HAMAP | MF_00984 | Single-stranded DNA-binding protein | NA |
| UHGV-0046876_40 | Structural annotation | PF00436, MF_00984, NF005580, COG0629 | NA | NA |
| UHGV-0046876_41 | PHROG | phrog_7566 | NA | unknown function |
| UHGV-0046876_41 | eggNOG-mapper | 97139.C824_00037 | NA | NA |
| UHGV-0046876_42 | PHROG | phrog_531 | Rnase H | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_42 | UniRef90 | UniRef90_F3AAS5 | RNase H type-1 domain-containing protein | NA |
| UHGV-0046876_42 | eggNOG-mapper | 990073.ATHU01000002_gene4 | Endonuclease that specifically degrades the RNA of RNA- DNA hybrids | NA |
| UHGV-0046876_42 | Pfam | PF00075 | RNase H | RNase_H |
| UHGV-0046876_42 | COG | COG0328 | Ribonuclease HI | NA |
| UHGV-0046876_42 | Structural annotation | PF00075, MF_00042, NF001236, COG0328 | NA | NA |
| UHGV-0046876_43 | PHROG | phrog_3584 | replication initiation protein | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_43 | eggNOG-mapper | 1232452.BAIB02000007_gene1647 | NA | NA |
| UHGV-0046876_43 | Structural annotation | PF21578 | NA | NA |
| UHGV-0046876_45 | PHROG | phrog_30860 | NA | unknown function |
| UHGV-0046876_50 | KOfam | K18830 | pezA; HTH-type transcriptional regulator / antitoxin PezA | NA |
| UHGV-0046876_50 | PHROG | phrog_8 | transcriptional regulator | transcription regulation |
| UHGV-0046876_50 | UniRef90 | UniRef90_F3AAT3 | HTH cro/C1-type domain-containing protein | NA |
| UHGV-0046876_50 | eggNOG-mapper | 1235798.C817_05486 | Helix-turn-helix XRE-family like proteins | NA |
| UHGV-0046876_50 | Pfam | PF01381 | Helix-turn-helix | HTH_3 |
| UHGV-0046876_50 | COG | COG1396 | Transcriptional regulator, contains XRE-family HTH domain | NA |
| UHGV-0046876_50 | Structural annotation | PF01381, MF_00535, NF041951, COG1476 | NA | NA |
| UHGV-0046876_52 | KOfam | K03088 | rpoE; RNA polymerase sigma-70 factor, ECF subfamily | NA |
| UHGV-0046876_52 | PHROG | phrog_1740 | RNA polymerase sigma factor | transcription regulation |
| UHGV-0046876_52 | UniRef90 | UniRef90_UPI001AE6EB03 | RNA polymerase sigma factor | NA |
| UHGV-0046876_52 | eggNOG-mapper | 1227349.C170_20895 | ECF sigma factor | NA |
| UHGV-0046876_52 | Pfam | PF04542 | Sigma-70 region 2 | Sigma70_r2 |
| UHGV-0046876_52 | Pfam | PF08281 | Sigma-70, region 4 | Sigma70_r4_2 |
| UHGV-0046876_52 | NCBIFam | TIGR02937.1 | sigma-70 family RNA polymerase sigma factor | NA |
| UHGV-0046876_52 | COG | COG1595 | DNA-directed RNA polymerase specialized sigma subunit, sigma24 family | NA |
| UHGV-0046876_53 | KOfam | K02342 | dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] | NA |
| UHGV-0046876_53 | PHROG | phrog_192 | DNA polymerase exonuclease subunit | DNA, RNA and nucleotide metabolism |
| UHGV-0046876_53 | UniRef90 | UniRef90_F3AAT6 | BRCT domain-containing protein | NA |
| UHGV-0046876_53 | eggNOG-mapper | 411467.BACCAP_01159 | EXOIII | NA |
| UHGV-0046876_53 | PADLOC | cd06127 | CAS-I,CAS-II,CAS-III,CAS-IV,CAS-V,CAS-VI; associated | CRISPR-CAS |
| UHGV-0046876_53 | Pfam | PF00929 | Exonuclease | RNase_T |
| UHGV-0046876_53 | Pfam | PF00533 | BRCA1 C Terminus (BRCT) domain | BRCT |
| UHGV-0046876_53 | COG | COG0847 | DNA polymerase III, epsilon subunit or related 3'-5' exonuclease | NA |
| UHGV-0046876_54 | KOfam | K06400 | spoIVCA; site-specific DNA recombinase | NA |
| UHGV-0046876_54 | PHROG | phrog_95 | integrase | integration and excision |
| UHGV-0046876_54 | UniRef90 | UniRef90_A0A1Y3SLY0 | Recombinase family protein | NA |
| UHGV-0046876_54 | eggNOG-mapper | 411460.RUMTOR_02053 | COG COG1961 Site-specific recombinases, DNA invertase Pin homologs | NA |
| UHGV-0046876_54 | Pfam | PF00239 | Resolvase, N terminal domain | Resolvase |
| UHGV-0046876_54 | Pfam | PF07508 | Recombinase | Recombinase |
| UHGV-0046876_54 | Pfam | PF13408 | Recombinase zinc beta ribbon domain | Zn_ribbon_recom |
| UHGV-0046876_54 | COG | COG1961 | Site-specific DNA recombinase SpoIVCA/DNA invertase PinE | NA |
| UHGV-0046876_54 | Structural annotation | PF00239, PF07508, PF13408, NF041201, COG1961 | NA | NA |